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DES and PPP1R18
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
DES
PPP1R18
Description
desmin
protein phosphatase 1 regulatory subunit 18
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Cytoplasm
Cytosol
Cytoskeleton
Intermediate Filament
Plasma Membrane
Cell-cell Junction
Fascia Adherens
Intercalated Disc
Membrane
Z Disc
Neuromuscular Junction
Sarcolemma
Contractile Muscle Fiber
Intermediate Filament Cytoskeleton
Cell Tip
Extracellular Exosome
Cardiac Myofibril
Supramolecular Fiber
Cytoplasm
Cytoskeleton
Molecular Function
Structural Constituent Of Cytoskeleton
Protein Binding
Cytoskeletal Protein Binding
Identical Protein Binding
Actin Binding
Protein Binding
Phosphatase Binding
Biological Process
Muscle Contraction
Nuclear Envelope Organization
Cytoskeleton Organization
Regulation Of Heart Contraction
Intermediate Filament Organization
Skeletal Muscle Organ Development
Pathways
Striated Muscle Contraction
Drugs
Diseases
Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
Dilated cardiomyopathy (DCM)
Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
Scapuloperoneal myopathy (SPM)
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Resting heart rate (
27798624
)
Autism spectrum disorder or schizophrenia (
28540026
)
Chronic obstructive pulmonary disease (
33909500
)
Hemoglobin levels (
32327693
)
Lung cancer (
28604730
)
Interacting Genes
58 interacting genes:
AURKB
BAG5
BRCA1
C1orf216
CAPN1
CDC73
CLIP4
CRYAB
CT55
CWF19L2
DDX6
DSP
DUX1
DUX4
EHHADH
ENO1
GOLGA6L9
HSPB1
ITSN1
KRT13
KRT15
KRT20
KRT33B
KRT37
LBX1
LENG1
LMO4
LONRF3
M1AP
MAPKAPK2
NEB
NEFL
NEK6
PIAS2
PIH1D2
PKD1
PLEKHA5
POLR2G
PPL
PPP1R18
PRPH
RNF4
ROCK1
S100A1
S100B
SHBG
SNAPIN
SPTAN1
SYNC
SYNM
TCEA2
TFIP11
TRIM55
TRIM63
TRIM7
UBE2I
YES1
ZMYM5
80 interacting genes:
ABRA
ACTN3
BICD2
CALCOCO2
CARD9
CBY2
CCDC102B
CCDC136
CCDC57
CCDC88B
CDR2L
CEP70
COG6
DES
DZIP1
EIF3L
FAM9B
FHL5
FSD2
GCC1
GFAP
GMCL1
GOLGA2
GOLGA6L9
GOPC
GRIPAP1
GTPBP3
HAP1
HOMER3
HOOK2
HSF2BP
IKZF3
KASH5
KCTD9
KRT13
KRT15
KRT16
KRT19
KRT27
KRT31
KRT33B
KRT34
KRT36
KRT40
LDOC1
LZTS1
LZTS2
MAD1L1
MAPK1
MEOX2
MID2
MRPL38
MTUS2
NACA
NEFL
PDE4DIP
PIBF1
PLEKHF2
PPP1CA
PPP1CC
PPP1R13B
PRPH
SORBS3
SPDL1
STX11
TCF4
TEX11
TFIP11
TRAF2
TRIM23
TRIM27
TRIM54
TRIM62
TRIM69
TSC1
TSGA10
VIM
VPS52
ZMYND12
ZRANB1
Entrez ID
1674
170954
HPRD ID
00514
11172
Ensembl ID
ENSG00000175084
ENSG00000146112
Uniprot IDs
P17661
Q53SB5
A0A024RCJ8
A0A0G2JHC2
Q6NYC8
PDB IDs
Enriched GO Terms of Interacting Partners
?
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Intermediate Filament
Intermediate Filament Organization
Structural Constituent Of Cytoskeleton
Structural Molecule Activity
Contractile Muscle Fiber
Cytoskeleton Organization
M Band
Cytoskeleton
Structural Constituent Of Skin Epidermis
Protein Binding
Z Disc
Supramolecular Fiber Organization
Keratin Filament
Cytoplasm
Intermediate Filament Cytoskeleton
Cornified Envelope
Tissue Morphogenesis
Organelle Organization
Morphogenesis Of An Epithelium
Extracellular Exosome
Anterograde Axonal Transport
Cytoskeleton
Intermediate Filament Organization
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Cytoskeleton Organization
Intermediate Filament
Organelle Organization
Supramolecular Fiber Organization
Structural Constituent Of Skin Epidermis
Keratin Filament
Structural Constituent Of Cytoskeleton
Structural Molecule Activity
Protein Binding
Identical Protein Binding
Intermediate Filament Cytoskeleton
Microtubule-based Process
Centrosome
Morphogenesis Of An Epithelium
Microtubule Cytoskeleton Organization
Tissue Morphogenesis
Cytosol
Cytoplasm
Microtubule Organizing Center
Bergmann Glial Cell Differentiation
Epithelial Cell Differentiation
Microtubule Organizing Center Organization
Negative Regulation Of Viral Transcription
Intracellular Transport
Developmental Process
Regulation Of Viral Transcription
Response To Muramyl Dipeptide
Cellular Developmental Process
Positive Regulation Of Skeletal Muscle Tissue Growth
Establishment Of Localization In Cell
Developmental Process Involved In Reproduction
Establishment Of Protein Localization
Dynein Light Intermediate Chain Binding
Cytoskeleton-dependent Intracellular Transport
Kinetochore Binding
Regulation Of Autophagy
Cell Differentiation
Regulation Of Skeletal Muscle Tissue Growth
Z Disc
Intracellular Protein Localization
Protein Transport
Astrocyte Differentiation
PTW/PP1 Phosphatase Complex
Cellular Localization
Organelle Transport Along Microtubule
Cellular Response To Muramyl Dipeptide
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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