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ABCC1
Gene Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Image
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Extracellular Vesicular Exosome
Molecular Function
Transporter Activity
ATP Binding
ATPase Activity
ATPase Activity, Coupled To Transmembrane Movement Of Substances
Biological Process
Leukotriene Metabolic Process
Vitamin Metabolic Process
Water-soluble Vitamin Metabolic Process
Transport
Cobalamin Metabolic Process
Arachidonic Acid Metabolic Process
Response To Drug
Small Molecule Metabolic Process
Transmembrane Transport
Pathways
Metabolism of vitamins and cofactors
Defective CD320 causes methylmalonic aciduria
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
ABC-family proteins mediated transport
Metabolism of lipids and lipoproteins
Defective BTD causes biotidinase deficiency
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Arachidonic acid metabolism
Defective AMN causes hereditary megaloblastic anemia 1
Defects in cobalamin (B12) metabolism
Defective GIF causes intrinsic factor deficiency
Defective HLCS causes multiple carboxylase deficiency
Defective MMAB causes methylmalonic aciduria type cblB
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
Defective MMAA causes methylmalonic aciduria type cblA
Defective CUBN causes hereditary megaloblastic anemia 1
Cobalamin (Cbl, vitamin B12) transport and metabolism
Defective MUT causes methylmalonic aciduria mut type
Metabolism of water-soluble vitamins and cofactors
Defects in biotin (Btn) metabolism
Defective TCN2 causes hereditary megaloblastic anemia
Defects in vitamin and cofactor metabolism
Drugs
Sulfinpyrazone
Diseases
GWAS
Protein-protein Interactions
3 interactors:
AZGP1
NPM1
TRAF3
Entrez ID
4363
HPRD ID
01153
Ensembl ID
ENSG00000103222
Uniprot IDs
P33527
PDB IDs
2CBZ
Enriched GO Terms of Interacting Partners
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Regulation Of Endoribonuclease Activity
Regulation Of EIF2 Alpha Phosphorylation By DsRNA
Regulation Of Ribonuclease Activity
Regulation Of Endodeoxyribonuclease Activity
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation
Toll Signaling Pathway
Regulation Of Centriole Replication
Negative Regulation Of Centrosome Duplication
Positive Regulation Of Immune Response
Negative Regulation Of Cell Proliferation
CENP-A Containing Nucleosome Assembly
Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste
Ribosome Assembly
Regulation Of Immune Response
Sensory Perception Of Bitter Taste
Tumor Necrosis Factor-mediated Signaling Pathway
Histone Exchange
Positive Regulation Of Immune System Process
DNA Replication-independent Nucleosome Assembly
Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste
Cellular Response To DsRNA
Regulation Of Interferon-beta Production
Regulation Of Centrosome Duplication
Negative Regulation Of Type I Interferon Production
Regulation Of Centrosome Cycle
Centromere Complex Assembly
Centrosome Cycle
Protein Transmembrane Transport
Retina Homeostasis
Negative Regulation Of NF-kappaB Transcription Factor Activity
TRIF-dependent Toll-like Receptor Signaling Pathway
Sensory Perception Of Taste
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Immune Response
ATP-dependent Chromatin Remodeling
Regulation Of Immune System Process
Cell Aging
Response To DsRNA
Positive Regulation Of Translation
Regulation Of Defense Response To Virus
Toll-like Receptor 4 Signaling Pathway
Protein Transport
Positive Regulation Of T Cell Mediated Cytotoxicity
Regulation Of Apoptotic Process
Establishment Of Protein Localization
Regulation Of Cell Proliferation
Regulation Of T Cell Mediated Cytotoxicity
Regulation Of Cell Death
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abcb1
abcb5
abcb8
abcc3
abcc5
abcg2
bcrp
canine
cassette
cytostatic
demographics
dogs
doxorubicin
efflux
glucocorticoids
hypercalcaemia
lymphoma
lymphomas
mrp1
multicentric
multidrug
protocol
quantified
staging
substage
transporter
tumour
typically