DES and SYNM

Number of citations of the paper that reports this interaction (PubMedID 11353857)
36

Data Source:
HPRD (in vitro)

		DES	SYNM
Description		desmin	synemin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Fascia Adherens Intercalated Disc Membrane Z Disc Neuromuscular Junction Sarcolemma Contractile Muscle Fiber Intermediate Filament Cytoskeleton Cell Tip Extracellular Exosome Cardiac Myofibril Supramolecular Fiber	Cytoplasm Cytoskeleton Intermediate Filament Adherens Junction Membrane Sarcolemma Costamere Intermediate Filament Cytoskeleton Neurofilament Cytoskeleton Anchoring Junction
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Vinculin Binding Intermediate Filament Binding
	Biological Process	Muscle Contraction Nuclear Envelope Organization Cytoskeleton Organization Regulation Of Heart Contraction Intermediate Filament Organization Skeletal Muscle Organ Development	Fast-twitch Skeletal Muscle Fiber Contraction Intermediate Filament Cytoskeleton Organization
Pathways		Striated Muscle Contraction
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Dilated cardiomyopathy (DCM) Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Scapuloperoneal myopathy (SPM)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624)	Carotid plaque burden ( 28282560) Low high density lipoprotein cholesterol levels ( 26879886)
Interacting Genes		58 interacting genes: AURKB BAG5 BRCA1 C1orf216 CAPN1 CDC73 CLIP4 CRYAB CT55 CWF19L2 DDX6 DSP DUX1 DUX4 EHHADH ENO1 GOLGA6L9 HSPB1 ITSN1 KRT13 KRT15 KRT20 KRT33B KRT37 LBX1 LENG1 LMO4 LONRF3 M1AP MAPKAPK2 NEB NEFL NEK6 PIAS2 PIH1D2 PKD1 PLEKHA5 POLR2G PPL PPP1R18 PRPH RNF4 ROCK1 S100A1 S100B SHBG SNAPIN SPTAN1 SYNC SYNM TCEA2 TFIP11 TRIM55 TRIM63 TRIM7 UBE2I YES1 ZMYM5	6 interacting genes: DES DTNA ERBB2 ERBB3 ERBB4 PKNOX1
Entrez ID		1674	23336
HPRD ID		00514	07305
Ensembl ID		ENSG00000175084	ENSG00000182253
Uniprot IDs		P17661 Q53SB5	A0A075B7B1 O15061
PDB IDs			6EWO
Enriched GO Terms of Interacting Partners?		Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Intermediate Filament Organization Structural Constituent Of Cytoskeleton Structural Molecule Activity Contractile Muscle Fiber Cytoskeleton Organization M Band Cytoskeleton Structural Constituent Of Skin Epidermis Protein Binding Z Disc Supramolecular Fiber Organization Keratin Filament Cytoplasm Intermediate Filament Cytoskeleton Cornified Envelope Tissue Morphogenesis Organelle Organization Morphogenesis Of An Epithelium Extracellular Exosome Anterograde Axonal Transport	ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Junction ERBB Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Protein Tyrosine Kinase Activity Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Peripheral Nervous System Development Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Basolateral Plasma Membrane Animal Organ Development Growth Factor Binding Intermediate Filament Cytoskeleton Heart Development Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Receptor Localization To Synapse Protein Localization To Synapse Embryonic Pattern Specification Glial Cell Development Negative Regulation Of Apoptotic Process Protein-containing Complex Localization Negative Regulation Of Programmed Cell Death Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Establishment Of Planar Polarity Involved In Nephron Morphogenesis Neuron Differentiation Plasma Membrane Regulation Of Epithelial Cell Proliferation Wound Healing Protein Localization To Cell Junction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Myelination Axon Ensheathment Positive Regulation Of Cardiac Muscle Tissue Development Central Nervous System Morphogenesis Nerve Growth Factor Production
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