Wiki-Pi
About
Search
People
Updates
Search
NOTCH4
Description
notch receptor 4
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Nucleus
Nucleoplasm
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Cell Surface
Membrane
Molecular Function
Transcription Coactivator Activity
Notch Binding
Calcium Ion Binding
Protein Binding
Signaling Receptor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Luteolysis
Branching Involved In Blood Vessel Morphogenesis
Cell Fate Determination
Morphogenesis Of A Branching Structure
Epithelial To Mesenchymal Transition
Endothelial Cell Morphogenesis
Vasculature Development
Regulation Of DNA-templated Transcription
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Tissue Development
Hemopoiesis
Cell Differentiation
Mammary Gland Development
Endothelial Cell Differentiation
Regulation Of Cell Differentiation
Negative Regulation Of Cell Differentiation
Negative Regulation Of Endothelial Cell Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Cell Development
Regulation Of Developmental Process
Positive Regulation Of Developmental Process
Positive Regulation Of Smooth Muscle Cell Differentiation
Negative Regulation Of Cell Adhesion Molecule Production
Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways
Pre-NOTCH Processing in the Endoplasmic Reticulum
Pre-NOTCH Transcription and Translation
Pre-NOTCH Processing in Golgi
Pre-NOTCH Processing in Golgi
Notch-HLH transcription pathway
Defective LFNG causes SCDO3
NOTCH4 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
NOTCH4 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Negative regulation of NOTCH4 signaling
Negative regulation of NOTCH4 signaling
Drugs
Diseases
GWAS
A body shape index (
34021172
)
Age-related macular degeneration (
22694956
)
Aspartate aminotransferase levels (
29403010
)
Asthma (
21804548
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Blood protein levels in cardiovascular risk (
28369058
)
Chronic hepatitis B infection (
25802187
)
Circulating myeloperoxidase levels (serum) (
23620142
)
Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia (
26876947
)
Colorectal cancer (
30529582
)
Crohn's disease (
23266558
)
Epstein-Barr virus immune response (EBNA-1) (
23326239
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Food antigen IgG levels (
24962563
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
High light scatter reticulocyte count (
32888494
)
Hip circumference adjusted for BMI (
34021172
)
HIV-1 control (
20041166
)
Inflammatory bowel disease (
28067908
)
Iron status biomarkers (iron levels) (
28334935
)
Joint mobility (Beighton score) (
27182965
)
Longevity (
30294719
)
Lung cancer (
31577861
28604730
)
Lung cancer in ever smokers (
28604730
)
Lupus nephritis in systemic lupus erythematosus (
24925725
)
Migraine (
27322543
)
Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection (
25030430
)
Obesity-related traits (
23251661
)
Objective response to lithium treatment in bipolar disorder (
26503763
)
Prostate cancer (
23535732
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
27863252
)
Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) (
26651848
)
Schizophrenia (
23894747
19571808
30285260
)
Soluble receptor for advanced glycation end-product levels (
26083729
)
Squamous cell lung carcinoma (
28604730
)
Systemic lupus erythematosus (
32771030
21408207
)
Systemic sclerosis (
21779181
)
Takayasu arteritis (
25604533
)
Type 1 diabetes (age at diagnosis) (
33179336
)
Type 1 diabetes and autoimmune thyroid diseases (
25936594
)
Ulcerative colitis (
28067908
24837172
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) (
28448500
)
Waist-to-hip ratio adjusted for body mass index (
28448500
)
Novel Interacting Genes
9 novel interacting genes:
MSH5
NEU1
NFKBIL1
NFYA
PBX2
PSMB8
SLC27A4
TDP2
WWP2
Interacting Genes
13 interacting genes:
DLL4
EGFL7
ELOC
FBXW7
MAML1
MAML2
MAML3
PSEN1
PSEN2
RBPJ
SMAD2
SMAD3
SMAD4
Entrez ID
4855
HPRD ID
01290
Ensembl ID
ENSG00000204301
Uniprot IDs
A0A1U9X983
Q99466
PDB IDs
7OR3
7OR5
7OR7
Enriched GO Terms of Interacting Partners
?
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
SMAD Protein Complex
Positive Regulation Of Transcription By RNA Polymerase II
Heteromeric SMAD Protein Complex
Positive Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regionalization
I-SMAD Binding
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Blood Vessel Lumenization
Anterior/posterior Pattern Specification
Positive Regulation Of Macromolecule Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
MAML1-RBP-Jkappa- ICN1 Complex
Activin Responsive Factor Complex
SMAD Protein Signal Transduction
Paraxial Mesoderm Morphogenesis
R-SMAD Binding
Regulation Of Notch Signaling Pathway
Activin Receptor Signaling Pathway
Pattern Specification Process
Tissue Morphogenesis
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Endoderm Development
Positive Regulation Of Metabolic Process
Cell Surface Receptor Signaling Pathway
Transcription Regulator Complex
Epithelial Tube Morphogenesis
Embryonic Morphogenesis
Regulation Of Gene Expression
Mesoderm Morphogenesis
Regulation Of Macromolecule Biosynthetic Process
Neuron Fate Commitment
Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Regulation Of Primary Metabolic Process
Negative Regulation Of Ossification
Pericardium Development
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Negative Regulation Of Macromolecule Biosynthetic Process
Ventricular Cardiac Muscle Tissue Morphogenesis
Tagcloud
?