MT3 and TERF2IP

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		MT3	TERF2IP
Gene Name		metallothionein 3	telomeric repeat binding factor 2, interacting protein
Image
Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Synaptic Vesicle Inclusion Body Perinuclear Region Of Cytoplasm	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mre11 Complex
	Molecular Function	Copper Ion Binding Protein Binding Drug Binding Zinc Ion Binding Antioxidant Activity Protein Kinase Activator Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Cadmium Ion Binding	Protein Binding Telomeric DNA Binding
	Biological Process	Protein Import Into Nucleus, Translocation Response To Hypoxia Positive Regulation Of Protein Phosphorylation Energy Reserve Metabolic Process Cholesterol Catabolic Process Zinc Ion Transport Cellular Metal Ion Homeostasis Cellular Zinc Ion Homeostasis Cell Proliferation Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Necrotic Cell Death Positive Regulation Of Cell Death Astrocyte Development Histone Modification Removal Of Superoxide Radicals Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Response To Food Activation Of Protein Kinase B Activity Leptin-mediated Signaling Pathway Cellular Response To Oxidative Stress Cellular Response To Drug Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Cellular Lipid Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Stabilization Negative Regulation Of Oxidoreductase Activity Zinc Ion Homeostasis Cadmium Ion Homeostasis Regulation Of Protein Glycosylation Negative Regulation Of Necrotic Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cadmium Ion Cellular Response To Hypoxia Cellular Response To Nitric Oxide Positive Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Oxygen Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	Telomere Maintenance Transcription, DNA-templated Regulation Of Transcription, DNA-templated Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Protection From Non-homologous End Joining At Telomere Negative Regulation Of Telomere Maintenance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region
Pathways			Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: TERF2IP TTR	125 interactors: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 C9orf78 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DHX38 DNMT3A DPP3 ENAH EPAS1 EPS8L1 FABP2 FAM122A GAGE5 GAMT GNMT GPKOW HAAO HAGH HDGFRP3 HIST1H1A HIST1H2AL HIST1H4B HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NUDT14 NUDT18 NUMA1 NXNL1 OCM2 OGFR PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PML PNMT POLD1 PPM1G PPP1R2 PPP6R3 PRDX6 PRX PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SMARCC2 SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 XRCC6 ZNF146 ZNF414
Entrez ID		4504	54386
HPRD ID		00752	05452
Ensembl ID		ENSG00000087250	ENSG00000166848
Uniprot IDs		P25713	Q9NYB0
PDB IDs		2F5H 2FJ4 2FJ5	1FEX 3K6G
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Protection From Non-homologous End Joining At Telomere Thyroid Hormone Transport Protein Localization To Chromosome, Telomeric Region Telomere Capping Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Recombination Retinol Metabolic Process Regulation Of Double-strand Break Repair Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Repair Regulation Of DNA Recombination Phototransduction, Visible Light Telomere Maintenance Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Negative Regulation Of Chromosome Organization Hormone Transport Phototransduction Negative Regulation Of DNA Metabolic Process Detection Of Light Stimulus Isoprenoid Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Response To DNA Damage Stimulus	Chromosome Organization Telomere Maintenance Cellular Nitrogen Compound Metabolic Process Organelle Organization Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Chromatin Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process DNA Conformation Change Chromatin Modification Cell Cycle Cellular Response To Stress DNA Metabolic Process Cellular Response To DNA Damage Stimulus Sequestering Of Actin Monomers DNA Recombination Telomere Maintenance Via Telomere Lengthening Catabolic Process DNA Duplex Unwinding Cellular Aldehyde Metabolic Process Cellular Hyperosmotic Salinity Response DNA Geometric Change DNA Replication Energy Reserve Metabolic Process Nucleosome Organization Organophosphate Catabolic Process Response To Stress Chromatin Assembly Or Disassembly Deoxyribose Phosphate Catabolic Process Cellular Localization Cellular Metabolic Process Protein Localization To Nucleus Glycogen Metabolic Process Nucleocytoplasmic Transport Chromatin Remodeling Base-excision Repair Cellular Response To X-ray Nuclear Transport Aromatic Compound Catabolic Process Nucleosome Assembly Deoxyribonucleotide Catabolic Process DNA Strand Elongation Involved In DNA Replication Small Molecule Metabolic Process DNA Strand Elongation Biosynthetic Process Chromatin Assembly Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Transport Energy Derivation By Oxidation Of Organic Compounds
Tagcloud ?		125i abstract augmented column cytotrophoblasts eluted elution exclusively explants hcg hpl immunocytochemical immunoreactive localized pcna placental placentas proliferating proliferative secrete syncytiotrophoblasts thyronine triiodo trophoblastic trophoblasts villous week words	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates
Tagcloud (Difference) ?		125i abstract augmented column cytotrophoblasts eluted elution exclusively explants hcg hpl immunocytochemical immunoreactive localized pcna placental placentas proliferating proliferative secrete syncytiotrophoblasts thyronine triiodo trophoblastic trophoblasts villous week words	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 tinf tinf2 yates
Tagcloud (Intersection) ?