DCLRE1C and TP53BP1

Number of citations of the paper that reports this interaction (PMID 15574327)
164

Data Source:
HPRD (in vivo)

		DCLRE1C	TP53BP1
Gene Name		DNA cross-link repair 1C	tumor protein p53 binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity 5'-3' Exonuclease Activity	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Cofactor Activity P53 Binding Damaged DNA Binding Protein Binding Methylated Histone Binding Telomeric DNA Binding
	Biological Process	Telomere Maintenance DNA Catabolic Process, Endonucleolytic Double-strand Break Repair Response To Ionizing Radiation B Cell Differentiation V(D)J Recombination Nucleic Acid Phosphodiester Bond Hydrolysis	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways			Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ATM ATR BRCA1 DDB1 DDB2 MRE11A NBN PRKDC PSMD9 RAD50 TP53BP1	34 interactors: ARAP1 ATM BLM BRCA1 CCNB1 CDK1 CRB2 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AFX HIST1H4A HIST2H4A HIST4H4 IFI16 LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 PAXIP1 PCNT PLK1 RAD18 RELA SPAG9 TFDP1 TP53 USP28 VAC14
Entrez ID		64421	7158
HPRD ID		05817	05569
Ensembl ID		ENSG00000152457	ENSG00000067369
Uniprot IDs		B3KMX5 Q96SD1	F8VY86 Q12888
PDB IDs		3W1B 3W1G 4HTP	1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 3LGF 3LGL 3LH0
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair DNA Repair DNA Recombination Cellular Response To Stress DNA Damage Checkpoint DNA Metabolic Process Cell Cycle Checkpoint Telomere Maintenance Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Response To Stress G2 DNA Damage Checkpoint Cell Cycle Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Cell Cycle Response To Radiation Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Mitotic G2 DNA Damage Checkpoint Chromosome Organization Nitrogen Compound Metabolic Process Signal Transduction By P53 Class Mediator Regulation Of Protein Autophosphorylation Regulation Of Cellular Protein Metabolic Process Response To Ionizing Radiation DNA Catabolic Process Cellular Response To Radiation Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Heterocycle Metabolic Process Reciprocal Meiotic Recombination Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway Response To Gamma Radiation Meiotic Cell Cycle Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint	Cell Cycle Cellular Response To DNA Damage Stimulus Cellular Response To Stress Response To Ionizing Radiation Mitotic Cell Cycle Cell Cycle Process DNA Damage Checkpoint DNA Metabolic Process Response To Abiotic Stimulus Response To Radiation Mitotic Cell Cycle Process Cell Cycle Checkpoint DNA Repair Nucleobase-containing Compound Metabolic Process Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Cellular Nitrogen Compound Metabolic Process Double-strand Break Repair Response To Stress Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Cell Death Telomere Maintenance Death Apoptotic Signaling Pathway DNA Recombination Intracellular Signal Transduction Regulation Of Metabolic Process G2 DNA Damage Checkpoint Chromatin Organization Mitotic Cell Cycle Phase Transition Histone Modification Cell Cycle Phase Transition Apoptotic Process DNA Conformation Change Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Programmed Cell Death DNA Packaging Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		alleles breakpoints carrier casp3 catabolism cdh19 centered cnv cnvs cyp2c19 cyp450 dab2ip deletion differed disrupted disturbed encodes estradiol exact finnish inherited itga9 multiplex nested northern participating qpcr singletons unselected	abstract adenocarcinoma bonferroni carcinogenesis cardia cc confirm correction ga gc gca genotype genotypes ldr ligation needed nucleotide p21 p73 polymorphisms remained remaining replication rs1059234 rs3176352 rs560191 rs762623 snps tt
Tagcloud (Difference) ?		alleles breakpoints carrier casp3 catabolism cdh19 centered cnv cnvs cyp2c19 cyp450 dab2ip deletion differed disrupted disturbed encodes estradiol exact finnish inherited itga9 multiplex nested northern participating qpcr singletons unselected	abstract adenocarcinoma bonferroni carcinogenesis cardia cc confirm correction ga gc gca genotype genotypes ldr ligation needed nucleotide p21 p73 polymorphisms remained remaining replication rs1059234 rs3176352 rs560191 rs762623 snps tt
Tagcloud (Intersection) ?