ABCC1 and AZGP1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ABCC1	AZGP1
Gene Name		ATP-binding cassette, sub-family C (CFTR/MRP), member 1	alpha-2-glycoprotein 1, zinc-binding
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Plasma Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Transporter Activity ATP Binding ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances	Glycoprotein Binding Antigen Binding Ribonuclease Activity Protein Transmembrane Transporter Activity Peptide Antigen Binding
	Biological Process	Leukotriene Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Transport Cobalamin Metabolic Process Arachidonic Acid Metabolic Process Response To Drug Small Molecule Metabolic Process Transmembrane Transport	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Retina Homeostasis Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Immune Response Cell Adhesion Negative Regulation Of Cell Proliferation Antigen Processing And Presentation Protein Transmembrane Transport RNA Phosphodiester Bond Hydrolysis
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF ABC-family proteins mediated transport Metabolism of lipids and lipoproteins Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Arachidonic acid metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Synthesis of Leukotrienes (LT) and Eoxins (EX) Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism
Drugs		Sulfinpyrazone
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AZGP1 NPM1 TRAF3	4 interactors: ABCC1 ITGAV NUF2 SHBG
Entrez ID		4363	563
HPRD ID		01153	01910
Ensembl ID		ENSG00000103222	ENSG00000160862
Uniprot IDs		P33527	P25311
PDB IDs		2CBZ	1T7V 1T7W 1T7X 1T7Y 1T7Z 1T80 1ZAG 3ES6
Enriched GO Terms of Interacting Partners?		Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Centriole Replication Negative Regulation Of Centrosome Duplication Positive Regulation Of Immune Response Negative Regulation Of Cell Proliferation CENP-A Containing Nucleosome Assembly Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Ribosome Assembly Regulation Of Immune Response Sensory Perception Of Bitter Taste Tumor Necrosis Factor-mediated Signaling Pathway Histone Exchange Positive Regulation Of Immune System Process DNA Replication-independent Nucleosome Assembly Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Cellular Response To DsRNA Regulation Of Interferon-beta Production Regulation Of Centrosome Duplication Negative Regulation Of Type I Interferon Production Regulation Of Centrosome Cycle Centromere Complex Assembly Centrosome Cycle Protein Transmembrane Transport Retina Homeostasis Negative Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway Sensory Perception Of Taste MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response ATP-dependent Chromatin Remodeling Regulation Of Immune System Process Cell Aging Response To DsRNA Positive Regulation Of Translation Regulation Of Defense Response To Virus Toll-like Receptor 4 Signaling Pathway Protein Transport Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Apoptotic Process Establishment Of Protein Localization Regulation Of Cell Proliferation Regulation Of T Cell Mediated Cytotoxicity Regulation Of Cell Death	Negative Regulation Of Entry Of Bacterium Into Host Cell Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis Primary Spermatocyte Growth Cell Growth Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Receptor Biosynthetic Process Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Lipoprotein Metabolic Process Positive Regulation Of Osteoblast Proliferation Regulation Of Apoptotic Cell Clearance Regulation Of Lipoprotein Metabolic Process Growth Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process ERK1 And ERK2 Cascade Cobalamin Metabolic Process Negative Regulation Of Lipid Storage Negative Chemotaxis Heterotypic Cell-cell Adhesion Negative Regulation Of Lipid Transport Regulation Of Osteoblast Proliferation Apoptotic Cell Clearance Leukotriene Metabolic Process Endodermal Cell Differentiation Viral Entry Into Host Cell Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Phagocytosis Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Endoderm Formation Regulation Of Lipid Storage
Tagcloud ?		abcb1 abcb5 abcb8 abcc3 abcc5 abcg2 bcrp canine cassette cytostatic demographics dogs doxorubicin efflux glucocorticoids hypercalcaemia lymphoma lymphomas mrp1 multicentric multidrug protocol quantified staging substage transporter tumour typically	aggressively aggressiveness analyzing australian biomarkers died dying epidemiological estimate estimates gleason ihc localized minority mrr mrrs muc1 nkx3 nonlethal panel poisson probabilities prostate pten referents retrieved sampling score semiquantitative
Tagcloud (Difference) ?		abcb1 abcb5 abcb8 abcc3 abcc5 abcg2 bcrp canine cassette cytostatic demographics dogs doxorubicin efflux glucocorticoids hypercalcaemia lymphoma lymphomas mrp1 multicentric multidrug protocol quantified staging substage transporter tumour typically	aggressively aggressiveness analyzing australian biomarkers died dying epidemiological estimate estimates gleason ihc localized minority mrr mrrs muc1 nkx3 nonlethal panel poisson probabilities prostate pten referents retrieved sampling score semiquantitative
Tagcloud (Intersection) ?