NCL and BCL2

Number of citations of the paper that reports this interaction (PubMedID 20571027)
56

Data Source:
BioGRID (unspecified method)

		NCL	BCL2
Description		nucleolin	BCL2 apoptosis regulator
Image
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Spliceosomal Complex Chromosome Nucleolus Cytoplasm Plasma Membrane Cell Cortex Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Macropinosome Membrane Ribonucleoprotein Complex	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Nuclear Membrane Mitochondrial Membrane Protein-containing Complex Myelin Sheath Pore Complex Bcl-2 Family Protein Complex BAD-BCL-2 Complex
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Telomeric DNA Binding PH Domain Binding Identical Protein Binding Insulin Receptor Substrate Binding DNA Topoisomerase Binding MRNA 5'-UTR Binding	Protease Binding Protein Binding Channel Activity Channel Inhibitor Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity BH3 Domain Binding Protein Phosphatase 2A Binding Molecular Adaptor Activity DNA-binding Transcription Factor Binding
	Biological Process	Angiogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Leukemia Inhibitory Factor	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Cell Morphogenesis Ossification Ovarian Follicle Development Metanephros Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Behavioral Fear Response Leukocyte Homeostasis B Cell Homeostasis B Cell Apoptotic Process Kidney Development Release Of Cytochrome C From Mitochondria Regulation Of Cell-matrix Adhesion Lymphocyte Homeostasis Lymphoid Progenitor Cell Differentiation B Cell Lineage Commitment T Cell Lineage Commitment Immune System Development Negative Regulation Of B Cell Apoptotic Process Response To Ischemia Renal System Process Melanin Metabolic Process Regulation Of Nitrogen Utilization Intracellular Calcium Ion Homeostasis Autophagy Apoptotic Process Humoral Immune Response DNA Damage Response Response To Oxidative Stress Actin Filament Organization Axonogenesis Female Pregnancy Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Apoptotic Mitochondrial Changes Response To Radiation Response To Xenobiotic Stimulus Response To Toxic Substance Post-embryonic Development Animal Organ Morphogenesis Response To Iron Ion Response To UV-B Response To Gamma Radiation Regulation Of Gene Expression Regulation Of Autophagy Negative Regulation Of Autophagy Negative Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Glycoprotein Biosynthetic Process Mesenchymal Cell Development Positive Regulation Of Neuron Maturation Smooth Muscle Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Cochlear Nucleus Development Gland Morphogenesis Hemopoiesis B Cell Differentiation T Cell Differentiation Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Melanocyte Differentiation Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Hair Follicle Morphogenesis Axon Regeneration Regulation Of Protein Stability Endoplasmic Reticulum Calcium Ion Homeostasis Glomerulus Development Negative Regulation Of Cellular PH Reduction Regulation Of Protein Localization Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process T Cell Differentiation In Thymus Osteoblast Proliferation Negative Regulation Of Osteoblast Proliferation Response To Cytokine Response To Nicotine Organ Growth Regulation Of Growth Positive Regulation Of Multicellular Organism Growth B Cell Proliferation Cellular Response To Glucose Starvation Response To Hydrogen Peroxide Neuron Maturation Regulation Of Apoptotic Process T Cell Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death CD8-positive, Alpha-beta T Cell Lineage Commitment Pigmentation Negative Regulation Of Neuron Apoptotic Process Ear Development Regulation Of Viral Genome Replication Positive Regulation Of Melanocyte Differentiation Negative Regulation Of Mitotic Cell Cycle Retinal Cell Programmed Cell Death Negative Regulation Of Retinal Cell Programmed Cell Death Regulation Of Mitochondrial Membrane Permeability Focal Adhesion Assembly Developmental Pigmentation Regulation Of Developmental Pigmentation Positive Regulation Of Developmental Pigmentation Spleen Development Thymus Development Response To Steroid Hormone Digestive Tract Morphogenesis Developmental Growth Oocyte Development Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Pigment Granule Organization Stem Cell Development Homeostasis Of Number Of Cells Within A Tissue B Cell Receptor Signaling Pathway Response To Glucocorticoid Neuron Apoptotic Process Defense Response To Virus Establishment Of Localization In Cell Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Depolarization Regulation Of Calcium Ion Transport Hematopoietic Stem Cell Differentiation Calcium Ion Transport Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Lymphocyte Apoptotic Process Negative Regulation Of Lymphocyte Apoptotic Process T Cell Apoptotic Process Negative Regulation Of T Cell Apoptotic Process Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Dendritic Cell Apoptotic Process Motor Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Intracellular Signal Transduction Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Dendritic Cell Apoptotic Process Negative Regulation Of Motor Neuron Apoptotic Process Negative Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol Respiratory syncytial virus (RSV) attachment and entry	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling NFE2L2 regulating tumorigenic genes Regulation of MITF-M-dependent genes involved in apoptosis
Drugs			Ibuprofen Paclitaxel Docetaxel Rasagiline AN-9 Paclitaxel docosahexaenoic acid Apoptone Eribulin Dexibuprofen Venetoclax Obatoclax Navitoclax Terpinen-4-ol Oleandrin
Diseases			Cervical cancer Kaposi's sarcoma Chronic lymphocytic leukemia (CLL) Gastric cancer Nasopharyngeal cancer Choriocarcinoma Small cell lung cancer
GWAS		Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 23728934) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Eating disorders (purging via substances) ( 23568457) Hearing loss in noise exposure ( 26121033) Height ( 31562340) Hip index ( 34021172)	A body shape index ( 34021172) Adult body size ( 32376654) Alanine aminotransferase levels ( 34315874 33547301) Albumin-globulin ratio ( 29403010) Aspartate aminotransferase levels ( 34315874 33547301) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Body mass index ( 28892062 25673413) Body mass index and fasting insulin (pairwise) ( 33619380) Body mass index and triglycerides (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Cardiac Troponin-T levels ( 23247143) Chronic lymphocytic leukemia ( 23770605 28165464 26956414) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Excessive hairiness ( 29895819) Fasting insulin ( 34059833) Follicular lymphoma ( 25279986) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip index ( 34021172) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 27863252 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 28346444) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Prostate cancer ( 29892016) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Red blood cell count ( 32888494 27863252) Response to adalimumab in hidradenitis suppurativa (abscess and inflammatory nodule count increase) ( 31465739) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Serum omega-6 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Serum total protein levels ( 29403010) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Two-hour glucose ( 34059833) Type 2 diabetes ( 28869590) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		61 interacting genes: ADAP1 ADAP2 BCL2 CD3E CDK1 CDKN2A CLK1 CSNK2A1 CSNK2A2 DANCR DUX4 ERG ESR1 ETS1 FMR1 GRB2 GZF1 GZMA H1-2 H2AC20 H2AX H2BC21 H3-4 HMGA1 IL7R ISG15 LINC01554 MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 OGT PARP1 PPARGC1A PPM1D PRKCZ PRMT5 PTGS1 RAD51 RNF10 S100A11 SREK1 SRPK2 SSB STAU1 SUMO2 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZFP41 ZNF689	89 interacting genes: ATP2A2 BAD BAG1 BAG3 BAG4 BAG6 BAK1 BAX BBC3 BCAP31 BCL2L1 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BFAR BID BIK BLK BMF BNIP1 BNIP2 BNIP3 BNIP3L BNIPL CAPN2 CASP3 CASP8 CDK1 CDK2 CPT1A CYCS FKBP8 HRAS HRK HSPA1A ITM2B ITPR1 KRAS MAPK1 MAPK11 MAPK14 MAPK3 MAPK8 MEX3D MOAP1 MYC NCL NLRP1 NMT2 NR4A1 NRAS PARP1 PIN1 PKMYT1 PMAIP1 PML PPARA PPID PPP1CA PPP2CA PPP2R5A PPP3CA PPP3CC PRKACA PRKCA PSEN1 PXN RAD9A RAF1 RNF183 RRAS RTN4 SEPTIN4 SF1 SIVA1 SMN1 SOD1 SPHK2 SPNS1 SQSTM1 TMBIM6 TOMM20 TP53 TP53AIP1 TP53BP2 XIAP
Entrez ID		4691	596
HPRD ID		01245	01045
Ensembl ID		ENSG00000115053	ENSG00000171791
Uniprot IDs		B3KM80 P19338	A0A7I2V3S7 P10415
PDB IDs		2FC8 2FC9 2KRR	1G5M 1GJH 1YSW 2O21 2O22 2O2F 2W3L 2XA0 4AQ3 4IEH 4LVT 4LXD 4MAN 5AGW 5AGX 5FCG 5JSN 5VAU 5VAX 5VAY 6GL8 6IWB 6O0K 6O0L 6O0M 6O0O 6O0P 7LHB 7Y90 7YA5 8FY1 8FY2 8HLL 8HLM 8HLN 8HOG 8HOH 8HOI 8HTR 8HTS 8IQL 8U27 8VWX 8VWZ 8VXM 8VXN
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Response To Stress Chromatin Organization Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Metabolic Process Chromosome DNA Damage Response Regulation Of Cell Population Proliferation Cellular Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Protein Localization To Site Of Double-strand Break Protein Localization To Organelle DNA Binding Chromosome, Telomeric Region Regulation Of RNA Metabolic Process Chromatin Remodeling Response To Gamma Radiation Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Recombination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Ionizing Radiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process DNA Metabolic Process Protein Localization To Chromosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Positive Regulation Of Gene Expression DNA Repair Negative Regulation Of DNA Metabolic Process Macromolecule Metabolic Process	Apoptotic Process Programmed Cell Death Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Apoptotic Signaling Pathway Cellular Response To Stress Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Response To Stress Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrion Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Regulation Of Intracellular Signal Transduction Mitochondrial Outer Membrane Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization Negative Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Signal Transduction Positive Regulation Of Signaling Apoptotic Mitochondrial Changes Positive Regulation Of Cell Communication Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Membrane Permeability Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Intracellular Signal Transduction Mitochondrial Membrane Organization Regulation Of Cellular Component Organization Mitochondrion Organization Regulation Of Membrane Permeability Release Of Cytochrome C From Mitochondria DNA Damage Response Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Response To Decreased Oxygen Levels Regulation Of Cellular Response To Stress Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Response To Oxygen Levels Cytosol
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