EZR and VCAM1

Number of citations of the paper that reports this interaction (PMID 12082081)
93

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		EZR	VCAM1
Gene Name		ezrin	vascular cell adhesion molecule 1
Image
Gene Ontology Annotations	Cellular Component	Ruffle Uropod Extracellular Space Nucleolus Cytosol Actin Filament Plasma Membrane Microvillus Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium T-tubule Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Ciliary Basal Body Cell Body Microspike Membrane Raft Apical Part Of Cell Cell Tip Extracellular Vesicular Exosome Cell Periphery Astrocyte Projection Schwann Cell Microvillus	Podosome Extracellular Space Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Filopodium Sarcolemma Apical Part Of Cell Extracellular Vesicular Exosome Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding Poly(A) RNA Binding Cell Adhesion Molecule Binding Actin Filament Binding	Integrin Binding Primary Amine Oxidase Activity Cell Adhesion Molecule Binding
	Biological Process	Cytoskeletal Anchoring At Plasma Membrane Leukocyte Cell-cell Adhesion Axon Guidance Regulation Of Cell Shape Positive Regulation Of Gene Expression Membrane To Membrane Docking Microvillus Assembly Receptor Internalization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Actin Filament Bundle Assembly Establishment Of Endothelial Barrier	Response To Hypoxia Acute Inflammatory Response Chronic Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Heart Development Aging Response To Nutrient Amine Metabolic Process Response To Zinc Ion Response To Ionizing Radiation Viral Process Cytokine-mediated Signaling Pathway Membrane To Membrane Docking B Cell Differentiation Extracellular Matrix Organization Response To Lipopolysaccharide Response To Nicotine Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of T Cell Proliferation Response To Ethanol Regulation Of Immune Response Leukocyte Tethering Or Rolling Oxidation-reduction Process Cell Chemotaxis Interferon-gamma-mediated Signaling Pathway Chorio-allantoic Fusion Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor
Pathways		Axon guidance L1CAM interactions Netrin-1 signaling Recycling pathway of L1	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs			Carvedilol
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		49 interactors: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CFTR CLIC5 CTNNB1 DLG1 EGFR FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MPP3 MSN NF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 S100P SCYL3 SDC2 SELL SELP SLC9A3R1 SLC9A3R2 SPN TBC1D10A TMEM8B TSC1 VCAM1 WFDC1 WWOX	10 interactors: CCL17 CCL22 CTSG ELANE EZR IL13 ITGAD ITGB1 ITGB7 MSN
Entrez ID		7430	7412
HPRD ID		00475	01888
Ensembl ID		ENSG00000092820	ENSG00000162692
Uniprot IDs		P15311	P19320
PDB IDs		1NI2	1IJ9 1VCA 1VSC
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Movement Of Cell Or Subcellular Component Locomotion Cell Migration Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Organic Substance Leukocyte Migration Regulation Of Signaling Leukocyte Cell-cell Adhesion Organ Development Membrane To Membrane Docking Positive Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Cell Differentiation Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Phosphorylation Cell Activation Apoptotic Process Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Immune Response System Development Response To Growth Factor Cell Death Anatomical Structure Development Death Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Multicellular Organismal Development Blood Coagulation Developmental Process Hemostasis Defense Response Response To Radiation Positive Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Stimulus Cell Development Regulation Of Body Fluid Levels	Immune System Process Movement Of Cell Or Subcellular Component Response To External Stimulus Heterotypic Cell-cell Adhesion Leukocyte Cell-cell Adhesion Locomotion Response To Other Organism Response To Biotic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Cell Migration Cell Motility Single Organismal Cell-cell Adhesion Membrane To Membrane Docking Leukocyte Migration Killing By Host Of Symbiont Cells Immune Response Regulation Of Immune System Process Defense Response Integrin-mediated Signaling Pathway Leukocyte Tethering Or Rolling Inflammatory Response Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Cell Adhesion Establishment Of Endothelial Barrier Cellular Extravasation Chemotaxis Interaction With Symbiont Leukocyte Mediated Cytotoxicity Response To Fungus Viral Entry Into Host Cell Entry Into Host Cell Response To Virus Endothelial Cell Development Response To Lipopolysaccharide Positive Regulation Of Smooth Muscle Cell Proliferation Response To Lipid Response To Molecule Of Bacterial Origin Regulation Of Immune Response Cellular Response To Mechanical Stimulus Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Endothelial Cell Differentiation Response To Stimulus
Tagcloud ?		actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf	accessory cd4 delayed determinant dr foreign genital hpvs hypersensitivity icam1 immuno keratinocytes langerhans lymphocytes monitored mount nonregressing papillomavirus predominated rank regressing regression responsiveness selectin stroma sum wart warts wilcoxon
Tagcloud (Difference) ?		actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf	accessory cd4 delayed determinant dr foreign genital hpvs hypersensitivity icam1 immuno keratinocytes langerhans lymphocytes monitored mount nonregressing papillomavirus predominated rank regressing regression responsiveness selectin stroma sum wart warts wilcoxon
Tagcloud (Intersection) ?