DES and BAG5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DES	BAG5
Description		desmin	BAG cochaperone 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Fascia Adherens Intercalated Disc Membrane Z Disc Neuromuscular Junction Sarcolemma Contractile Muscle Fiber Intermediate Filament Cytoskeleton Cell Tip Extracellular Exosome Cardiac Myofibril Supramolecular Fiber	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Inclusion Body Junctional Membrane Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein-folding Chaperone Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Muscle Contraction Nuclear Envelope Organization Cytoskeleton Organization Regulation Of Heart Contraction Intermediate Filament Organization Skeletal Muscle Organ Development	Protein Folding Golgi Organization Negative Regulation Of Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Negative Regulation Of Protein Refolding Regulation Of Inclusion Body Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Striated Muscle Contraction	Regulation of HSF1-mediated heat shock response
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Dilated cardiomyopathy (DCM) Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Scapuloperoneal myopathy (SPM)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Broad depression or schizophrenia ( 30626913) Depression ( 29700475) Schizophrenia ( 25056061)
Interacting Genes		58 interacting genes: AURKB BAG5 BRCA1 C1orf216 CAPN1 CDC73 CLIP4 CRYAB CT55 CWF19L2 DDX6 DSP DUX1 DUX4 EHHADH ENO1 GOLGA6L9 HSPB1 ITSN1 KRT13 KRT15 KRT20 KRT33B KRT37 LBX1 LENG1 LMO4 LONRF3 M1AP MAPKAPK2 NEB NEFL NEK6 PIAS2 PIH1D2 PKD1 PLEKHA5 POLR2G PPL PPP1R18 PRPH RNF4 ROCK1 S100A1 S100B SHBG SNAPIN SPTAN1 SYNC SYNM TCEA2 TFIP11 TRIM55 TRIM63 TRIM7 UBE2I YES1 ZMYM5	19 interacting genes: BANP CDCA7L CIRBP CREBBP DES EFEMP1 FAM118B GOLGA6A KASH5 KRTAP5-4 LRRK1 PINK1 PRKN SNCA STUB1 THAP1 TP53 TRIM27 VCP
Entrez ID		1674	9529
HPRD ID		00514	04862
Ensembl ID		ENSG00000175084	ENSG00000166170
Uniprot IDs		P17661 Q53SB5	A0A024R6M6 Q9UL15
PDB IDs			2D9D 3A8Y
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Intermediate Filament Organization Structural Constituent Of Cytoskeleton Structural Molecule Activity Contractile Muscle Fiber Cytoskeleton Organization M Band Cytoskeleton Structural Constituent Of Skin Epidermis Protein Binding Z Disc Supramolecular Fiber Organization Keratin Filament Cytoplasm Intermediate Filament Cytoskeleton Cornified Envelope Tissue Morphogenesis Organelle Organization Morphogenesis Of An Epithelium Extracellular Exosome Anterograde Axonal Transport	Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Positive Regulation Of ATP Biosynthetic Process Identical Protein Binding Dopamine Transport Regulation Of Purine Nucleotide Metabolic Process Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Mitophagy Cellular Response To Hydrogen Sulfide Regulation Of ATP Biosynthetic Process Regulation Of Dopamine Secretion Regulation Of Oxidative Phosphorylation Cellular Response To Topologically Incorrect Protein Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Aerobic Respiration Positive Regulation Of Protein-containing Complex Assembly Monoamine Transport Regulation Of Protein Stability Regulation Of Autophagy Response To Hydrogen Sulfide Negative Regulation Of Autophagy Protein Stabilization Negative Regulation Of Mitochondrial Fission Positive Regulation Of ATP Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Synaptic Vesicle Transport Regulation Of Catecholamine Secretion Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Protein-containing Complex Assembly Lewy Body Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Regulation Of Cellular Respiration Regulation Of Release Of Cytochrome C From Mitochondria Tau Protein Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Reactive Oxygen Species Metabolic Process Hsp70 Protein Binding Autophagy Ubiquitin Protein Ligase Binding Positive Regulation Of Organelle Organization Macroautophagy Inclusion Body Assembly Positive Regulation Of Small Molecule Metabolic Process Mitophagy Fibrillar Center Protein Destabilization
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