ABCC1 and ATP5F1A

Number of citations of the paper that reports this interaction (PubMedID 22188235)
23

Data Source:
BioGRID (pull down)

		ABCC1	ATP5F1A
Description		ATP binding cassette subfamily C member 1 (ABCC1 blood group)	ATP synthase F1 subunit alpha
Image
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Cell Surface Membrane Proton-transporting Two-sector ATPase Complex Membrane Raft Proton-transporting ATP Synthase Complex Extracellular Exosome Transmembrane Transporter Complex
	Molecular Function	Nucleotide Binding ATP Binding ABC-type Xenobiotic Transporter Activity ABC-type Vitamin B12 Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity Efflux Transmembrane Transporter Activity Hydrolase Activity ATP Hydrolysis Activity Transmembrane Transporter Activity ATPase-coupled Lipid Transmembrane Transporter Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Sphingolipid Transporter Activity Carboxylic Acid Transmembrane Transporter Activity ABC-type Transporter Activity	Nucleotide Binding Protease Binding RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Adenyl Ribonucleotide Binding MHC Class I Protein Binding ADP Binding Angiostatin Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism
	Biological Process	Leukotriene Metabolic Process Xenobiotic Metabolic Process Lipid Transport Response To Xenobiotic Stimulus Cobalamin Transport Sphingolipid Biosynthetic Process Cellular Response To Oxidative Stress Glutathione Transmembrane Transport Heme Catabolic Process Xenobiotic Transport Phospholipid Translocation Carboxylic Acid Transport Positive Regulation Of Inflammatory Response Transmembrane Transport Cell Chemotaxis Transepithelial Transport Cyclic Nucleotide Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Sphingolipid Translocation Export Across Plasma Membrane Transport Across Blood-brain Barrier Cellular Response To Amyloid-beta Carboxylic Acid Transmembrane Transport Xenobiotic Transport Across Blood-brain Barrier	Negative Regulation Of Endothelial Cell Proliferation Lipid Metabolic Process ATP Biosynthetic Process Monoatomic Ion Transport Response To Muscle Activity Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Ethanol ATP Metabolic Process Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Proton Transmembrane Transport
Pathways		Sphingolipid de novo biosynthesis Heme degradation Synthesis of Leukotrienes (LT) and Eoxins (EX) ABC-family proteins mediated transport Cytoprotection by HMOX1 Paracetamol ADME Transport of RCbl within the body NFE2L2 regulating MDR associated enzymes	Mitochondrial protein import Formation of ATP by chemiosmotic coupling Cristae formation Mitochondrial protein degradation
Drugs		ATP Sulfinpyrazone Biricodar Romidepsin Leukotriene C4	Quercetin 1-ACETYL-2-CARBOXYPIPERIDINE AUROVERTIN B Piceatannol N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINE Artenimol
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163) Hip circumference adjusted for BMI ( 34021172) Ischemic stroke (undetermined subtype) ( 26708676) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple myeloma (survival) ( 26198393) Pelvic organ prolapse (moderate/severe) ( 26545240) Psychosis proneness (perceptual aberration scale) ( 28525603) Rate of ventricular enlargement ( 31711042) Red cell distribution width ( 32888494) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186) Serum metabolite levels ( 33031748) Severe autoimmune type 2 diabetes ( 34737425) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count (basophil) ( 27863252)
Interacting Genes		7 interacting genes: ATP5F1A AZGP1 CSNK2A1 FILNC1 NPM1 NR3C1 TRAF3	24 interacting genes: ABCC1 AIMP1 AIRE APP ATP5F1C ATPAF2 CSNK2A1 FNDC3B HSD17B10 HSPB2 LINC00941 LINC01554 NPSR1 OGT PTEN PTPRF SCGN SHBG SMARCB1 TNK2 YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		4363	498
HPRD ID		01153	01258
Ensembl ID		ENSG00000103222	ENSG00000152234
Uniprot IDs		A0A7I2V2E0 P33527	P25705 V9HW26
PDB IDs		2CBZ 4C3Z 8VT4 8VUX 8VVC	8H9E 8H9I 8H9L 8H9P 8H9S 8H9T 8H9U 8H9V 8KI3
Enriched GO Terms of Interacting Partners?		Core Promoter Sequence-specific DNA Binding Cellular Response To Dexamethasone Stimulus Response To Dexamethasone Hsp90 Protein Binding Macrophage Differentiation Adenyl Ribonucleotide Binding Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Nuclear Glucocorticoid Receptor Activity Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Cellular Response To Steroid Hormone Stimulus Protein Kinase Binding Regulation Of Endoribonuclease Activity Regulation Of Translational Initiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Protein Localization To Nucleus Protein Targeting Negative Regulation Of Translational Initiation Phosphoserine Residue Binding Protein Sequestering Activity Identical Protein Binding TORC1 Signaling Regulation Of Translation Protein Domain Specific Binding TOR Signaling Protein Localization To Vacuole Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Translational Initiation Sin3-type Complex Regulation Of TORC1 Signaling Post-transcriptional Regulation Of Gene Expression Central Tolerance Induction To Self Antigen Peripheral T Cell Tolerance Induction Positive Regulation Of Transcription By RNA Polymerase II Amyloid-beta Complex Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction Reproductive Behavior Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Negative Regulation Of Synaptic Vesicle Clustering Chondroitin Sulfate Proteoglycan Binding Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of TOR Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Glucagon Secretion Negative Regulation Of Defecation Synapse
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