DCLRE1C and PRKDC

Number of citations: 0 (PubMedID 15936993)
Data Source: HPRD (in vitro, in vivo)

		DCLRE1C	PRKDC
Name		DNA cross-link repair 1C	protein kinase, DNA-activated, catalytic subunit
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Nonhomologous End Joining Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex DNA-dependent Protein Kinase Complex Nonhomologous End Joining Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity Damaged DNA Binding Nuclease Activity Endonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity 5'-3' DNA Exonuclease Activity	Nucleotide Binding DNA Binding Double-stranded DNA Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Enzyme Binding Protein Domain Specific Binding U3 SnoRNA Binding Histone H2AXS139 Kinase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Telomere Maintenance Adaptive Immune Response Immune System Process DNA Metabolic Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Response To Ionizing Radiation B Cell Differentiation V(D)J Recombination Interstrand Cross-link Repair Chromosome Organization	Maturation Of 5.8S RRNA Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Somitogenesis Negative Regulation Of Protein Phosphorylation Activation Of Innate Immune Response B Cell Lineage Commitment Immature B Cell Differentiation Pro-B Cell Differentiation T Cell Lineage Commitment Immune System Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Protein Phosphorylation DNA Damage Response Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ionizing Radiation Response To Gamma Radiation Telomere Capping Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Lymphocyte Differentiation Replication Fork Processing Mitotic G1 DNA Damage Checkpoint Signaling Protein Destabilization Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Small-subunit Processome Assembly Ectopic Germ Cell Programmed Cell Death Protein Modification Process Ribosome Biogenesis Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Regulation Of Smooth Muscle Cell Proliferation Regulation Of Epithelial Cell Proliferation Protein Localization To Chromatin Regulation Of Cellular Response To Stress Double-strand Break Repair Via Alternative Nonhomologous End Joining DNA Repair-dependent Chromatin Remodeling CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Platelet Formation Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Nonhomologous End-Joining (NHEJ)	Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) E3 ubiquitin ligases ubiquitinate target proteins
Drugs		None	Caffeine SF1126
Diseases		T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis	None
GWAS		Lymphocyte count ( 32888494 ) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309 )	Adult body size ( 32376654 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hemoglobin ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 )
Interacting Genes		10 interacting genes: ATM ATR BRCA1 CDKN1B DDB2 MRE11 NBN PRKDC RAD50 TP53BP1	94 interacting genes: ABL1 AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CCNB1 CEBPA CHEK1 CHEK2 CHUK CIB1 CLK1 CTDP1 DCAF1 DCLRE1C DUX4 E4F1 EIF2S2 EIF4EBP1 EP300 ERG FH GSK3A GSK3B GZMB H1-1 H1-2 H2AX HDAC3 HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB IKBKG ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11 MTNR1B NBN NCF1 NCF2 NCF4 NCOA6 NEIL3 NR3C1 PARP1 PCNA PDX1 PGR PIDD1 POU2F1 PPP6R1 PPP6R3 PRKAG1 PRKCD PTEN RAD17 RASSF1 RNF10 RPA1 RPA2 SGO1 SP1 SRF SUMO2 THRA THRB TP53 TREX1 TTC3 UBE2I USF1 WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ ZBTB7A
Entrez ID		64421	5591
HPRD ID		05817	02941
Ensembl ID		ENSG00000152457	ENSG00000253729
Uniprot IDs		A0A8V8TKN9 A0A8V8TLX1 B3KMX5 Q96SD1	P78527
PDB IDs		3W1B 3W1G 4HTP 6TT5 6WNL 6WO0 7ABS 7AF1 7AFS 7AFU 7AGI 7APV 7SGL 7TYR	5LUQ 5W1R 5Y3R 6ZFP 6ZH2 6ZH4 6ZH6 6ZH8 6ZHA 6ZHE 7K0Y 7K10 7K11 7K19 7K1B 7K1J 7K1K 7K1N 7LT3 7NFC 7NFE 7OTM 7OTP 7OTV 7OTW 7OTY 7SGL 7SU3 7SUD 7TYR 7Z87 7Z88 8BH3 8BHV 8BHY 8BOT 8EZ9 8EZA 8EZB 8RD4
GO Terms Enriched among Interactors		DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of DNA Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Signaling Double-strand Break Repair DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Regulation Of DNA Metabolic Process Mitotic G2/M Transition Checkpoint Negative Regulation Of Cell Cycle Process DNA Repair Regulation Of Double-strand Break Repair Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition BRCA1-C Complex Negative Regulation Of Cell Cycle G2/M Phase Transition Chromosome, Telomeric Region DNA Metabolic Process Regulation Of Cell Cycle Process Telomere Maintenance Homologous Recombination Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Telomere Organization Regulation Of Cellular Response To Stress Cellular Response To Stress Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Repair Recombinational Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cell Cycle Histone H2AXS139 Kinase Activity Chromatin Remodeling Mitotic DNA Damage Checkpoint Signaling Chromosome Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Telomere Maintenance Chromosomal Region Telomeric 3' Overhang Formation DNA Double-strand Break Processing Protein Localization To Site Of Double-strand Break Chromatin Organization Positive Regulation Of Double-strand Break Repair	Nucleus Cellular Response To Stress Nucleoplasm Regulation Of Primary Metabolic Process DNA Damage Response Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Stress DNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Damaged DNA Binding Double-strand Break Repair Nucleic Acid Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Regulation Of DNA Metabolic Process DNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Response To Radiation Chromosome Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process DNA Recombination Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Ionizing Radiation Response To Hormone Signal Transduction In Response To DNA Damage Negative Regulation Of Macromolecule Biosynthetic Process DNA Damage Checkpoint Signaling Regulation Of Cellular Response To Stress Negative Regulation Of Biosynthetic Process Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Enzyme Binding