ABCC1 and TRAF3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ABCC1	TRAF3
Gene Name		ATP-binding cassette, sub-family C (CFTR/MRP), member 1	TNF receptor-associated factor 3
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Vesicular Exosome	Mitochondrion Endosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Transporter Activity ATP Binding ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances	Ubiquitin-protein Transferase Activity Signal Transducer Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ligase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding
	Biological Process	Leukotriene Metabolic Process Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Transport Cobalamin Metabolic Process Arachidonic Acid Metabolic Process Response To Drug Small Molecule Metabolic Process Transmembrane Transport	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Signal Transduction Toll Signaling Pathway Protein Ubiquitination Regulation Of Proteolysis Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Innate Immune Response Regulation Of Defense Response To Virus
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF ABC-family proteins mediated transport Metabolism of lipids and lipoproteins Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Arachidonic acid metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defects in cobalamin (B12) metabolism Defective GIF causes intrinsic factor deficiency Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Synthesis of Leukotrienes (LT) and Eoxins (EX) Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in vitamin and cofactor metabolism	Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway Toll-Like Receptors Cascades Negative regulators of RIG-I/MDA5 signaling TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade MyD88-independent cascade Innate Immune System Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs		Sulfinpyrazone
Diseases
GWAS			Brain imaging in schizophrenia (interaction) ( 19023125)
Protein-Protein Interactions		3 interactors: AZGP1 NPM1 TRAF3	55 interactors: ABCC1 ALPL APOBEC3C AZI2 BIRC3 CASP3 CD27 CD40 DAXX EDA2R EDAR EWSR1 FAS GRIN1 GRIN2D IL15 IRF1 LTBR MAP2K1 MAP3K14 NGFRAP1 NUP62 OTUD5 PDLIM7 RIPK1 RRAS2 SAR1A SRC TANK TBK1 TDP2 TICAM1 TNFRSF11A TNFRSF12A TNFRSF13C TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TRADD TRAF2 TRAF3IP1 TRAF3IP2 TRAF3IP3 TRAF5 TRIM37 UBE2I USP7 ZBP1 ZMYND11
Entrez ID		4363	7187
HPRD ID		01153	03539
Ensembl ID		ENSG00000103222	ENSG00000131323
Uniprot IDs		P33527	A6NHG8 Q13114
PDB IDs		2CBZ	1FLK 1FLL 1KZZ 1L0A 1RF3 1ZMS 2ECY 2GKW
Enriched GO Terms of Interacting Partners?		Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Ribonuclease Activity Regulation Of Endodeoxyribonuclease Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Centriole Replication Negative Regulation Of Centrosome Duplication Positive Regulation Of Immune Response Negative Regulation Of Cell Proliferation CENP-A Containing Nucleosome Assembly Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Ribosome Assembly Regulation Of Immune Response Sensory Perception Of Bitter Taste Tumor Necrosis Factor-mediated Signaling Pathway Histone Exchange Positive Regulation Of Immune System Process DNA Replication-independent Nucleosome Assembly Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Cellular Response To DsRNA Regulation Of Interferon-beta Production Regulation Of Centrosome Duplication Negative Regulation Of Type I Interferon Production Regulation Of Centrosome Cycle Centromere Complex Assembly Centrosome Cycle Protein Transmembrane Transport Retina Homeostasis Negative Regulation Of NF-kappaB Transcription Factor Activity TRIF-dependent Toll-like Receptor Signaling Pathway Sensory Perception Of Taste MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response ATP-dependent Chromatin Remodeling Regulation Of Immune System Process Cell Aging Response To DsRNA Positive Regulation Of Translation Regulation Of Defense Response To Virus Toll-like Receptor 4 Signaling Pathway Protein Transport Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Apoptotic Process Establishment Of Protein Localization Regulation Of Cell Proliferation Regulation Of T Cell Mediated Cytotoxicity Regulation Of Cell Death	Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Tumor Necrosis Factor Cellular Response To Tumor Necrosis Factor Regulation Of Cytokine Production Signal Transduction Positive Regulation Of Protein Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Cellular Response To Stimulus Extrinsic Apoptotic Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Regulation Of Signaling Response To Stimulus Immune Response Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cytokine Production Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Process Regulation Of Apoptotic Process Response To Cytokine Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Lymphocyte Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Cytokine Stimulus Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cell Death
Tagcloud ?		abcb1 abcb5 abcb8 abcc3 abcc5 abcg2 bcrp canine cassette cytostatic demographics dogs doxorubicin efflux glucocorticoids hypercalcaemia lymphoma lymphomas mrp1 multicentric multidrug protocol quantified staging substage transporter tumour typically	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf5 traf6 transduction
Tagcloud (Difference) ?		abcb1 abcb5 abcb8 abcc3 abcc5 abcg2 bcrp canine cassette cytostatic demographics dogs doxorubicin efflux glucocorticoids hypercalcaemia lymphoma lymphomas mrp1 multicentric multidrug protocol quantified staging substage transporter tumour typically	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf5 traf6 transduction
Tagcloud (Intersection) ?