ATP2B4 and DLG2

Number of citations of the paper that reports this interaction (PMID 11274188)
36

Data Source:
HPRD (in vivo, in vitro)

		ATP2B4	DLG2
Gene Name		ATPase, Ca++ transporting, plasma membrane 4	discs, large homolog 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Z Disc T-tubule Protein Complex	Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Juxtaparanode Region Of Axon Postsynaptic Membrane
	Molecular Function	Calcium-transporting ATPase Activity Protein Binding Calmodulin Binding ATP Binding Sodium Channel Regulator Activity Protein Phosphatase 2B Binding Nitric-oxide Synthase Inhibitor Activity Metal Ion Binding Nitric-oxide Synthase Binding Scaffold Protein Binding	Guanylate Kinase Activity Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Cellular Calcium Ion Homeostasis Blood Coagulation Metabolic Process Negative Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Ion Transmembrane Transport Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Nitric-oxide Synthase Activity Response To Hydrostatic Pressure Calcium Ion Homeostasis Transmembrane Transport Calcium Ion Transmembrane Transport Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Epinephrine Stimulus Calcium Ion Import Across Plasma Membrane Negative Regulation Of The Force Of Heart Contraction Negative Regulation Of Arginine Catabolic Process Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Citrulline Biosynthetic Process Positive Regulation Of CAMP-dependent Protein Kinase Activity	Synaptic Transmission Nervous System Development Negative Regulation Of Phosphatase Activity Sensory Perception Of Pain Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse
Pathways		Ion transport by P-type ATPases Ion channel transport Platelet homeostasis Reduction of cytosolic Ca++ levels Platelet calcium homeostasis
Drugs
Diseases
GWAS		Breast size ( 22747683) Malaria ( 22895189) Mean corpuscular hemoglobin concentration ( 23263863)	Obesity-related traits ( 23251661) Parkinson's disease ( 17052657) Phospholipid levels (plasma) ( 22359512) Protein quantitative trait loci ( 18464913) Wilms tumor ( 22544364)
Protein-Protein Interactions		11 interactors: CASK CD22 DLG1 DLG2 DLG3 DLG4 ERBB2IP NOS1 PPP3CA RASSF1 SRC	40 interactors: ABCA1 ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 ERBB4 FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 SCN4A SCN5A SEMA4C WNT3A
Entrez ID		493	1740
HPRD ID		00159	04663
Ensembl ID		ENSG00000058668	ENSG00000150672
Uniprot IDs		P23634	B7Z2T4 E9PN83 Q15700
PDB IDs		1CFF 2KNE	2BYG 2HE2
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Establishment Or Maintenance Of Apical/basal Cell Polarity Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Cell Polarity Nucleotide Metabolic Process Synaptic Transmission Cell Adhesion Nucleobase-containing Small Molecule Metabolic Process Positive Regulation Of Transport Cellular Protein Localization Protein Localization To Membrane Axon Guidance Membrane Organization Negative Regulation Of Hydrolase Activity Regulation Of Ion Transmembrane Transport Cell-cell Signaling Organophosphate Metabolic Process Cortical Actin Cytoskeleton Organization Axonogenesis Phosphorylation Phosphate-containing Compound Metabolic Process Cortical Cytoskeleton Organization Signaling Protein Localization Positive Regulation Of Ion Transport Axon Development Cell Communication Negative Regulation Of Cell Adhesion Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Negative Regulation Of Cell-matrix Adhesion Locomotion Neuron Projection Morphogenesis Cell Cycle Regulation Of Membrane Potential Cell Morphogenesis Involved In Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of Cell-substrate Adhesion Small Molecule Metabolic Process Anatomical Structure Development Regulation Of Catalytic Activity Myotube Differentiation Regulation Of Phosphorus Metabolic Process Cellular Localization Regulation Of Synaptic Transmission	Cell-cell Signaling Synaptic Transmission Membrane Depolarization Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron-neuron Synaptic Transmission Neuromuscular Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ion Transmembrane Transport Neurological System Process Regulation Of Signaling Glutamate Receptor Signaling Pathway Startle Response Ion Transport Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signal Transduction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Sodium Ion Transmembrane Transport Nervous System Development Metal Ion Transport Transmembrane Transport Positive Regulation Of Membrane Potential Transport Negative Regulation Of Adrenergic Receptor Signaling Pathway Neuron Differentiation Cation Transmembrane Transport Protein Localization To Synapse Positive Regulation Of Transport Neurogenesis Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Regulation Of Receptor Activity Metencephalon Development Regulation Of Respiratory Gaseous Exchange Regulation Of Cellular Process Regulation Of Sodium Ion Transport Generation Of Neurons Postsynaptic Membrane Organization Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Postsynaptic Membrane Assembly
Tagcloud ?			17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Difference) ?			17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Intersection) ?