NCL and MYBL1

Number of citations of the paper that reports this interaction (PubMedID 10660576)
0

Data Source:
BioGRID (affinity chromatography technology, far western blotting)
HPRD (in vitro, in vivo)

		NCL	MYBL1
Description		nucleolin	MYB proto-oncogene like 1
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Spliceosomal Complex Chromosome Nucleolus Cytoplasm Plasma Membrane Cell Cortex Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Macropinosome Membrane Ribonucleoprotein Complex	Nucleus Nucleoplasm
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Telomeric DNA Binding PH Domain Binding Identical Protein Binding Insulin Receptor Substrate Binding DNA Topoisomerase Binding MRNA 5'-UTR Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding
	Biological Process	Angiogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Leukemia Inhibitory Factor	Mitotic Cell Cycle Regulation Of DNA-templated Transcription Male Meiosis I Spermatogenesis Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of PiRNA Transcription
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol Respiratory syncytial virus (RSV) attachment and entry	PIWI-interacting RNA (piRNA) biogenesis
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 23728934) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Eating disorders (purging via substances) ( 23568457) Hearing loss in noise exposure ( 26121033) Height ( 31562340) Hip index ( 34021172)
Interacting Genes		61 interacting genes: ADAP1 ADAP2 BCL2 CD3E CDK1 CDKN2A CLK1 CSNK2A1 CSNK2A2 DANCR DUX4 ERG ESR1 ETS1 FMR1 GRB2 GZF1 GZMA H1-2 H2AC20 H2AX H2BC21 H3-4 HMGA1 IL7R ISG15 LINC01554 MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 OGT PARP1 PPARGC1A PPM1D PRKCZ PRMT5 PTGS1 RAD51 RNF10 S100A11 SREK1 SRPK2 SSB STAU1 SUMO2 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZFP41 ZNF689	4 interacting genes: CREBBP HIPK2 NCL NLK
Entrez ID		4691	4603
HPRD ID		01245	08868
Ensembl ID		ENSG00000115053	ENSG00000185697
Uniprot IDs		B3KM80 P19338	P10243 Q495G0
PDB IDs		2FC8 2FC9 2KRR
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Response To Stress Chromatin Organization Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Metabolic Process Chromosome DNA Damage Response Regulation Of Cell Population Proliferation Cellular Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Protein Localization To Site Of Double-strand Break Protein Localization To Organelle DNA Binding Chromosome, Telomeric Region Regulation Of RNA Metabolic Process Chromatin Remodeling Response To Gamma Radiation Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Recombination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Ionizing Radiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process DNA Metabolic Process Protein Localization To Chromosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Positive Regulation Of Gene Expression DNA Repair Negative Regulation Of DNA Metabolic Process Macromolecule Metabolic Process	Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Histone H3K18 Acetyltransferase Activity Intracellular Signaling Cassette N-terminal Peptidyl-lysine Acetylation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Macropinosome Membrane Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription Corepressor Activity Regulation Of Signal Transduction DNA Topoisomerase Binding Lens Induction In Camera-type Eye Wnt Signaling Pathway, Calcium Modulating Pathway MRF Binding Regulation Of DNA-templated Transcription Protein Stabilization Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Transcription Coactivator Activity Regulation Of RNA Metabolic Process Cellular Response To Nutrient Levels Regulation Of Signaling Positive Regulation Of Transcription By RNA Polymerase II Embryonic Retina Morphogenesis In Camera-type Eye PML Body Organization Voluntary Musculoskeletal Movement Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Hypoxia Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription By RNA Polymerase I Response To Oxygen Levels Response To Decreased Oxygen Levels Negative Regulation Of Signal Transduction PH Domain Binding Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Cell Communication Negative Regulation Of Signaling Virion Binding Protein Serine Kinase Activity Protein Phosphorylation Iris Morphogenesis Peptidyl-lysine Acetylation
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