FILNC1 and WARS1

Number of citations of the paper that reports this interaction (PubMedID 28978906)
44

Data Source:
BioGRID (unspecified method)

		FILNC1	WARS1
Description		FOXO induced long non-coding RNA 1	tryptophanyl-tRNA synthetase 1
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function		Nucleotide Binding Aminoacyl-tRNA Ligase Activity Tryptophan-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Kinase Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process		Angiogenesis Translation TRNA Aminoacylation For Protein Translation Tryptophanyl-tRNA Aminoacylation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Protein-containing Complex Assembly Regulation Of Angiogenesis
Pathways			Cytosolic tRNA aminoacylation
Drugs			Tryptophan Tryptophanyl-5'amp Tryptophanamide
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		88 interacting genes: AAAS ABCC1 ACTN1 ACTR2 AHSA1 AIMP2 AKAP8 ALDH1B1 AP1B1 AP3D1 ARAP1 ARF6 ATP2A2 CAND1 CCT6B CLPX CNDP2 COPG1 DDX24 DNM1 DNM1L DPM1 DYNC1H1 EEF1D EEF2 ERLIN1 GALK1 GMPS GSTO1 HDLBP HNRNPA0 HNRNPD HSPA1A IDH1 KTN1 LAMC1 LAS1L MAP1S MCM3 MRPL4 MSH2 MTHFD1L MYL12A NIBAN2 NKRF NOP56 NPEPPSP1 NSF NUP153 OASL OGT PCAT1 PDCD4 PES1 PFAS PLS3 PPME1 PSMC2 PSMC4 PSMD14 PSMD5 PURA QNG1 RIGI RO60 RPL13A RPS5 RPSA SART1 STT3B STXBP2 TAGLN2 TIMM50 TMEM126A TMX3 TRIP13 TTLL12 TTN U2AF1 UBA52 UBE4A VPS35 WARS1 XPO1 XPOT XRCC6 YWHAB ZCCHC8	15 interacting genes: APP CDK2AP2 CEBPA DCAF13 DNMT3B DSCAM EEF1A1 FILNC1 LCOR LIG4 LINC01554 MDH2 OGT TERF1 UBC
Entrez ID		100132735	7453
HPRD ID			01845
Ensembl ID		ENSG00000231426	ENSG00000140105
Uniprot IDs			A0A024R6K8 P23381
PDB IDs			1O5T 1R6T 1R6U 1ULH 2AKE 2AZX 2DR2 2QUH 2QUI 2QUJ 2QUK 5UJI 5UJJ
Enriched GO Terms of Interacting Partners?		RNA Binding Cytosol ATP Hydrolysis Activity Nucleotide Binding Cadherin Binding Ribonucleoprotein Complex Ficolin-1-rich Granule Lumen ATP Binding Extracellular Exosome Proteasome Accessory Complex Cytoplasm Translation Intracellular Transport Proteasome Regulatory Particle, Base Subcomplex Secretory Granule Lumen Nucleoplasm Actin Filament Binding Macromolecule Metabolic Process Nucleolus Mitochondrion-derived Vesicle Intracellular Protein Transport Organelle Localization Cellular Localization Establishment Of Localization In Cell Proteasome Complex Nucleobase-containing Compound Metabolic Process Actin Filament Network Formation ATP-dependent Protein Disaggregase Activity Proteasome-activating Activity LncRNA Binding Membrane Coat Ribosome Cytoplasmic Translation Establishment Of Organelle Localization Double-stranded DNA Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Protein Localization ATP-dependent Protein Folding Chaperone Cellular Component Assembly Regulation Of Cytoplasmic Translation	Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Central Nervous System Development Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Neuron Recognition Nucleus Cellular Response To Metal Ion Response To Lithium Ion Cellular Response To Lithium Ion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Establishment Of Integrated Proviral Latency L-malate Dehydrogenase (NADP+) Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nuclear Estrogen Receptor Binding Regulation Of Glycolytic Process Negative Regulation Of Transcription By RNA Polymerase II Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Carbohydrate Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Chromatin DNA Binding CHOP-C/EBP Complex Stem Cell Proliferation Response To Vitamin B2 C/EBP Complex DNA-methyltransferase Activity DNA (cytosine-5-)-methyltransferase Activity Post-embryonic Retina Morphogenesis In Camera-type Eye
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