NCL and PRKCZ

Number of citations of the paper that reports this interaction (PubMedID 9388266)
0

Data Source:
HPRD (in vivo, in vitro)

		NCL	PRKCZ
Description		nucleolin	protein kinase C zeta
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Nucleus Nucleoplasm Spliceosomal Complex Chromosome Nucleolus Cytoplasm Plasma Membrane Cell Cortex Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Macropinosome Membrane Ribonucleoprotein Complex	Nucleus Nuclear Envelope Cytoplasm Endosome Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Bicellular Tight Junction Cilium Cell Cortex Membrane Apical Plasma Membrane Nuclear Matrix Cell Junction Vesicle Myelin Sheath Abaxonal Region Ciliary Basal Body Axon Hillock Apical Cortex Extracellular Exosome Tight Junction Anchoring Junction PAR Polarity Complex
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Telomeric DNA Binding PH Domain Binding Identical Protein Binding Insulin Receptor Substrate Binding DNA Topoisomerase Binding MRNA 5'-UTR Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Insulin Receptor Substrate Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Angiogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Leukemia Inhibitory Factor	Microtubule Cytoskeleton Organization Protein Phosphorylation Inflammatory Response Signal Transduction Establishment Of Cell Polarity Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Long-term Synaptic Potentiation Positive Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Neuron Projection Extension Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol Respiratory syncytial virus (RSV) attachment and entry	GPVI-mediated activation cascade TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Estrogen-stimulated signaling through PRKCZ Estrogen-stimulated signaling through PRKCZ
Drugs			Tamoxifen Staurosporine Dequalinium Benzoyl peroxide
Diseases
GWAS		Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 23728934) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Eating disorders (purging via substances) ( 23568457) Hearing loss in noise exposure ( 26121033) Height ( 31562340) Hip index ( 34021172)	Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Height ( 20881960) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		61 interacting genes: ADAP1 ADAP2 BCL2 CD3E CDK1 CDKN2A CLK1 CSNK2A1 CSNK2A2 DANCR DUX4 ERG ESR1 ETS1 FMR1 GRB2 GZF1 GZMA H1-2 H2AC20 H2AX H2BC21 H3-4 HMGA1 IL7R ISG15 LINC01554 MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 OGT PARP1 PPARGC1A PPM1D PRKCZ PRMT5 PTGS1 RAD51 RNF10 S100A11 SREK1 SRPK2 SSB STAU1 SUMO2 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZFP41 ZNF689	91 interacting genes: ADAP1 ADCY5 AFAP1 AKT1 AKT3 BLVRA BTK C1QBP CASP3 CASP6 CASP7 CASP8 CASP9 CDC42 CHAT CREBBP CSNK2B DAPK3 DENND5A EGFR FADD FEZ1 FEZ2 FRS2 FYN GABARAP GLRX3 GRB14 GRM5 GSK3A GSK3B H1-1 H1-5 HABP4 HDAC6 HRAS IKBKB IL4R IRAK1 IRS1 IRS4 JAK1 KRT10 LRRK2 MAP1LC3B MAP2K1 MAP2K5 MAPK1 MAPK3 MAPK7 MAPT MBP NCF1 NCL NCOA3 NFATC2 NMT2 NUMB PARD6A PARD6B PARD6G PAWR PDLIM7 PDPK1 PEBP1 PIAS4 PPP1R14A PPP3CA PRG2 PRKCA PRKCD PSEN1 RAF1 RELA RHOA SLC39A1 SP1 SQSTM1 SRC STAT6 STUB1 TIAM1 TRAF6 UBC UTP14A VMA22 WWC1 YWHAB YWHAQ YWHAZ ZNF71
Entrez ID		4691	5590
HPRD ID		01245	01504
Ensembl ID		ENSG00000115053	ENSG00000067606
Uniprot IDs		B3KM80 P19338	Q05513
PDB IDs		2FC8 2FC9 2KRR
Enriched GO Terms of Interacting Partners?		Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Response To Stress Chromatin Organization Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm Negative Regulation Of Metabolic Process Chromosome DNA Damage Response Regulation Of Cell Population Proliferation Cellular Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process Signal Transduction In Response To DNA Damage Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Protein Localization To Site Of Double-strand Break Protein Localization To Organelle DNA Binding Chromosome, Telomeric Region Regulation Of RNA Metabolic Process Chromatin Remodeling Response To Gamma Radiation Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Recombination Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Ionizing Radiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process DNA Metabolic Process Protein Localization To Chromosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Positive Regulation Of Gene Expression DNA Repair Negative Regulation Of DNA Metabolic Process Macromolecule Metabolic Process	Cytosol Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Cellular Localization Enzyme-linked Receptor Protein Signaling Pathway Insulin Receptor Signaling Pathway Protein Kinase Activity Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Protein Localization Positive Regulation Of Cell Migration Phosphorylation Regulation Of Cell-cell Adhesion Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Motility Response To Lipid Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Regulation Of Immune System Process Positive Regulation Of Locomotion Regulation Of Cell Migration Activation Of Immune Response Regulation Of Locomotion Kinase Activity Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Signal Transduction Response To Stress
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