DES and PPP1R18

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DES	PPP1R18
Gene Name		desmin	protein phosphatase 1, regulatory subunit 18
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Intermediate Filament Fascia Adherens Z Disc Neuromuscular Junction Sarcolemma Extracellular Vesicular Exosome	Cytoplasm Cytoskeleton
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding	Actin Binding Phosphatase Binding
	Biological Process	Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding
Pathways		Striated Muscle Contraction
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: AURKB BRCA1 CAPN1 CRYAB DSP EHHADH ITSN1 MAPKAPK2 NEB PKD1 PLEKHA5 PPP1R18 ROCK1 S100A1 S100B SHBG SPTAN1 SYNC SYNM TRIM55 TRIM63 TRIM7 UBE2I	37 interactors: CALCOCO2 CARD9 CCDC102B CCDC136 CCDC155 CCDC57 DES FAM9B FSD2 GOLGA2 HOMER3 KCTD9 KRT13 KRT15 KRT19 KRT31 KRT40 LZTS2 MID2 MTUS2 NEFL PDE4DIP PPP1CA PPP1CC SPDL1 SPERT STX11 TCF4 TEX11 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TRIM69 TSGA10 VPS52
Entrez ID		1674	170954
HPRD ID		00514	11172
Ensembl ID		ENSG00000175084	ENSG00000146112
Uniprot IDs		P17661 Q53SB5	Q6NYC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cytoskeleton Organization Intermediate Filament-based Process Apoptotic Process Programmed Cell Death Cell Death Death Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Developmental Process Response To Abiotic Stimulus Multicellular Organismal Development Muscle Contraction Execution Phase Of Apoptosis Anatomical Structure Development Muscle System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cellular Component Organization Peptidyl-serine Phosphorylation Negative Regulation Of Cell Death Regulation Of Cell Death System Development Regulation Of Microtubule Cytoskeleton Organization Cytoskeleton Organization Regulation Of Actin Filament-based Process Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule-based Process G2 DNA Damage Checkpoint Negative Regulation Of Reactive Oxygen Species Metabolic Process Intermediate Filament Cytoskeleton Organization Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Lipid Response To Steroid Hormone Actin-mediated Cell Contraction Intracellular Signal Transduction Cellular Protein Modification Process Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Histone H4-K20 Methylation Metanephric Distal Tubule Morphogenesis Positive Regulation Of Histone H4-K16 Acetylation Primary Spermatocyte Growth Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Programmed Cell Death Cell Cycle Checkpoint Chromosome Segregation Axonogenesis Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Axon Development Proteasomal Protein Catabolic Process	Cellular Component Assembly Glycogen Metabolic Process Cell Cycle Polysaccharide Metabolic Process Negative Regulation Of Viral Release From Host Cell Cytoskeleton Organization Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Triglyceride Catabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Viral Transcription Innate Immune Response Entrainment Of Circadian Clock By Photoperiod Regulation Of Viral Release From Host Cell Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Protein Ubiquitination Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Energy Reserve Metabolic Process Organelle Organization Cellular Protein Complex Assembly Protein Modification By Small Protein Conjugation Regulation Of Protein Binding Protein K63-linked Ubiquitination Cellular Macromolecular Complex Assembly Protein Trimerization Establishment Of Chromosome Localization Protein Complex Assembly Embryonic Digestive Tract Development Spliceosomal Complex Disassembly Chromosome Localization To Nuclear Envelope Involved In Synapsis Regulation Of Cellular Response To Growth Factor Stimulus Organelle Localization Cellular Localization Cell Division Regulation Of Extrinsic Apoptotic Signaling Pathway Establishment Of Localization In Cell Synapsis Response To Organic Substance Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Homologous Chromosome Segregation Single Organism Reproductive Process Chromosome Segregation Negative Regulation Of Interleukin-2 Secretion Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Embryonic Ectodermal Digestive Tract Development Cellular Carbohydrate Metabolic Process Positive Regulation Of Protein Binding Regulation Of Viral Transcription
Tagcloud ?		airways allergic arg10 asthmatic asthmatics b1 bk bronchoconstriction challenges glandular hyperreactivity inflamed kinin kinins lysylbradykinin neurally perennial permeability provocation reactivity reflexes repeated reproducible rhinitis serous sneezing surprisingly tachyphylaxis upper
Tagcloud (Difference) ?		airways allergic arg10 asthmatic asthmatics b1 bk bronchoconstriction challenges glandular hyperreactivity inflamed kinin kinins lysylbradykinin neurally perennial permeability provocation reactivity reflexes repeated reproducible rhinitis serous sneezing surprisingly tachyphylaxis upper
Tagcloud (Intersection) ?