DES and DUX1

Number of citations of the paper that reports this interaction (PubMedID 26816005)
133

Data Source:
BioGRID (two hybrid, pull down)

		DES	DUX1
Description		desmin	double homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Fascia Adherens Intercalated Disc Membrane Z Disc Neuromuscular Junction Sarcolemma Contractile Muscle Fiber Intermediate Filament Cytoskeleton Cell Tip Extracellular Exosome Cardiac Myofibril Supramolecular Fiber	Nucleus
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Muscle Contraction Nuclear Envelope Organization Cytoskeleton Organization Regulation Of Heart Contraction Intermediate Filament Organization Skeletal Muscle Organ Development	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Striated Muscle Contraction
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Dilated cardiomyopathy (DCM) Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Scapuloperoneal myopathy (SPM)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624)
Interacting Genes		58 interacting genes: AURKB BAG5 BRCA1 C1orf216 CAPN1 CDC73 CLIP4 CRYAB CT55 CWF19L2 DDX6 DSP DUX1 DUX4 EHHADH ENO1 GOLGA6L9 HSPB1 ITSN1 KRT13 KRT15 KRT20 KRT33B KRT37 LBX1 LENG1 LMO4 LONRF3 M1AP MAPKAPK2 NEB NEFL NEK6 PIAS2 PIH1D2 PKD1 PLEKHA5 POLR2G PPL PPP1R18 PRPH RNF4 ROCK1 S100A1 S100B SHBG SNAPIN SPTAN1 SYNC SYNM TCEA2 TFIP11 TRIM55 TRIM63 TRIM7 UBE2I YES1 ZMYM5	5 interacting genes: ACTN2 ACTN3 CENPE CSNK2B DES
Entrez ID		1674	26584
HPRD ID		00514	10609
Ensembl ID		ENSG00000175084
Uniprot IDs		P17661 Q53SB5	O43812
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Intermediate Filament Organization Structural Constituent Of Cytoskeleton Structural Molecule Activity Contractile Muscle Fiber Cytoskeleton Organization M Band Cytoskeleton Structural Constituent Of Skin Epidermis Protein Binding Z Disc Supramolecular Fiber Organization Keratin Filament Cytoplasm Intermediate Filament Cytoskeleton Cornified Envelope Tissue Morphogenesis Organelle Organization Morphogenesis Of An Epithelium Extracellular Exosome Anterograde Axonal Transport	Z Disc Pseudopodium Focal Adhesion Assembly Structural Constituent Of Muscle Cell-substrate Junction Organization Cytoskeleton Organization Cell-substrate Junction Assembly Sarcomere Cortical Actin Cytoskeleton Cytoskeletal Protein Binding Actin Filament Actin Filament Uncapping Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Muscle Cell Development Titin Z Domain Binding Identical Protein Binding Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Transmembrane Transporter Binding Integrin Binding Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Bone Mineralization Involved In Bone Maturation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Extracellular Exosome Microspike Assembly Mitotic Chromosome Movement Towards Spindle Pole Positive Regulation Of Endocytic Recycling Organelle Organization Actin Filament Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Protein Domain Specific Binding Cell Junction Assembly Cell Junction Channel Activator Activity FATZ Binding Cellular Component Assembly LIM Domain Binding Negative Regulation Of Relaxation Of Muscle Response To Muscle Inactivity Response To Denervation Involved In Regulation Of Muscle Adaptation Muscle System Process Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Transition Between Fast And Slow Fiber Regulation Of Skeletal Muscle Tissue Growth Skeletal Muscle Atrophy Skeletal Muscle Adaptation
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