DES and S100A1

Number of citations of the paper that reports this interaction (PMID 8641565)
5

Data Source:
HPRD (in vitro)

		DES	S100A1
Gene Name		desmin	S100 calcium binding protein A1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Intermediate Filament Fascia Adherens Z Disc Neuromuscular Junction Sarcolemma Extracellular Vesicular Exosome	Nucleus Sarcoplasmic Reticulum Z Disc M Band Neuron Projection Protein Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Calcium-dependent Protein Binding ATPase Binding
	Biological Process	Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Positive Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Striated Muscle Contraction
Drugs			Olopatadine
Diseases
GWAS
Protein-Protein Interactions		23 interactors: AURKB BRCA1 CAPN1 CRYAB DSP EHHADH ITSN1 MAPKAPK2 NEB PKD1 PLEKHA5 PPP1R18 ROCK1 S100A1 S100B SHBG SPTAN1 SYNC SYNM TRIM55 TRIM63 TRIM7 UBE2I	24 interactors: ACTA1 AGER ANXA6 ATP2A2 CACYBP CAPZA1 DES FKBP4 GFAP GJA1 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM RYR1 S100A2 S100A4 S100B S100P SYN1
Entrez ID		1674	6271
HPRD ID		00514	01489
Ensembl ID		ENSG00000175084	ENSG00000160678
Uniprot IDs		P17661 Q53SB5	P23297
PDB IDs			2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX
Enriched GO Terms of Interacting Partners?		Regulation Of Cytoskeleton Organization Intermediate Filament-based Process Apoptotic Process Programmed Cell Death Cell Death Death Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Developmental Process Response To Abiotic Stimulus Multicellular Organismal Development Muscle Contraction Execution Phase Of Apoptosis Anatomical Structure Development Muscle System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Cellular Component Organization Peptidyl-serine Phosphorylation Negative Regulation Of Cell Death Regulation Of Cell Death System Development Regulation Of Microtubule Cytoskeleton Organization Cytoskeleton Organization Regulation Of Actin Filament-based Process Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule-based Process G2 DNA Damage Checkpoint Negative Regulation Of Reactive Oxygen Species Metabolic Process Intermediate Filament Cytoskeleton Organization Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Lipid Response To Steroid Hormone Actin-mediated Cell Contraction Intracellular Signal Transduction Cellular Protein Modification Process Negative Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Histone H4-K20 Methylation Metanephric Distal Tubule Morphogenesis Positive Regulation Of Histone H4-K16 Acetylation Primary Spermatocyte Growth Positive Regulation Of SUMO Transferase Activity Negative Regulation Of Programmed Cell Death Cell Cycle Checkpoint Chromosome Segregation Axonogenesis Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Axon Development Proteasomal Protein Catabolic Process	Muscle System Process Response To Abiotic Stimulus Regulation Of Cardiac Muscle Cell Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Protein Complex Assembly Sarcoplasmic Reticulum Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Muscle Contraction Relaxation Of Cardiac Muscle Regulation Of Striated Muscle Contraction Glycogen Catabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Polysaccharide Catabolic Process Calcium Ion Transport Relaxation Of Muscle Striated Muscle Tissue Development Negative Regulation Of Heart Contraction Skeletal Muscle Fiber Development Response To Hormone Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Metal Ion Muscle Tissue Development Cellular Component Assembly Myotube Cell Development Regulation Of Cellular Localization Cellular Carbohydrate Catabolic Process Regulation Of The Force Of Heart Contraction Actin-myosin Filament Sliding Muscle Filament Sliding Response To Wounding Regulation Of Ion Homeostasis Regulation Of Actin Filament-based Process Cellular Metal Ion Homeostasis Cellular Response To Alkaloid Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Astrocyte Differentiation Cytosolic Calcium Ion Homeostasis Cellular Cation Homeostasis Actin-mediated Cell Contraction Cellular Ion Homeostasis Response To Peptide Hormone Cardiac Conduction Tissue Development Negative Regulation Of Striated Muscle Tissue Development Steroid Hormone Receptor Complex Assembly Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Positive Regulation Of Schwann Cell Proliferation
Tagcloud ?		airways allergic arg10 asthmatic asthmatics b1 bk bronchoconstriction challenges glandular hyperreactivity inflamed kinin kinins lysylbradykinin neurally perennial permeability provocation reactivity reflexes repeated reproducible rhinitis serous sneezing surprisingly tachyphylaxis upper	ablation ad ascertain astrocytosis burden collectively demonstration detrimental elucidated gfap gsk3beta iba1 identifies indirectly microgliosis modulates neuroinflammation normalizing pathobiology pc12 plaque po4 psapp ryanodine ryr sensor twelve undetectable uses
Tagcloud (Difference) ?		airways allergic arg10 asthmatic asthmatics b1 bk bronchoconstriction challenges glandular hyperreactivity inflamed kinin kinins lysylbradykinin neurally perennial permeability provocation reactivity reflexes repeated reproducible rhinitis serous sneezing surprisingly tachyphylaxis upper	ablation ad ascertain astrocytosis burden collectively demonstration detrimental elucidated gfap gsk3beta iba1 identifies indirectly microgliosis modulates neuroinflammation normalizing pathobiology pc12 plaque po4 psapp ryanodine ryr sensor twelve undetectable uses
Tagcloud (Intersection) ?