DCLRE1C

Description		DNA cross-link repair 1C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Nonhomologous End Joining Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity Damaged DNA Binding Nuclease Activity Endonuclease Activity Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity 5'-3' DNA Exonuclease Activity
	Biological Process	Telomere Maintenance Adaptive Immune Response Immune System Process DNA Metabolic Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Response To Ionizing Radiation B Cell Differentiation V(D)J Recombination Interstrand Cross-link Repair Chromosome Organization
Pathways		Nonhomologous End-Joining (NHEJ)
Drugs
Diseases		T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Lymphocyte count ( 32888494) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		10 interacting genes: ATM ATR BRCA1 CDKN1B DDB2 MRE11 NBN PRKDC RAD50 TP53BP1
Entrez ID		64421
HPRD ID		05817
Ensembl ID		ENSG00000152457
Uniprot IDs		A0A8V8TKN9 A0A8V8TLX1 B3KMX5 Q96SD1
PDB IDs		3W1B 3W1G 4HTP 6TT5 6WNL 6WO0 7ABS 7AF1 7AFS 7AFU 7AGI 7APV 7SGL 7TYR
Enriched GO Terms of Interacting Partners?		DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of DNA Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Signaling Double-strand Break Repair DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Regulation Of DNA Metabolic Process Mitotic G2/M Transition Checkpoint Negative Regulation Of Cell Cycle Process DNA Repair Regulation Of Double-strand Break Repair Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition BRCA1-C Complex Negative Regulation Of Cell Cycle G2/M Phase Transition Chromosome, Telomeric Region DNA Metabolic Process Regulation Of Cell Cycle Process Telomere Maintenance Homologous Recombination Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Cell Cycle Telomere Organization Regulation Of Cellular Response To Stress Cellular Response To Stress Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Repair Recombinational Repair Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cell Cycle Histone H2AXS139 Kinase Activity Chromatin Remodeling Mitotic DNA Damage Checkpoint Signaling Chromosome Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Telomere Maintenance Chromosomal Region Telomeric 3' Overhang Formation DNA Double-strand Break Processing Protein Localization To Site Of Double-strand Break Chromatin Organization Positive Regulation Of Double-strand Break Repair
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