ATP2B4 and RASSF1

Number of citations of the paper that reports this interaction (PubMedID 15145946)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		ATP2B4	RASSF1
Description		ATPase plasma membrane Ca2+ transporting 4	Ras association domain family member 1
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GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Caveola Cilium Membrane Basolateral Plasma Membrane Z Disc T-tubule Motile Cilium Protein-containing Complex Ciliary Basal Body Sperm Flagellum Sarcolemma Cell Projection Intracellular Membrane-bounded Organelle Membrane Raft Presynaptic Active Zone Membrane Sperm Principal Piece Glutamatergic Synapse	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Microtubule Cytoskeleton
	Molecular Function	Nucleotide Binding P-type Calcium Transporter Activity Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity ATP Hydrolysis Activity Sodium Channel Regulator Activity Protein Kinase Binding PDZ Domain Binding Protein Phosphatase 2B Binding Nitric-oxide Synthase Inhibitor Activity Metal Ion Binding Nitric-oxide Synthase Binding Scaffold Protein Binding	Protein Binding Zinc Ion Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Neural Retina Development Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Spermatogenesis Negative Regulation Of Gene Expression Urinary Bladder Smooth Muscle Contraction Negative Regulation Of Angiogenesis Hippocampus Development Flagellated Sperm Motility Monoatomic Ion Transmembrane Transport Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cytosolic Calcium Ion Concentration Response To Hydrostatic Pressure Calcium Ion Transmembrane Transport Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Epinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane Negative Regulation Of The Force Of Heart Contraction Transport Across Blood-brain Barrier Negative Regulation Of Arginine Catabolic Process Calcium Ion Export Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Citrulline Biosynthetic Process Regulation Of Cardiac Conduction Cellular Response To Acetylcholine	DNA Damage Response Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Protein Ubiquitination Protein Stabilization Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition
Pathways		Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs		Ritodrine Halothane Desflurane Sevoflurane
Diseases			Nasopharyngeal cancer Non-small cell lung cancer Bladder cancer
GWAS		Appendicular lean mass ( 33097823) Breast size ( 22747683) Composite immunoglobulin trait (IgA x IgG/IgM) ( 28628107) Glycated hemoglobin levels ( 34059833) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immature fraction of reticulocytes ( 32888494) Lymphocyte count ( 32888494 27863252) Malaria ( 22895189 31844061) Mean corpuscular hemoglobin concentration ( 23263863 27863252 32888494 28453575) Mean corpuscular volume ( 27863252 32888494) Monocyte count ( 32888494) Obstructive sleep apnea (average oxygen saturation during sleep) ( 26977737) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)	Basophil percentage of white cells ( 32888494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) High light scatter reticulocyte count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 28991256 30285260) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: CASK CD22 DLG1 DLG2 DLG3 DLG4 ERBIN NOS1 PPP3CA RASSF1 SRC	68 interacting genes: AKT1 ARAF ATM ATP2B4 ATR ATRX AURKA AURKB BRAF C7orf25 C8orf33 CCND2 CCNE1 CDC20 CDK4 CDK6 CDKN2A CDKN2B CLNK CNKSR1 DAXX DDB1 E4F1 EPHA2 ERBB2 EXOSC8 FGFR4 FZR1 GLIS2 GRM1 HRAS IGFBP5 KAT2A KCNE3 KDELR2 KDM1A LATS2 MAP1B MAP1S MAP2K3 MAP2K6 MAPK8 MDM2 MET MOAP1 MST1 MYC NF2 NUDT10 PRKDC RAF1 RASSF5 RELA RHOA RHOU SMARCA4 STK11 STK4 SUV39H1 SUV39H2 TEAD2 TERT TNFRSF10A TNFRSF1A TSC1 TUBB TUBG1 XPA
Entrez ID		493	11186
HPRD ID		00159	05470
Ensembl ID		ENSG00000058668	ENSG00000068028
Uniprot IDs		P23634	Q9NS23
PDB IDs		1CFF 2KNE	2KZU
Enriched GO Terms of Interacting Partners?		Ionotropic Glutamate Receptor Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Cell Adhesion GMP Kinase Activity Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Cell Polarity GDP Metabolic Process Protein Localization To Synapse Cell Junction Protein Localization To Cell Junction Basolateral Plasma Membrane Kinase Binding Postsynaptic Density Membrane GMP Metabolic Process Synaptic Signaling Regulation Of Biological Quality Positive Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Adherens Junction Cell-cell Junction Synapse Scaffold Protein Binding Regulation Of Transport Plasma Membrane Regulation Of Vesicle-mediated Transport Nucleoside Monophosphate Metabolic Process Postsynaptic Density Ribonucleoside Diphosphate Metabolic Process Regulation Of System Process Glutamatergic Synapse Nucleoside Diphosphate Metabolic Process Cell-cell Signaling Basement Membrane Juxtaparanode Region Of Axon Signaling Intracellular Protein Localization Cell Periphery Regulation Of Endocytosis Cell Communication Chemical Synaptic Transmission Protein Localization To Membrane Cellular Response To Potassium Ion Sarcolemma Neuron Projection Trans-synaptic Signaling Regulation Of Metal Ion Transport	Regulation Of Cell Cycle Intracellular Signal Transduction Protein Kinase Activity Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Protein Serine Kinase Activity Response To UV Regulation Of Signal Transduction By P53 Class Mediator Signal Transduction Regulation Of Mitotic Cell Cycle Response To Radiation Cellular Response To Radiation Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Cellular Response To UV Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Regulation Of Apoptotic Process Programmed Cell Death Nucleotide Binding Cell Death Cellular Response To Light Stimulus Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Response To Light Stimulus Apoptotic Process Apoptotic Signaling Pathway Cell Cycle Phase Transition Cellular Response To Stress Positive Regulation Of Cellular Component Organization Regulation Of Catalytic Activity ATP Binding Negative Regulation Of Signal Transduction Transferase Activity Regulation Of Protein Phosphorylation Mitotic Cell Cycle Phase Transition
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