EZR and SPN

Number of citations of the paper that reports this interaction (PubMedID 9616160)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		EZR	SPN
Description		ezrin	sialophorin
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Ruffle Immunological Synapse Uropod Extracellular Space Cytoplasm Endosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Microvillus Brush Border Adherens Junction Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Protein-containing Complex Ciliary Basal Body Cell Projection Plasma Membrane Raft Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery	Uropod Basement Membrane Extracellular Space Nucleus Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane PML Body Cell Projection Extracellular Exosome
	Molecular Function	RNA Binding Actin Binding Protein Binding Microtubule Binding Cytoskeletal Protein Binding Protein Domain Specific Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding S100 Protein Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding Protein Kinase A Binding ATPase Binding Disordered Domain Specific Binding	Transmembrane Signaling Receptor Activity Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intestinal D-glucose Absorption Sphingosine-1-phosphate Receptor Signaling Pathway Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Positive Regulation Of Gene Expression Protein Kinase A Signaling Gland Morphogenesis Membrane To Membrane Docking Microvillus Assembly Actin Cytoskeleton Organization Astral Microtubule Organization Protein-containing Complex Localization Receptor Internalization Regulation Of Microvillus Length Negative Regulation Of Interleukin-2 Production Regulation Of Actin Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Multicellular Organism Growth Cortical Microtubule Organization Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Filopodium Assembly Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Establishment Of Centrosome Localization Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Protein Localization To Cell Cortex Postsynaptic Actin Cytoskeleton Organization Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Organelle Assembly Terminal Web Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of P38MAPK Cascade Positive Regulation Of Early Endosome To Late Endosome Transport	Response To Protozoan Negative Regulation Of Type IV Hypersensitivity T-helper 1 Cell Lineage Commitment Chemotaxis Immune Response Cellular Defense Response Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Costimulation Positive Regulation Of Tumor Necrosis Factor Production T Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Negative Thymic T Cell Selection Regulation Of Defense Response To Virus Regulation Of Immune Response Regulation Of T Cell Activation Negative Regulation Of T Cell Activation Leukocyte Tethering Or Rolling Apoptotic Signaling Pathway Regulation Of T Cell Migration Positive Regulation Of T Cell Migration
Pathways		Netrin-1 signaling Recycling pathway of L1 Recycling pathway of L1 Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Cell surface interactions at the vascular wall Basigin interactions
Drugs
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Hair color ( 29662168) Refractive error ( 32231278)
Interacting Genes		57 interacting genes: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CEBPA CFTR CLIC5 CTNNB1 DLG1 EGFR ERBB3 FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MME MPP3 MSN NF2 NHERF1 NHERF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 RSPH1 S100P SCYL3 SDC2 SELL SELP SLC26A4-AS1 SPN SUMO2 TBC1D10A TMEM8B TSC1 USP1 VCAM1 VPS11 WFDC1 WWOX	18 interacting genes: ARL13B CLCA4 CTNNB1 CTSA CXCL16 CYBC1 DAXX ERGIC3 EZR FYN ICAM1 LGALS1 LMNA MSN PLP2 SGTA SIGLEC1 UBQLN2
Entrez ID		7430	6693
HPRD ID		00475	06770
Ensembl ID		ENSG00000092820	ENSG00000197471
Uniprot IDs		P15311	P16150
PDB IDs		1NI2 4RM8 4RM9 4RMA 7T1K 7T1L
Enriched GO Terms of Interacting Partners?		Plasma Membrane Cell Adhesion Cell-cell Adhesion Focal Adhesion Leukocyte Cell-cell Adhesion Cell Migration Cell Motility Microvillus Regulation Of Intracellular Signal Transduction Lamellipodium Extracellular Exosome Membrane Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Adhesion Membrane To Membrane Docking Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Tethering Or Rolling Regulation Of Multicellular Organismal Process Response To Growth Factor Positive Regulation Of Transport Regulation Of Cell-cell Adhesion Filopodium Regulation Of Developmental Process Regulation Of Cell Migration Cell Projection Regulation Of Signal Transduction Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Localization Regulation Of Apoptotic Process Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Membrane Docking Cell Surface Cellular Developmental Process Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Regulation Of Programmed Cell Death Apical Plasma Membrane Integrin Binding Developmental Process Regulation Of Locomotion Cell-substrate Adhesion T Cell Activation Cell-matrix Adhesion Ruffle	Membrane To Membrane Docking Disordered Domain Specific Binding Microvillus Membrane Cell Periphery Regulation Of Protein Catabolic Process Cell-cell Adhesion Establishment Of Endothelial Barrier T Cell Migration Endothelial Cell Development Lymphocyte Migration Leukocyte Cell-cell Adhesion Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Lymphocyte Activation Leukocyte Migration Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Protein Catabolic Process Uropod Apical Part Of Cell Membrane Docking Layer Formation In Cerebral Cortex Postsynaptic Density, Intracellular Component Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of ERAD Pathway Cell Adhesion Mononuclear Cell Migration Membrane Cell Migration Regulation Of Protein Localization T Cell Activation Leukocyte Activation Establishment Of Apical/basal Cell Polarity Negative Regulation Of Protein Catabolic Process Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of ERAD Pathway Epithelial Cell Development Plasma Membrane Regulation Of Cell Shape Positive Regulation Of Intracellular Transport Gland Morphogenesis Establishment Of Epithelial Cell Polarity Cell Activation Cell Motility Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?