MT3 and TERF2IP

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		MT3	TERF2IP
Description		metallothionein 3	TERF2 interacting protein
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrial Outer Membrane Cytosol Ribosome Microtubule Synaptic Vesicle Inclusion Body Axon Dendritic Spine Perinuclear Region Of Cytoplasm Astrocyte Projection Astrocyte End-foot	Nuclear Chromosome Chromosome, Telomeric Region Nuclear Telomere Cap Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Body Shelterin Complex
	Molecular Function	Copper Ion Binding Protein Binding Zinc Ion Binding Antioxidant Activity Protein Kinase Activator Activity Cadmium Ion Binding Metal Ion Binding Metal Ion Sequestering Activity	Protein Binding Phosphatase Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Energy Reserve Metabolic Process Zinc Ion Transport Intracellular Zinc Ion Homeostasis Response To Oxidative Stress Detoxification Of Copper Ion Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Removal Of Superoxide Radicals Intracellular Monoatomic Cation Homeostasis Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Response To Food Activation Of Protein Kinase B Activity Leptin-mediated Signaling Pathway Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Neurogenesis Protein Stabilization Negative Regulation Of Oxidoreductase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion Cellular Response To Hypoxia Detoxification Of Cadmium Ion Cellular Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Oxygen Metabolic Process	Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of DNA-templated Transcription Telomere Maintenance Via Telomerase Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Telomere Capping Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		Metallothioneins bind metals Metallothioneins bind metals	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs		Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Weight ( 34074324)
Interacting Genes		2 interacting genes: TERF2IP TTR	122 interacting genes: ADA AIMP2 AK1 AKR1A1 AKR1B10 AKR7A3 AKT1 ANXA5 ANXA8L1 AP2B1 APEX1 ARPP21 BABAM1 BANP BCL7B C1orf174 CALML3 CHMP2B COTL1 CPNE2 CPNE3 CRK CRYBB1 CRYGS CTBP1 DBNL DDX23 DDX24 DDX39A DNMT3A DPP3 ENAH EPAS1 EPS8L1 ETS2 FABP2 GAGE5 GAMT GNMT H1-1 H2AC16 H4C2 HAAO HAGH HDGFL3 HMGB1 HMGB3 HMGN3 HMGN4 HNRNPK IDO1 IL1RN LANCL2 LGALSL MAGOHB MCM2 MDH1 MPG MRTO4 MT1X MT3 NAIF1 NASP NOL3 NPSR1 NUDT14 NUDT18 NXNL1 OCM2 OGFR PABIR1 PACSIN2 PACSIN3 PAFAH1B3 PCNP PCP4 PEA15 PGLS PGM1 PIAS1 PML PNMT PPP1R2 PPP6R3 PRDX6 PRX PTEN PTMA RABIF RAD50 RASSF5 RBBP9 RECQL4 RGMA RIF1 RPAP1 RPP25 S100P SBDS SCLY SCRN2 SET SNCG SP100 TALDO1 TBC1D10A TBCA TERF2 TMSB10 TMSB4Y TOR1AIP1 TSSC4 TWF2 UCHL1 VGLL4 WDR5 WIPI2 XAGE2 XPO1 XRCC5 ZNF146 ZNF414
Entrez ID		4504	54386
HPRD ID		00752	05452
Ensembl ID		ENSG00000087250	ENSG00000166848
Uniprot IDs		P25713	Q9NYB0
PDB IDs		2F5H 2FJ4 2FJ5	1FEX 3K6G 4RQI 7OZ0 8RD4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Glomerular Filtration Molecular Sequestering Activity Hormone Binding Phototransduction, Visible Light Regulation Of Glomerular Filtration Protein Localization To Chromosome, Telomeric Region Telomere Maintenance In Response To DNA Damage Nuclear Telomere Cap Complex Protection From Non-homologous End Joining At Telomere Shelterin Complex Telomere Capping G-rich Strand Telomeric DNA Binding Purine Nucleobase Metabolic Process Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Telomere Maintenance Via Telomerase Detection Of Visible Light RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Nuclear Chromosome Phototransduction Negative Regulation Of Telomere Maintenance Phosphatase Binding Negative Regulation Of DNA Recombination Male Germ Cell Nucleus Detection Of Light Stimulus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Retinoid Metabolic Process Positive Regulation Of Telomere Maintenance Diterpenoid Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Chromosome Organization Regulation Of Double-strand Break Repair Via Homologous Recombination Azurophil Granule Lumen DNA Biosynthetic Process Terpenoid Metabolic Process Isoprenoid Metabolic Process Hormone Activity Negative Regulation Of Protein Phosphorylation Telomere Maintenance Protein Localization To Chromosome Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Chromosome Organization Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Telomere Maintenance Renal System Process Detection Of Abiotic Stimulus Negative Regulation Of Phosphorylation Telomere Organization	Cytoplasm Protein Binding Cytosol Double-stranded Telomeric DNA Binding Nucleobase-containing Compound Metabolic Process Chromatin Organization Chromosome, Telomeric Region Telomere Organization Chromatin Remodeling Protein Domain Specific Binding Nucleus Telomere Maintenance Nucleoplasm Energy Reserve Metabolic Process Chromosome Organization Glycogen Metabolic Process Alcohol Dehydrogenase (NADP+) Activity Cellular Detoxification Of Aldehyde Extracellular Exosome Telomere Maintenance In Response To DNA Damage Myelin Maintenance Negative Regulation Of T-circle Formation Polysaccharide Metabolic Process Nucleic Acid Metabolic Process Nicotinamide Nucleotide Metabolic Process Maintenance Of Protein Localization In Organelle DNA Metabolic Process Plasma Membrane Organization Quinolinate Biosynthetic Process Allyl-alcohol Dehydrogenase Activity DNA Recombination Helicase Activity Regulation Of Growth Generation Of Precursor Metabolites And Energy Calcium-dependent Phospholipid Binding Negative Regulation Of DNA Metabolic Process Cadherin Binding Regulation Of Cellular Response To Stress Quinolinate Metabolic Process Mre11 Complex Negative Regulation Of Cellular Component Organization Carbohydrate Metabolic Process Regulation Of Cell Growth Actin Monomer Binding Positive Regulation Of Proteolysis Maintenance Of Protein Location In Cell RNA-templated DNA Biosynthetic Process
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