FILNC1 and RIGI

Number of citations of the paper that reports this interaction (PubMedID 28978906)
44

Data Source:
BioGRID (unspecified method)

		FILNC1	RIGI
Description		FOXO induced long non-coding RNA 1	RNA sensor RIG-I
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Actin Cytoskeleton Membrane Ruffle Membrane Cell Projection Anchoring Junction Ribonucleoprotein Complex
	Molecular Function		Nucleotide Binding Nucleic Acid Binding Double-stranded DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding GTP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Pattern Recognition Receptor Activity Identical Protein Binding Metal Ion Binding
	Biological Process		Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MRNA Transcription Detection Of Virus Response To Virus Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Migration Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production RIG-I Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response
Pathways			ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases OAS antiviral response TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses RSV-host interactions Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		88 interacting genes: AAAS ABCC1 ACTN1 ACTR2 AHSA1 AIMP2 AKAP8 ALDH1B1 AP1B1 AP3D1 ARAP1 ARF6 ATP2A2 CAND1 CCT6B CLPX CNDP2 COPG1 DDX24 DNM1 DNM1L DPM1 DYNC1H1 EEF1D EEF2 ERLIN1 GALK1 GMPS GSTO1 HDLBP HNRNPA0 HNRNPD HSPA1A IDH1 KTN1 LAMC1 LAS1L MAP1S MCM3 MRPL4 MSH2 MTHFD1L MYL12A NIBAN2 NKRF NOP56 NPEPPSP1 NSF NUP153 OASL OGT PCAT1 PDCD4 PES1 PFAS PLS3 PPME1 PSMC2 PSMC4 PSMD14 PSMD5 PURA QNG1 RIGI RO60 RPL13A RPS5 RPSA SART1 STT3B STXBP2 TAGLN2 TIMM50 TMEM126A TMX3 TRIP13 TTLL12 TTN U2AF1 UBA52 UBE4A VPS35 WARS1 XPO1 XPOT XRCC6 YWHAB ZCCHC8	21 interacting genes: CCDC50 CYLD DHX16 FILNC1 IRGM MAVS PRKCG RNF122 RNF125 RNF135 SNX5 THAP12 TRIM40 TRIM6 TRIM65 UBC UBE2D1 UBE2D2 UBE2D3 USP15 USP3
Entrez ID		100132735	23586
HPRD ID			13131
Ensembl ID		ENSG00000231426	ENSG00000107201
Uniprot IDs			A0AAQ5BIG4 O95786
PDB IDs			2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3ZD6 3ZD7 4AY2 4BPB 4NQK 4ON9 4P4H 5E3H 5F98 5F9F 5F9H 6GPG 6KYV 7BAH 7BAI 7JL1 7JL3 7MK1 7TNX 7TNY 7TNZ 7TO0 7TO1 7TO2 8DVR 8DVS 8DVU 8G7T 8G7U 8G7V 8SCZ 8SD0
Enriched GO Terms of Interacting Partners?		RNA Binding Cytosol ATP Hydrolysis Activity Nucleotide Binding Cadherin Binding Ribonucleoprotein Complex Ficolin-1-rich Granule Lumen ATP Binding Extracellular Exosome Proteasome Accessory Complex Cytoplasm Translation Intracellular Transport Proteasome Regulatory Particle, Base Subcomplex Secretory Granule Lumen Nucleoplasm Actin Filament Binding Macromolecule Metabolic Process Nucleolus Mitochondrion-derived Vesicle Intracellular Protein Transport Organelle Localization Cellular Localization Establishment Of Localization In Cell Proteasome Complex Nucleobase-containing Compound Metabolic Process Actin Filament Network Formation ATP-dependent Protein Disaggregase Activity Proteasome-activating Activity LncRNA Binding Membrane Coat Ribosome Cytoplasmic Translation Establishment Of Organelle Localization Double-stranded DNA Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Protein Localization ATP-dependent Protein Folding Chaperone Cellular Component Assembly Regulation Of Cytoplasmic Translation	Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Type I Interferon Production Protein Ubiquitination Protein Polyubiquitination Antiviral Innate Immune Response Protein K48-linked Ubiquitination Protein Metabolic Process Ubiquitin-protein Transferase Activity Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response NLRP3 Inflammasome Complex Assembly Defense Response To Symbiont Defense Response To Other Organism Macromolecule Metabolic Process Regulation Of Defense Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Virus Proteolysis Ubiquitin Conjugating Enzyme Activity Immune Response Canonical Inflammasome Complex Assembly Positive Regulation Of Interferon-beta Production Positive Regulation Of Defense Response Negative Regulation Of Type I Interferon Production Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Free Ubiquitin Chain Polymerization Macromolecule Catabolic Process Type I Interferon-mediated Signaling Pathway Response To Other Organism Pattern Recognition Receptor Signaling Pathway Regulation Of Interferon-beta Production Regulation Of Cytokine Production Positive Regulation Of Peptidyl-threonine Phosphorylation Modification-dependent Protein Catabolic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Zinc Ion Binding Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Protein Autoubiquitination Interferon-mediated Signaling Pathway Activation Of Innate Immune Response Regulation Of Immune Response CARD Domain Binding
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