NPM1 and CDKN1A

  • Number of citations of the paper that reports this interaction (PMID 19221506)
  • 8
  • Data Source:
  • BioGRID (affinity chromatography technology, pull down, imaging technique)

NPM1

CDKN1A

Gene Name nucleophosmin (nucleolar phosphoprotein B23, numatrin) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 53 interactors: ABCC1 ACY1 ALK APP ARF1 CDK1 CDK2 CDKN1A CDT1 COX8A CSNK2A1 EIF2AK2 EIF3E ELF4 EP300 ERG GADD45A GNAI2 GRB2 GZMM HAND2 HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SREK1 TCERG1 TFAP2A TP53 UQCRH USP36 XPO1 YY1 176 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 AKT1 ALAS1 ANGPT2 APLP1 APP ATP5B ATP6V1A ATXN3 BAD BAG6 BCCIP C1orf123 CASP3 CCDC85B CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC42 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB DAPK3 DDAH2 DEAF1 DOCK7 DYNC1I1 EEF1A1 EP300 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FLAD1 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB2L1 GNB5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HIST1H1B HMGXB3 HNRNPK HOXD8 HPD IKBKG IKZF3 ING5 INPP5K KLHL23 KMT2B KRT31 LATS2 LRIF1 MAP3K5 MAPK8 MCM10 MED31 MSH2 NGFR NKD2 NMRK2 NOV NPM1 NPRL2 NR1H2 NRBP1 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 PKM POLD2 PSMA3 QARS RAB1A RAI1 RB1 RBBP4 RBM48 RNF126 RNF144B RPL18 RPL35 RPS2 S100A8 SDF4 SET SETDB1 SIPA1 SKP2 SLC25A11 SP110 SPRED1 STAT3 SUMO3 TAF5L TCF4 TEX11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TRAF1 TRIM54 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBC UBE2D1 UNC119 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431
Entrez ID 4869 1026
HPRD ID 01246 00298
Ensembl ID ENSG00000181163 ENSG00000124762
Uniprot IDs P06748 J3KQV0 P38936
PDB IDs 2LLH 2P1B 2VXD 1AXC 2ZVV 2ZVW
Enriched GO Terms of Interacting Partners?
Tagcloud ?
aggressive  aml  amplicon  consecutive  counterparts  covering  de  expands  flt3  frequent  heterogeneous  hotspots  illumina  mds  mutated  myeloid  neoplasms  next  novo  panel  prevalent  profile  profiling  ptpn11  similarly  summary  syndromes  tp53  truseq 
antigen  arf  cd24  competitively  context  e6  glioma  hairpin  inactivation  mdm2  mutated  mutates  nearly  npm  oncogenes  overexpressed  p21  papilloma  prevents  prostate  retard  reveal  shrna  silencing  silico  somatic  sv40  tp53  viral 
Tagcloud (Difference) ?
aggressive  aml  amplicon  consecutive  counterparts  covering  de  expands  flt3  frequent  heterogeneous  hotspots  illumina  mds  myeloid  neoplasms  next  novo  panel  prevalent  profile  profiling  ptpn11  similarly  summary  syndromes  truseq 
antigen  arf  cd24  competitively  context  e6  glioma  hairpin  inactivation  mdm2  mutates  nearly  npm  oncogenes  overexpressed  p21  papilloma  prevents  prostate  retard  reveal  shrna  silencing  silico  somatic  sv40  viral 
Tagcloud (Intersection) ?
mutated  tp53