MPP3 and IDUA

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		MPP3	IDUA
Gene Name		membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	iduronidase, alpha-L-
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane	Coated Vesicle Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Guanylate Kinase Activity PDZ Domain Binding	L-iduronidase Activity Receptor Binding
	Biological Process	Signal Transduction Nucleotide Phosphorylation	Cell Morphogenesis Carbohydrate Metabolic Process Disaccharide Metabolic Process Glycosaminoglycan Catabolic Process Lysosome Organization Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Catabolic Process Limb Morphogenesis Small Molecule Metabolic Process Skeletal System Morphogenesis Chemical Homeostasis
Pathways			MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism CS/DS degradation Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS			Bone mineral density ( 22504420)
Protein-Protein Interactions		33 interactors: APP ARL2BP CADM1 CCDC137 CRABP1 ERBB2IP EZR FAM171B GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A MCM2 MDH1 NOA1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZPR1	1 interactors: MPP3
Entrez ID		4356	3425
HPRD ID		03069	02016
Ensembl ID		ENSG00000161647	ENSG00000127415
Uniprot IDs		Q13368	B3KWK6 P35475
PDB IDs			1Y24 3W81 3W82 4KGJ 4KGL 4KH2 4MJ2 4MJ4
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Binding Cell Growth Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Protein Binding Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Binding Regulation Of Protein Homodimerization Activity Growth Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Cycle MRNA Metabolic Process Positive Regulation Of Binding Cellular Response To Epidermal Growth Factor Stimulus Multicellular Organismal Development Asymmetric Protein Localization System Development Establishment Or Maintenance Of Apical/basal Cell Polarity RNA Processing DNA Strand Elongation Involved In DNA Replication Positive Regulation Of Signal Transduction Response To Epidermal Growth Factor DNA Strand Elongation Organelle Organization Exocytosis RNA Splicing Signaling Cellular Protein Localization G1/S Transition Of Mitotic Cell Cycle Cell Communication Nervous System Development Receptor Internalization Cellular Component Assembly Positive Regulation Of Interleukin-15 Production Nuclear Speck Organization Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Positive Regulation Of Neurotrophin Production Dermatan Sulfate Catabolic Process Positive Regulation Of Nonmotile Primary Cilium Assembly TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Pre-mRNA Catabolic Process DNA Endoreduplication Signal Transduction Positive Regulation Of Innate Immune Response Protein Localization Regulation Of Phosphorus Metabolic Process
Tagcloud ?		17q12 abundant backcross brca1 carboxy cdnas clustering conservation cytoskeleton dlgh3 guanylate homologue homologues interspecific kb maguks mapped murine originally pdz presumably proximity sh3 skeletal subclass testis transcript translated virtue	attain avoiding beauty c57bl correcting cumulatively cyclophosphamide decay deliver drive hydrodynamically hyperactive iduronidase immunocompetent immunosuppression infuse integrating minimize mucopolysaccharidosis plasmids sb sb100x shutdown sleeping transgene transposase transposition transposon vis
Tagcloud (Difference) ?		17q12 abundant backcross brca1 carboxy cdnas clustering conservation cytoskeleton dlgh3 guanylate homologue homologues interspecific kb maguks mapped murine originally pdz presumably proximity sh3 skeletal subclass testis transcript translated virtue	attain avoiding beauty c57bl correcting cumulatively cyclophosphamide decay deliver drive hydrodynamically hyperactive iduronidase immunocompetent immunosuppression infuse integrating minimize mucopolysaccharidosis plasmids sb sb100x shutdown sleeping transgene transposase transposition transposon vis
Tagcloud (Intersection) ?