NOTCH4 and MAML3

Number of citations of the paper that reports this interaction (PMID 12370315)
33

Data Source:
HPRD (in vivo)

		NOTCH4	MAML3
Gene Name		notch 4	mastermind-like 3 (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Receptor Activity Calcium Ion Binding Protein Binding Protein Heterodimerization Activity	Transcription Coactivator Activity
	Biological Process	Patterning Of Blood Vessels Cell Fate Determination Morphogenesis Of A Branching Structure Endothelial Cell Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Notch Receptor Processing Positive Regulation Of Transcription Of Notch Receptor Target Embryo Development Gene Expression Hemopoiesis Cell Differentiation Mammary Gland Development Negative Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Transcription, DNA-templated	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Notch-HLH transcription pathway Signaling by NOTCH4 Generic Transcription Pathway Pre-NOTCH Processing in Golgi Pre-NOTCH Transcription and Translation Signaling by NOTCH Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Expression and Processing	Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 intracellular domain regulates transcription Notch-HLH transcription pathway Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH2 Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Age-related macular degeneration ( 22694956) Asthma ( 21804548) Circulating myeloperoxidase levels (serum) ( 23620142) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) HIV-1 control ( 20041166) Obesity-related traits ( 23251661) Prostate cancer ( 23535732) Schizophrenia ( 19571808 23894747) Systemic lupus erythematosus ( 21408207) Systemic sclerosis ( 21779181)	Congenital heart malformation ( 23708190)
Protein-Protein Interactions		13 interactors: DLL4 EGFL7 FBXW7 MAML1 MAML2 MAML3 PSEN1 PSEN2 RBPJ SMAD2 SMAD3 SMAD4 TCEB1	10 interactors: NFX1 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RAI1 SCMH1 SUPT5H ZBTB1 ZZZ3
Entrez ID		4855	55534
HPRD ID		01290	10066
Ensembl ID		ENSG00000204301	ENSG00000196782
Uniprot IDs		Q99466	Q96JK9 Q9NPV6
PDB IDs
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Cardiovascular System Development Tube Development Positive Regulation Of Metabolic Process Pattern Specification Process Regulation Of Transcription From RNA Polymerase II Promoter Heart Development Transcription From RNA Polymerase II Promoter Cell Fate Commitment SMAD Protein Complex Assembly Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Tube Morphogenesis Positive Regulation Of Cellular Metabolic Process Somitogenesis Regulation Of ERBB Signaling Pathway Heart Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Somite Development Anterior/posterior Pattern Specification Notch Receptor Processing Regulation Of Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Pericardium Development Segmentation Blood Vessel Lumenization Organ Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Dorsal/ventral Pattern Formation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Epithelium Development Embryonic Morphogenesis Regulation Of RNA Metabolic Process Tissue Morphogenesis Anatomical Structure Morphogenesis Negative Regulation Of Cell Proliferation Tissue Development Cell Differentiation Embryo Development Positive Regulation Of BMP Signaling Pathway Epithelial Tube Morphogenesis	Notch Receptor Processing Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Notch Signaling Pathway Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cell Fate Commitment Interleukin-4 Secretion Notch Signaling Involved In Heart Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Pulmonary Valve Morphogenesis Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Interleukin-4 Production Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Pattern Specification Process Regulation Of Endothelial Cell Differentiation Glomerulus Vasculature Development Blood Vessel Development Vasculature Development Regulation Of Hematopoietic Progenitor Cell Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Atrium Morphogenesis Inflammatory Response To Antigenic Stimulus Cytokine Secretion Heart Valve Morphogenesis Heart Valve Development Positive Regulation Of BMP Signaling Pathway
Tagcloud ?		antileukemic antiproliferative apigenin baicalein cdc2 cdk4 cdk6 chrysin division dysregulated dysregulation flavonoids galangin genistein hl illustrated jurkat k562 luteolin naringenin nb4 potencies ppa proteomic scutellarin suppresses u937 ubiquitously xiap	2c acetyltransferase activators binds box broadly catenin cdk8 coactivator coactivators connects conserved contains diverse enhancer evolutionarily interact key mads maml1 maml2 mastermind mediator mef molecule notch regulate suppressor
Tagcloud (Difference) ?		antileukemic antiproliferative apigenin baicalein cdc2 cdk4 cdk6 chrysin division dysregulated dysregulation flavonoids galangin genistein hl illustrated jurkat k562 luteolin naringenin nb4 potencies ppa proteomic scutellarin suppresses u937 ubiquitously xiap	2c acetyltransferase activators binds box broadly catenin cdk8 coactivator coactivators connects conserved contains diverse enhancer evolutionarily interact key mads maml1 maml2 mastermind mediator mef molecule notch regulate suppressor
Tagcloud (Intersection) ?