NFE2L1 and CAPN1

Number of citations of the paper that reports this interaction (PubMedID 12358155)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NFE2L1	CAPN1
Description		NFE2 like bZIP transcription factor 1	calpain 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Protein-containing Complex	Cornified Envelope Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Calpain Complex Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Lipid Binding Cholesterol Binding Protein Domain Specific Binding Identical Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Promoter-specific Chromatin Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Fructose 6-phosphate Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Glutathione Metabolic Process Heme Biosynthetic Process Regulation Of Mitotic Nuclear Division Steroid Metabolic Process Cholesterol Metabolic Process Anatomical Structure Morphogenesis Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Cellular Homeostasis Spinal Cord Motor Neuron Differentiation Glial Cell Fate Commitment Erythrocyte Differentiation Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Cholesterol Homeostasis Cysteine Transport Cell Redox Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Glucose 6-phosphate Metabolic Process Lipid Homeostasis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Cold Cellular Response To Copper Ion Cellular Response To Cholesterol Regulation Of Odontoblast Differentiation Regulation Of Nucleus Organization Regulation Of Response To Endoplasmic Reticulum Stress	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Receptor Catabolic Process Regulation Of Catalytic Activity Mammary Gland Involution Self Proteolysis NMDA Selective Glutamate Receptor Signaling Pathway
Pathways			Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Dodecyldimethylamine N-oxide	4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Fasting glucose ( 34059833) Generalized epilepsy ( 22949513) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Red blood cell count ( 32888494)	Urate levels ( 31578528)
Interacting Genes		17 interacting genes: ATF4 BACH2 CAPN1 CD6 CREBZF GSK3B HCFC1 JUN JUNB JUND MAFF MAFG MAFK NFE2L3 PARVA TULP3 UBE4A	55 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KCTD7 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM
Entrez ID		4779	823
HPRD ID		01223	00253
Ensembl ID		ENSG00000082641	ENSG00000014216
Uniprot IDs		J9JIE5 Q14494	B2RDI5 B4DWH5 P07384
PDB IDs			1ZCM 2ARY 7W7O 7X79 8GX3
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity Integrated Stress Response Signaling RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Factor AP-1 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Endoplasmic Reticulum Stress Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process ER-nucleus Signaling Pathway DNA Binding Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Release From Viral Latency Positive Regulation Of RNA Metabolic Process Cellular Response To Metal Ion Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Cellular Response To Calcium Ion Positive Regulation Of Biosynthetic Process Cellular Response To Stress Regulation Of Primary Metabolic Process General Transcription Initiation Factor Binding Transcription Regulator Complex Transcription Cis-regulatory Region Binding Intracellular Signaling Cassette DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleus Positive Regulation Of Macromolecule Metabolic Process	Organelle Organization Regulation Of Programmed Cell Death Response To Alcohol Regulation Of Organelle Organization Regulation Of Apoptotic Process Identical Protein Binding Positive Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Protease Binding Cytoplasm Regulation Of Signal Transduction Regulation Of Cellular Component Organization Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Amino Acid Stimulus Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Programmed Cell Death Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Hepatocyte Apoptotic Process Cytosol Regulation Of Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Cell Junction Maintenance Regulation Of Renin Secretion Into Blood Stream Regulation Of Autophagy Sarcomere Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Mitochondrial Membrane Permeability G-protein Beta-subunit Binding Regulation Of Protein Localization Response To Amino Acid Release Of Cytochrome C From Mitochondria Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Fluoride Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Apoptotic Process Cellular Component Maintenance Regulation Of Membrane Permeability Cysteine-type Peptidase Activity Positive Regulation Of Cellular Component Organization Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Protein Localization
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