NOTCH4 and ELOC

Number of citations of the paper that reports this interaction (PubMedID 22001063)
54

Data Source:
BioGRID (biochemical, fluorescent resonance energy transfer)

		NOTCH4	ELOC
Description		notch receptor 4	elongin C
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Membrane	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Cul2-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Elongin Complex
	Molecular Function	Transcription Coactivator Activity Notch Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity	Transcription Corepressor Binding Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Luteolysis Branching Involved In Blood Vessel Morphogenesis Cell Fate Determination Morphogenesis Of A Branching Structure Epithelial To Mesenchymal Transition Endothelial Cell Morphogenesis Vasculature Development Regulation Of DNA-templated Transcription Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Tissue Development Hemopoiesis Cell Differentiation Mammary Gland Development Endothelial Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Regulation Of Developmental Process Positive Regulation Of Developmental Process Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin	Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Target-directed MiRNA Degradation
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Negative regulation of NOTCH4 signaling	Formation of RNA Pol II elongation complex Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Vif-mediated degradation of APOBEC3G RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation Neddylation Regulation of expression of SLITs and ROBOs Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		A body shape index ( 34021172) Age-related macular degeneration ( 22694956) Aspartate aminotransferase levels ( 29403010) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Circulating myeloperoxidase levels (serum) ( 23620142) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Colorectal cancer ( 30529582) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Femur bone mineral density x serum urate levels interaction ( 34046847) Food antigen IgG levels ( 24962563) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Iron status biomarkers (iron levels) ( 28334935) Joint mobility (Beighton score) ( 27182965) Longevity ( 30294719) Lung cancer ( 31577861 28604730) Lung cancer in ever smokers ( 28604730) Lupus nephritis in systemic lupus erythematosus ( 24925725) Migraine ( 27322543) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Obesity-related traits ( 23251661) Objective response to lithium treatment in bipolar disorder ( 26503763) Prostate cancer ( 23535732) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 23894747 19571808 30285260) Soluble receptor for advanced glycation end-product levels ( 26083729) Squamous cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 32771030 21408207) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Type 1 diabetes (age at diagnosis) ( 33179336) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908 24837172) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		13 interacting genes: DLL4 EGFL7 ELOC FBXW7 MAML1 MAML2 MAML3 PSEN1 PSEN2 RBPJ SMAD2 SMAD3 SMAD4	40 interacting genes: ASB11 BRD4 CBX5 CEBPA CENPC COMMD1 CPTP CUL2 CUL5 CYP2J2 ECT2 EFNB3 ELOA2 ELOA3P ELOB EPOR GHR ID2 JTB LRRC41 MCM7 MED8 METTL21C MRAS NEURL2 NOTCH4 PRAME RBX1 RCAN2 RNF7 SAT2 SERTAD1 SOCS1 SOCS3 SOCS6 USP33 USP51 VHL WNT7B ZYG11B
Entrez ID		4855	6921
HPRD ID		01290	02875
Ensembl ID		ENSG00000204301	ENSG00000154582
Uniprot IDs		A0A1U9X983 Q99466	Q15369
PDB IDs		7OR3 7OR5 7OR7	1LM8 1LQB 1VCB 2C9W 2IZV 2MA9 3DCG 3ZKJ 3ZNG 3ZRC 3ZRF 3ZTC 3ZTD 3ZUN 4AJY 4AWJ 4B95 4B9K 4BKS 4BKT 4N9F 4W9C 4W9D 4W9E 4W9F 4W9G 4W9H 4W9I 4W9J 4W9K 4W9L 4WQO 5BO4 5LLI 5N4W 5NVV 5NVW 5NVX 5NVY 5NVZ 5NW0 5NW1 5NW2 5T35 6BVB 6C5X 6FMI 6FMJ 6FMK 6GFX 6GFY 6GFZ 6GMN 6GMQ 6GMR 6GMX 6HAX 6HAY 6HR2 6I4X 6I5J 6I5N 6I7R 6P59 6R7F 6R7H 6R7N 6SIS 6V9H 6ZHC 7CJB 7JTO 7JTP 7KHH 7M6T 7PI4 7PLO 7Q2J 7S4E 7UPN 7Z6L 7Z76 7Z77 7ZLM 7ZLN 7ZLO 7ZLP 7ZLR 7ZLS 7ZNT 8BB2 8BB3 8BB4 8BB5 8BDI 8BDJ 8BDL 8BDM 8BDN 8BDO 8BDS 8BDT 8BDX 8BEB 8C13 8CQE 8CQK 8CQL 8CX0 8CX1 8CX2 8EBN 8EI3 8EWV 8FVI 8FVJ 8FY0 8FY1 8FY2 8G1P 8G1Q 8IJ1 8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV 8JE1 8JE2 8OEV 8OEW 8OF0 8OKX 8OL1 8P0F 8PC2 8PQL 8Q7R 8QJR 8QJS 8QU8 8QVU 8QW6 8QW7 8R5H 8RWZ 8RX0 8SH2 8SZK 8VL9 8VLB 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH 8Y1U 8YMB 8ZV8 8ZVJ 9BJU 9BOL 9D1I 9D1Y 9D1Z 9D8P 9EQJ 9EQM 9IPW
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Protein Complex Positive Regulation Of Transcription By RNA Polymerase II Heteromeric SMAD Protein Complex Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regionalization I-SMAD Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Blood Vessel Lumenization Anterior/posterior Pattern Specification Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding MAML1-RBP-Jkappa- ICN1 Complex Activin Responsive Factor Complex SMAD Protein Signal Transduction Paraxial Mesoderm Morphogenesis R-SMAD Binding Regulation Of Notch Signaling Pathway Activin Receptor Signaling Pathway Pattern Specification Process Tissue Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endoderm Development Positive Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Transcription Regulator Complex Epithelial Tube Morphogenesis Embryonic Morphogenesis Regulation Of Gene Expression Mesoderm Morphogenesis Regulation Of Macromolecule Biosynthetic Process Neuron Fate Commitment Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Primary Metabolic Process Negative Regulation Of Ossification Pericardium Development Aspartic Endopeptidase Activity, Intramembrane Cleaving Negative Regulation Of Macromolecule Biosynthetic Process Ventricular Cardiac Muscle Tissue Morphogenesis	Post-translational Protein Modification Protein Ubiquitination Cul2-RING Ubiquitin Ligase Complex Protein Modification By Small Protein Conjugation Cul5-RING Ubiquitin Ligase Complex VCB Complex Proteolysis Involved In Protein Catabolic Process Protein Modification Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cytokine-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Catabolic Process Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Protein K11-linked Ubiquitination Proteolysis Regulation Of Cell Differentiation Macromolecule Catabolic Process Cellular Response To Stress Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cullin-RING Ubiquitin Ligase Complex Negative Regulation Of Focal Adhesion Disassembly SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Elongin Complex NEDD8 Ligase Activity Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Regulation Of Receptor Signaling Pathway Via JAK-STAT Signal Transduction Negative Regulation Of Receptor Signaling Pathway Via STAT Macromolecule Metabolic Process NEDD8 Transferase Activity Cell Surface Receptor Signaling Pathway Via STAT Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Differentiation
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