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NCL and H2AFX
Number of citations of the paper that reports this interaction (PMID
23145133
)
4
Data Source:
BioGRID
(pull down)
NCL
H2AFX
Gene Name
nucleolin
H2A histone family, member X
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cell Cortex
Membrane
Ribonucleoprotein Complex
Cytoplasmic Ribonucleoprotein Granule
Extracellular Vesicular Exosome
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Molecular Function
Nucleotide Binding
RNA Binding
Protein Binding
Protein C-terminus Binding
Telomeric DNA Binding
Identical Protein Binding
Poly(A) RNA Binding
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Biological Process
Angiogenesis
Positive Regulation Of Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Attention deficit hyperactivity disorder (
23728934
)
Eating disorders (purging via substances) (
23568457
)
Protein-Protein Interactions
48 interactors:
ADAP1
ADAP2
CD3E
CD3EAP
CDK1
CDKN2A
CSNK2A1
CSNK2A2
ERG
ETS1
FMR1
GRB2
GZF1
GZMA
H2AFX
HIST1H1C
HIST2H2AC
HIST2H2BE
HIST3H3
HMGA1
IL7R
MDC1
MDK
MDM2
MYB
MYBL1
NBN
NDRG1
NPM1
NR3C1
PARP1
PPARGC1A
PPM1D
PRKCZ
PTGS1
S100A11
SREK1
SSB
STAU1
TERF2
TERT
TOP1
TP53
VHL
XRCC6
YWHAQ
ZFP36
ZNF689
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
Entrez ID
4691
3014
HPRD ID
01245
03465
Ensembl ID
ENSG00000188486
Uniprot IDs
B3KM80
P19338
Q9BQ02
P16104
PDB IDs
2FC8
2FC9
2KRR
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
Enriched GO Terms of Interacting Partners
?
Chromosome Organization
DNA Conformation Change
Positive Regulation Of Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Cell Aging
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Cell Cycle
Chromatin Organization
Response To Stimulus
Nucleobase-containing Compound Metabolic Process
Cellular Response To Stress
DNA Packaging
Cellular Response To Stimulus
Developmental Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Response To DNA Damage Stimulus
Regulation Of Gene Expression
Regulation Of Apoptotic Process
Chromatin Assembly
Telomere Maintenance
Cellular Nitrogen Compound Metabolic Process
Cell Cycle Checkpoint
Regulation Of Cell Death
Chromatin Assembly Or Disassembly
Response To Stress
Mitotic Cell Cycle Checkpoint
Regulation Of Cell Proliferation
DNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
Positive Regulation Of Cell Aging
Negative Regulation Of Gene Expression
Regulation Of Cell Cycle
Negative Regulation Of Biosynthetic Process
Aging
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Cellular Process
RNA Biosynthetic Process
Cellular Senescence
Double-strand Break Repair
Protein Complex Assembly
DNA Damage Checkpoint
Cell Cycle Process
Regulation Of RNA Metabolic Process
Mitotic Cell Cycle Process
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Tagcloud
?
affinity
capping
corresponding
deletion
eif
end
eucaryotic
fold
free
germ
hairpin
initiation
interference
leader
loop
mrna
noncoding
ovalbumin
rabbit
rate
recognition
restored
reticulocyte
secondary
sequence
structure
systems
translation
wheat
Tagcloud (Difference)
?
affinity
capping
corresponding
deletion
eif
end
eucaryotic
fold
free
germ
hairpin
initiation
interference
leader
loop
mrna
noncoding
ovalbumin
rabbit
rate
recognition
restored
reticulocyte
secondary
sequence
structure
systems
translation
wheat
Tagcloud (Intersection)
?