FILNC1 and VPS35

Number of citations of the paper that reports this interaction (PubMedID 28978906)
44

Data Source:
BioGRID (unspecified method)

		FILNC1	VPS35
Description		FOXO induced long non-coding RNA 1	VPS35 retromer complex component
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Postsynaptic Density Membrane Retromer Complex Retromer, Cargo-selective Complex Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Tubular Endosome Dopaminergic Synapse Presynapse Postsynapse Glutamatergic Synapse Mitochondrion-derived Vesicle
	Molecular Function		Protein Binding D1 Dopamine Receptor Binding
	Biological Process		Intracellular Protein Transport Lysosome Organization Positive Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Protein Transport Wnt Signaling Pathway Regulation Of Macroautophagy Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Negative Regulation Of Protein Homooligomerization Protein Localization To Organelle Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Regulation Of Protein Catabolic Process Mitochondrial Fragmentation Involved In Apoptotic Process Transcytosis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Voluntary Musculoskeletal Movement Regulation Of Transport Regulation Of Protein Metabolic Process Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Wnt Protein Secretion Regulation Of Synapse Maturation Positive Regulation Of Mitochondrial Fission Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Locomotion Involved In Locomotory Behavior Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Of Postsynapse Organization Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Regulation Of Postsynapse Assembly Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Dendritic Spine Maintenance Positive Regulation Of Dopamine Biosynthetic Process Negative Regulation Of Protein Localization Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Presynapse Assembly Regulation Of Terminal Button Organization
Pathways			WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		88 interacting genes: AAAS ABCC1 ACTN1 ACTR2 AHSA1 AIMP2 AKAP8 ALDH1B1 AP1B1 AP3D1 ARAP1 ARF6 ATP2A2 CAND1 CCT6B CLPX CNDP2 COPG1 DDX24 DNM1 DNM1L DPM1 DYNC1H1 EEF1D EEF2 ERLIN1 GALK1 GMPS GSTO1 HDLBP HNRNPA0 HNRNPD HSPA1A IDH1 KTN1 LAMC1 LAS1L MAP1S MCM3 MRPL4 MSH2 MTHFD1L MYL12A NIBAN2 NKRF NOP56 NPEPPSP1 NSF NUP153 OASL OGT PCAT1 PDCD4 PES1 PFAS PLS3 PPME1 PSMC2 PSMC4 PSMD14 PSMD5 PURA QNG1 RIGI RO60 RPL13A RPS5 RPSA SART1 STT3B STXBP2 TAGLN2 TIMM50 TMEM126A TMX3 TRIP13 TTLL12 TTN U2AF1 UBA52 UBE4A VPS35 WARS1 XPO1 XPOT XRCC6 YWHAB ZCCHC8	15 interacting genes: APP DRD1 FILNC1 GNL1 LINC01554 MTNR1B PRPF19 SLC11A2 SNX1 USP7 VEGFA VPS26B VPS29 YBX1 ZNF512B
Entrez ID		100132735	55737
HPRD ID			06085
Ensembl ID		ENSG00000231426	ENSG00000069329
Uniprot IDs			Q96QK1
PDB IDs			2R17 5F0J 5F0K 5F0L 5F0M 5F0P 5OSH 5OSI 7BLN 7BLO 8R02 8R0J 8RKS
Enriched GO Terms of Interacting Partners?		RNA Binding Cytosol ATP Hydrolysis Activity Nucleotide Binding Cadherin Binding Ribonucleoprotein Complex Ficolin-1-rich Granule Lumen ATP Binding Extracellular Exosome Proteasome Accessory Complex Cytoplasm Translation Intracellular Transport Proteasome Regulatory Particle, Base Subcomplex Secretory Granule Lumen Nucleoplasm Actin Filament Binding Macromolecule Metabolic Process Nucleolus Mitochondrion-derived Vesicle Intracellular Protein Transport Organelle Localization Cellular Localization Establishment Of Localization In Cell Proteasome Complex Nucleobase-containing Compound Metabolic Process Actin Filament Network Formation ATP-dependent Protein Disaggregase Activity Proteasome-activating Activity LncRNA Binding Membrane Coat Ribosome Cytoplasmic Translation Establishment Of Organelle Localization Double-stranded DNA Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Protein Localization ATP-dependent Protein Folding Chaperone Cellular Component Assembly Regulation Of Cytoplasmic Translation	Negative Regulation Of MiRNA Transcription Retromer Complex Retromer, Cargo-selective Complex Early Endosome Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Retrograde Transport, Endosome To Golgi Mating Behavior Cellular Response To Catecholamine Stimulus Regulation Of Neurotransmitter Uptake Response To Catecholamine Insulin Receptor Binding Cytosolic Transport Positive Regulation Of Receptor Internalization Blood Vessel Diameter Maintenance Regulation Of Tube Size Late Endosome Endosome Chemoattractant Activity Reproductive Behavior Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Early Endosome Membrane Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Chemotaxis Regulation Of Protein Localization Nickel Cation Transmembrane Transporter Activity Nickel Cation Transmembrane Transport Vanadium Ion Transport Paraferritin Complex Lead Ion Transport Chromium Ion Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Vanadium Ion Transmembrane Transporter Activity VEGF-A Complex Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Basophil Chemotaxis Visual Learning Positive Regulation Of Receptor-mediated Endocytosis Vasodilation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Protein Transport Acetylcholine Receptor Activator Activity Cell Projection Morphogenesis Myeloid Cell Development Visual Behavior Learning Or Memory Platelet Alpha Granule Lumen
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