NFE2L1

Description		NFE2 like bZIP transcription factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Lipid Binding Cholesterol Binding Protein Domain Specific Binding Identical Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Fructose 6-phosphate Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Glutathione Metabolic Process Heme Biosynthetic Process Regulation Of Mitotic Nuclear Division Steroid Metabolic Process Cholesterol Metabolic Process Anatomical Structure Morphogenesis Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Cellular Homeostasis Spinal Cord Motor Neuron Differentiation Glial Cell Fate Commitment Erythrocyte Differentiation Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Cholesterol Homeostasis Cysteine Transport Cell Redox Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Glucose 6-phosphate Metabolic Process Lipid Homeostasis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Cold Cellular Response To Copper Ion Cellular Response To Cholesterol Regulation Of Odontoblast Differentiation Regulation Of Nucleus Organization Regulation Of Response To Endoplasmic Reticulum Stress
Pathways
Drugs		Dodecyldimethylamine N-oxide
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Fasting glucose ( 34059833) Generalized epilepsy ( 22949513) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		17 interacting genes: ATF4 BACH2 CAPN1 CD6 CREBZF GSK3B HCFC1 JUN JUNB JUND MAFF MAFG MAFK NFE2L3 PARVA TULP3 UBE4A
Entrez ID		4779
HPRD ID		01223
Ensembl ID		ENSG00000082641
Uniprot IDs		J9JIE5 Q14494
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity Integrated Stress Response Signaling RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Factor AP-1 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Endoplasmic Reticulum Stress Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process ER-nucleus Signaling Pathway DNA Binding Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Release From Viral Latency Positive Regulation Of RNA Metabolic Process Cellular Response To Metal Ion Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Cellular Response To Calcium Ion Positive Regulation Of Biosynthetic Process Cellular Response To Stress Regulation Of Primary Metabolic Process General Transcription Initiation Factor Binding Transcription Regulator Complex Transcription Cis-regulatory Region Binding Intracellular Signaling Cassette DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleus Positive Regulation Of Macromolecule Metabolic Process
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