MT3 and TTR

Number of citations of the paper that reports this interaction (PMID 20646067)
1

Data Source:
BioGRID (pull down)

		MT3	TTR
Gene Name		metallothionein 3	transthyretin
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Gene Ontology Annotations	Cellular Component	Intracellular Cytoplasm Synaptic Vesicle Inclusion Body Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Cytoplasm Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Copper Ion Binding Protein Binding Drug Binding Zinc Ion Binding Antioxidant Activity Protein Kinase Activator Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Cadmium Ion Binding	Hormone Activity Protein Binding Identical Protein Binding Protein Heterodimerization Activity Thyroid Hormone Binding
	Biological Process	Protein Import Into Nucleus, Translocation Response To Hypoxia Positive Regulation Of Protein Phosphorylation Energy Reserve Metabolic Process Cholesterol Catabolic Process Zinc Ion Transport Cellular Metal Ion Homeostasis Cellular Zinc Ion Homeostasis Cell Proliferation Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Necrotic Cell Death Positive Regulation Of Cell Death Astrocyte Development Histone Modification Removal Of Superoxide Radicals Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Response To Food Activation Of Protein Kinase B Activity Leptin-mediated Signaling Pathway Cellular Response To Oxidative Stress Cellular Response To Drug Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Cellular Lipid Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Stabilization Negative Regulation Of Oxidoreductase Activity Zinc Ion Homeostasis Cadmium Ion Homeostasis Regulation Of Protein Glycosylation Negative Regulation Of Necrotic Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cadmium Ion Cellular Response To Hypoxia Cellular Response To Nitric Oxide Positive Regulation Of Lysosomal Membrane Permeability Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Oxygen Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	Retinoid Metabolic Process Transport Phototransduction, Visible Light Extracellular Matrix Organization Retinol Metabolic Process Thyroid Hormone Transport
Pathways			Amyloids Visual phototransduction The canonical retinoid cycle in rods (twilight vision) Retinoid cycle disease events Non-integrin membrane-ECM interactions Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS			Retinol levels ( 21878437)
Protein-Protein Interactions		2 interactors: TERF2IP TTR	46 interactors: A2M ACTB AGER APOA1 ASNA1 ATF4 BAG6 C14orf1 CDR2 CHD3 CLU CPNE6 CTNND2 DDR1 EEF1A1 FEZ1 GET4 HNRNPH3 HSPG2 IKBKAP INPP5K KIAA1377 LRP2 MARK3 MT3 NECAB2 NGFR OTUB1 PHYHIP PIK3R1 PRKCI QARS RAI1 RBP4 RNF115 SDF4 SETDB1 SP110 ST13 ST3GAL3 SUMO3 TAF1C TAF5L TUBA1A VIM ZBED1
Entrez ID		4504	7276
HPRD ID		00752	01447
Ensembl ID		ENSG00000087250	ENSG00000118271
Uniprot IDs		P25713	E9KL36 P02766
PDB IDs		2F5H 2FJ4 2FJ5	1BM7 1BMZ 1BZ8 1BZD 1BZE 1DVQ 1DVS 1DVT 1DVU 1DVX 1DVY 1DVZ 1E3F 1E4H 1E5A 1ETA 1ETB 1F41 1F64 1F86 1FH2 1FHN 1G1O 1GKO 1ICT 1III 1IIK 1IJN 1QAB 1QWH 1RLB 1SOK 1SOQ 1THA 1THC 1TLM 1TSH 1TT6 1TTA 1TTB 1TTC 1TTR 1TYR 1TZ8 1U21 1X7S 1X7T 1Y1D 1Z7J 1ZCR 1ZD6 2B14 2B15 2B16 2B77 2B9A 2F7I 2F8I 2FBR 2FLM 2G3X 2G3Z 2G4E 2G4G 2G5U 2G9K 2GAB 2H4E 2M5N 2NOY 2PAB 2QEL 2QGB 2QGC 2QGD 2QGE 2ROX 2ROY 2TRH 2TRY 2WQA 3A4D 3A4E 3A4F 3B56 3BSZ 3BT0 3CBR 3CFM 3CFN 3CFQ 3CFT 3CN0 3CN1 3CN2 3CN3 3CN4 3CXF 3D2T 3D7P 3DGD 3DID 3DJR 3DJS 3DJT 3DJZ 3DK0 3DK2 3DO4 3ESN 3ESO 3ESP 3FC8 3FCB 3GLZ 3GPS 3GRB 3GRG 3GS0 3GS4 3GS7 3HJ0 3I9A 3I9I 3I9P 3IMR 3IMS 3IMT 3IMU 3IMV 3IMW 3IPB 3IPE 3KGS 3KGT 3KGU 3M1O 3NEE 3NEO 3NES 3NEX 3NG5 3OZK 3OZL 3P3R 3P3S 3P3T 3P3U 3SSG 3TCT 3TFB 3U2I 3U2J 3W3B 4ABQ 4ABU 4ABV 4ABW 4AC2 4AC4 4ACT 4ANK 4DER 4DES 4DET 4DEU 4DEW 4FI6 4FI7 4FI8 4HIQ 4HIS 4I85 4I87 4I89 4IIZ 4IK6 4IK7 4IKI 4IKJ 4IKK 4IKL 4KY2 4L1S 4L1T 4MAS 5TTR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Protection From Non-homologous End Joining At Telomere Thyroid Hormone Transport Protein Localization To Chromosome, Telomeric Region Telomere Capping Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Recombination Retinol Metabolic Process Regulation Of Double-strand Break Repair Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Repair Regulation Of DNA Recombination Phototransduction, Visible Light Telomere Maintenance Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Negative Regulation Of Chromosome Organization Hormone Transport Phototransduction Negative Regulation Of DNA Metabolic Process Detection Of Light Stimulus Isoprenoid Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Response To DNA Damage Stimulus	Protein Insertion Into ER Membrane Anatomical Structure Development Developmental Process Protein Stabilization Protein Metabolic Process Cellular Protein Metabolic Process Multicellular Organismal Development Regulation Of Protein Stability Nervous System Development Central Nervous System Development Regulation Of Gene Expression Protein Insertion Into Membrane System Development Cellular Localization Phototransduction, Visible Light Retinoid Metabolic Process Detection Of Abiotic Stimulus Diterpenoid Metabolic Process Detection Of Visible Light Cellular Response To Stimulus Platelet Activation Phototransduction Response To Light Stimulus Chromatin Organization Regulation Of Glucose Transport Alcohol Metabolic Process Detection Of Light Stimulus Organelle Organization Establishment Of Protein Localization To Membrane Metabolic Process Lipid Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Cellular Metabolic Process Isoprenoid Metabolic Process Response To Organic Substance Endoplasmic Reticulum Organization Chromatin Modification Regulation Of Cellular Protein Metabolic Process Membrane Organization Response To Radiation Negative Regulation Of Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Response To Wounding Signaling Regulation Of Glucose Import Cellular Protein Modification Process
Tagcloud ?		125i abstract augmented column cytotrophoblasts eluted elution exclusively explants hcg hpl immunocytochemical immunoreactive localized pcna placental placentas proliferating proliferative secrete syncytiotrophoblasts thyronine triiodo trophoblastic trophoblasts villous week words	arteriovenous carotid clamped conscious constant cooled cooling degree depend destined driving extrahypothalamic gain goats hypothalamic hypothalamus loops manipulate passage rete sbc shunt tbr temperatures termed texh thermodes thyp trunk
Tagcloud (Difference) ?		125i abstract augmented column cytotrophoblasts eluted elution exclusively explants hcg hpl immunocytochemical immunoreactive localized pcna placental placentas proliferating proliferative secrete syncytiotrophoblasts thyronine triiodo trophoblastic trophoblasts villous week words	arteriovenous carotid clamped conscious constant cooled cooling degree depend destined driving extrahypothalamic gain goats hypothalamic hypothalamus loops manipulate passage rete sbc shunt tbr temperatures termed texh thermodes thyp trunk
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