MT3

Description		metallothionein 3
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrial Outer Membrane Cytosol Ribosome Microtubule Synaptic Vesicle Inclusion Body Axon Dendritic Spine Perinuclear Region Of Cytoplasm Astrocyte Projection Astrocyte End-foot
	Molecular Function	Copper Ion Binding Protein Binding Zinc Ion Binding Antioxidant Activity Protein Kinase Activator Activity Cadmium Ion Binding Metal Ion Binding Metal Ion Sequestering Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Energy Reserve Metabolic Process Zinc Ion Transport Intracellular Zinc Ion Homeostasis Response To Oxidative Stress Detoxification Of Copper Ion Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Removal Of Superoxide Radicals Intracellular Monoatomic Cation Homeostasis Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Response To Food Activation Of Protein Kinase B Activity Leptin-mediated Signaling Pathway Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Neurogenesis Protein Stabilization Negative Regulation Of Oxidoreductase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion Cellular Response To Hypoxia Detoxification Of Cadmium Ion Cellular Detoxification Negative Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Oxygen Metabolic Process
Pathways		Metallothioneins bind metals Metallothioneins bind metals
Drugs		Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS
Interacting Genes		2 interacting genes: TERF2IP TTR
Entrez ID		4504
HPRD ID		00752
Ensembl ID		ENSG00000087250
Uniprot IDs		P25713
PDB IDs		2F5H 2FJ4 2FJ5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Glomerular Filtration Molecular Sequestering Activity Hormone Binding Phototransduction, Visible Light Regulation Of Glomerular Filtration Protein Localization To Chromosome, Telomeric Region Telomere Maintenance In Response To DNA Damage Nuclear Telomere Cap Complex Protection From Non-homologous End Joining At Telomere Shelterin Complex Telomere Capping G-rich Strand Telomeric DNA Binding Purine Nucleobase Metabolic Process Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Telomere Maintenance Via Telomerase Detection Of Visible Light RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Nuclear Chromosome Phototransduction Negative Regulation Of Telomere Maintenance Phosphatase Binding Negative Regulation Of DNA Recombination Male Germ Cell Nucleus Detection Of Light Stimulus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Retinoid Metabolic Process Positive Regulation Of Telomere Maintenance Diterpenoid Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Chromosome Organization Regulation Of Double-strand Break Repair Via Homologous Recombination Azurophil Granule Lumen DNA Biosynthetic Process Terpenoid Metabolic Process Isoprenoid Metabolic Process Hormone Activity Negative Regulation Of Protein Phosphorylation Telomere Maintenance Protein Localization To Chromosome Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Chromosome Organization Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Telomere Maintenance Renal System Process Detection Of Abiotic Stimulus Negative Regulation Of Phosphorylation Telomere Organization
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