MPP3 and EZR

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MPP3	EZR
Gene Name		membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	ezrin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Ruffle Uropod Extracellular Space Nucleolus Cytosol Actin Filament Plasma Membrane Microvillus Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium T-tubule Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Ciliary Basal Body Cell Body Microspike Membrane Raft Apical Part Of Cell Cell Tip Extracellular Vesicular Exosome Cell Periphery Astrocyte Projection Schwann Cell Microvillus
	Molecular Function	Guanylate Kinase Activity PDZ Domain Binding	Protein Binding Protein Domain Specific Binding Poly(A) RNA Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Signal Transduction Nucleotide Phosphorylation	Cytoskeletal Anchoring At Plasma Membrane Leukocyte Cell-cell Adhesion Axon Guidance Regulation Of Cell Shape Positive Regulation Of Gene Expression Membrane To Membrane Docking Microvillus Assembly Receptor Internalization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Actin Filament Bundle Assembly Establishment Of Endothelial Barrier
Pathways			Axon guidance L1CAM interactions Netrin-1 signaling Recycling pathway of L1
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: APP ARL2BP CADM1 CCDC137 CRABP1 ERBB2IP EZR FAM171B GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A MCM2 MDH1 NOA1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZPR1	49 interactors: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CFTR CLIC5 CTNNB1 DLG1 EGFR FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MPP3 MSN NF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 S100P SCYL3 SDC2 SELL SELP SLC9A3R1 SLC9A3R2 SPN TBC1D10A TMEM8B TSC1 VCAM1 WFDC1 WWOX
Entrez ID		4356	7430
HPRD ID		03069	00475
Ensembl ID		ENSG00000161647	ENSG00000092820
Uniprot IDs		Q13368	P15311
PDB IDs			1NI2
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Binding Cell Growth Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Protein Binding Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Binding Regulation Of Protein Homodimerization Activity Growth Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle MRNA Metabolic Process Positive Regulation Of Binding Cellular Response To Epidermal Growth Factor Stimulus Multicellular Organismal Development Asymmetric Protein Localization System Development Establishment Or Maintenance Of Apical/basal Cell Polarity RNA Processing DNA Strand Elongation Involved In DNA Replication Positive Regulation Of Signal Transduction Response To Epidermal Growth Factor DNA Strand Elongation Organelle Organization Exocytosis RNA Splicing Signaling Cellular Protein Localization G1/S Transition Of Mitotic Cell Cycle Cell Communication Nervous System Development Receptor Internalization Cellular Component Assembly Positive Regulation Of Interleukin-15 Production Nuclear Speck Organization Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Neurotrophin Production Dermatan Sulfate Catabolic Process Positive Regulation Of Nonmotile Primary Cilium Assembly TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Pre-mRNA Catabolic Process DNA Endoreduplication Signal Transduction Positive Regulation Of Innate Immune Response Protein Localization Regulation Of Phosphorus Metabolic Process	Cell Adhesion Single Organismal Cell-cell Adhesion Movement Of Cell Or Subcellular Component Locomotion Cell Migration Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Organic Substance Leukocyte Migration Regulation Of Signaling Leukocyte Cell-cell Adhesion Organ Development Membrane To Membrane Docking Positive Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Cell Differentiation Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Phosphorylation Cell Activation Apoptotic Process Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Immune Response System Development Response To Growth Factor Cell Death Anatomical Structure Development Death Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Multicellular Organismal Development Blood Coagulation Developmental Process Hemostasis Defense Response Response To Radiation Positive Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Stimulus Cell Development Regulation Of Body Fluid Levels
Tagcloud ?		17q12 abundant backcross brca1 carboxy cdnas clustering conservation cytoskeleton dlgh3 guanylate homologue homologues interspecific kb maguks mapped murine originally pdz presumably proximity sh3 skeletal subclass testis transcript translated virtue	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?		17q12 abundant backcross brca1 carboxy cdnas clustering conservation cytoskeleton dlgh3 guanylate homologue homologues interspecific kb maguks mapped murine originally pdz presumably proximity sh3 skeletal subclass testis transcript translated virtue	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?