EZR and ADORA2B

Number of citations of the paper that reports this interaction (PMID 12080047)
25

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		EZR	ADORA2B
Gene Name		ezrin	adenosine A2b receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Uropod Extracellular Space Nucleolus Cytosol Actin Filament Plasma Membrane Microvillus Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium T-tubule Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Ciliary Basal Body Cell Body Microspike Membrane Raft Apical Part Of Cell Cell Tip Extracellular Vesicular Exosome Cell Periphery Astrocyte Projection Schwann Cell Microvillus	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding Poly(A) RNA Binding Cell Adhesion Molecule Binding Actin Filament Binding	G-protein Coupled Adenosine Receptor Activity
	Biological Process	Cytoskeletal Anchoring At Plasma Membrane Leukocyte Cell-cell Adhesion Axon Guidance Regulation Of Cell Shape Positive Regulation Of Gene Expression Membrane To Membrane Docking Microvillus Assembly Receptor Internalization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Actin Filament Bundle Assembly Establishment Of Endothelial Barrier	Activation Of MAPK Activity Adenosine Receptor Signaling Pathway Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Cellular Defense Response G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity JNK Cascade Excretion Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Extracellular Stimulus Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Mast Cell Degranulation Relaxation Of Vascular Smooth Muscle
Pathways		Axon guidance L1CAM interactions Netrin-1 signaling Recycling pathway of L1	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Nucleotide-like (purinergic) receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Adenosine P1 receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Theophylline Adenosine Enprofylline Defibrotide
Diseases
GWAS			Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Protein-Protein Interactions		49 interactors: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CFTR CLIC5 CTNNB1 DLG1 EGFR FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MPP3 MSN NF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 S100P SCYL3 SDC2 SELL SELP SLC9A3R1 SLC9A3R2 SPN TBC1D10A TMEM8B TSC1 VCAM1 WFDC1 WWOX	7 interactors: ADA DCC EZR NTN1 SLC9A3R2 TPD52L2 ZNF267
Entrez ID		7430	136
HPRD ID		00475	15971
Ensembl ID		ENSG00000092820	ENSG00000170425
Uniprot IDs		P15311	P29275
PDB IDs		1NI2
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Movement Of Cell Or Subcellular Component Locomotion Cell Migration Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Organic Substance Leukocyte Migration Regulation Of Signaling Leukocyte Cell-cell Adhesion Organ Development Membrane To Membrane Docking Positive Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Cell Differentiation Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Phosphorylation Cell Activation Apoptotic Process Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Immune Response System Development Response To Growth Factor Cell Death Anatomical Structure Development Death Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Multicellular Organismal Development Blood Coagulation Developmental Process Hemostasis Defense Response Response To Radiation Positive Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Stimulus Cell Development Regulation Of Body Fluid Levels	Anterior/posterior Axon Guidance Axon Guidance Negative Regulation Of Axonogenesis Regulation Of Cell Morphogenesis Negative Regulation Of Developmental Growth Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Deoxyadenosine Catabolic Process Xanthine Biosynthetic Process Single Organismal Cell-cell Adhesion Axonogenesis Negative Regulation Of Cell Morphogenesis Involved In Differentiation Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Neuron Projection Development Chemotaxis Negative Regulation Of Mucus Secretion Purine Deoxyribonucleoside Metabolic Process Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Neuron Projection Morphogenesis Regulation Of Cell Size Negative Regulation Of Cell Projection Organization Netrin-activated Signaling Pathway Spinal Cord Ventral Commissure Morphogenesis Germinal Center B Cell Differentiation Adenosine Catabolic Process DATP Catabolic Process Deoxyribonucleoside Catabolic Process Inosine Biosynthetic Process Hypoxanthine Salvage Negative Regulation Of Cell Growth Cell Morphogenesis Involved In Differentiation Regulation Of Axonogenesis Response To External Stimulus Neuron Migration Dorsal/ventral Axon Guidance Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Negative Regulation Of Mature B Cell Apoptotic Process Neuron Projection Development Negative Regulation Of Neuron Differentiation Membrane To Membrane Docking Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Germinal Center Formation Positive Regulation Of Neuron Projection Development Negative Regulation Of Collateral Sprouting Neuron Development
Tagcloud ?		actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf	acvrl1 agtrap angpt2 angptl4 apln cbf csrp2 ednra egfl7 ero1l flowmetry flt1 hi id1 immunolabeled iodoantipyrine kdr microvasculature mins nitroarginine normoxia nos3 nudt6 perimed pf5001 prrx1 serpine1 stereological
Tagcloud (Difference) ?		actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf	acvrl1 agtrap angpt2 angptl4 apln cbf csrp2 ednra egfl7 ero1l flowmetry flt1 hi id1 immunolabeled iodoantipyrine kdr microvasculature mins nitroarginine normoxia nos3 nudt6 perimed pf5001 prrx1 serpine1 stereological
Tagcloud (Intersection) ?