ABCC1 and FILNC1

Number of citations of the paper that reports this interaction (PubMedID 28978906)
44

Data Source:
BioGRID (unspecified method)

		ABCC1	FILNC1
Description		ATP binding cassette subfamily C member 1 (ABCC1 blood group)	FOXO induced long non-coding RNA 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding ATP Binding ABC-type Xenobiotic Transporter Activity ABC-type Vitamin B12 Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity Efflux Transmembrane Transporter Activity Hydrolase Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Lipid Transmembrane Transporter Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sphingolipid Transporter Activity Carboxylic Acid Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Leukotriene Metabolic Process Xenobiotic Metabolic Process Lipid Transport Response To Xenobiotic Stimulus Cobalamin Transport Sphingolipid Biosynthetic Process Cellular Response To Oxidative Stress Glutathione Transmembrane Transport Heme Catabolic Process Xenobiotic Transport Phospholipid Translocation Carboxylic Acid Transport Positive Regulation Of Inflammatory Response Transmembrane Transport Cell Chemotaxis Transepithelial Transport Cyclic Nucleotide Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Sphingolipid Translocation Export Across Plasma Membrane Transport Across Blood-brain Barrier Cellular Response To Amyloid-beta Carboxylic Acid Transmembrane Transport Xenobiotic Transport Across Blood-brain Barrier
Pathways		Sphingolipid de novo biosynthesis Heme degradation Synthesis of Leukotrienes (LT) and Eoxins (EX) ABC-family proteins mediated transport Cytoprotection by HMOX1 Paracetamol ADME Transport of RCbl within the body NFE2L2 regulating MDR associated enzymes
Drugs		ATP Sulfinpyrazone Biricodar Romidepsin Leukotriene C4
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) Hip circumference adjusted for BMI ( 34021172) Ischemic stroke (undetermined subtype) ( 26708676) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple myeloma (survival) ( 26198393) Pelvic organ prolapse (moderate/severe) ( 26545240) Psychosis proneness (perceptual aberration scale) ( 28525603) Rate of ventricular enlargement ( 31711042) Red cell distribution width ( 32888494) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186) Serum metabolite levels ( 33031748) Severe autoimmune type 2 diabetes ( 34737425) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count (basophil) ( 27863252)	Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		7 interacting genes: ATP5F1A AZGP1 CSNK2A1 FILNC1 NPM1 NR3C1 TRAF3	88 interacting genes: AAAS ABCC1 ACTN1 ACTR2 AHSA1 AIMP2 AKAP8 ALDH1B1 AP1B1 AP3D1 ARAP1 ARF6 ATP2A2 CAND1 CCT6B CLPX CNDP2 COPG1 DDX24 DNM1 DNM1L DPM1 DYNC1H1 EEF1D EEF2 ERLIN1 GALK1 GMPS GSTO1 HDLBP HNRNPA0 HNRNPD HSPA1A IDH1 KTN1 LAMC1 LAS1L MAP1S MCM3 MRPL4 MSH2 MTHFD1L MYL12A NIBAN2 NKRF NOP56 NPEPPSP1 NSF NUP153 OASL OGT PCAT1 PDCD4 PES1 PFAS PLS3 PPME1 PSMC2 PSMC4 PSMD14 PSMD5 PURA QNG1 RIGI RO60 RPL13A RPS5 RPSA SART1 STT3B STXBP2 TAGLN2 TIMM50 TMEM126A TMX3 TRIP13 TTLL12 TTN U2AF1 UBA52 UBE4A VPS35 WARS1 XPO1 XPOT XRCC6 YWHAB ZCCHC8
Entrez ID		4363	100132735
HPRD ID		01153
Ensembl ID		ENSG00000103222	ENSG00000231426
Uniprot IDs		A0A7I2V2E0 P33527
PDB IDs		2CBZ 4C3Z 8VT4 8VUX 8VVC
Enriched GO Terms of Interacting Partners?		Core Promoter Sequence-specific DNA Binding Cellular Response To Dexamethasone Stimulus Response To Dexamethasone Hsp90 Protein Binding Macrophage Differentiation Adenyl Ribonucleotide Binding Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Nuclear Glucocorticoid Receptor Activity Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Cellular Response To Steroid Hormone Stimulus Protein Kinase Binding Regulation Of Endoribonuclease Activity Regulation Of Translational Initiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Signal Transduction By P53 Class Mediator	RNA Binding Cytosol ATP Hydrolysis Activity Nucleotide Binding Cadherin Binding Ribonucleoprotein Complex Ficolin-1-rich Granule Lumen ATP Binding Extracellular Exosome Proteasome Accessory Complex Cytoplasm Translation Intracellular Transport Proteasome Regulatory Particle, Base Subcomplex Secretory Granule Lumen Nucleoplasm Actin Filament Binding Macromolecule Metabolic Process Nucleolus Mitochondrion-derived Vesicle Intracellular Protein Transport Organelle Localization Cellular Localization Establishment Of Localization In Cell Proteasome Complex Nucleobase-containing Compound Metabolic Process Actin Filament Network Formation ATP-dependent Protein Disaggregase Activity Proteasome-activating Activity LncRNA Binding Membrane Coat Ribosome Cytoplasmic Translation Establishment Of Organelle Localization Double-stranded DNA Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Protein Localization ATP-dependent Protein Folding Chaperone Cellular Component Assembly Regulation Of Cytoplasmic Translation
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