MPP3 and SCN2A

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		MPP3	SCN2A
Name		MAGUK p55 scaffold protein 3	sodium voltage-gated channel alpha subunit 2
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Adherens Junction Membrane Apical Plasma Membrane Anchoring Junction	Voltage-gated Sodium Channel Complex Plasma Membrane Membrane Axon Node Of Ranvier Monoatomic Ion Channel Complex
	Molecular Function	Protein Binding PDZ Domain Binding	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Calmodulin Binding
	Biological Process	None	Action Potential Monoatomic Ion Transport Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Transmembrane Transport Cellular Response To Hypoxia Cardiac Muscle Cell Action Potential Involved In Contraction
Pathways		None	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs		None	Tramadol Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Chloroprocaine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Metergoline Bioallethrin Amylmetacresol Fish oil
Diseases		None	Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		HDL cholesterol levels ( 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 24097068 )	Adult body size ( 32376654 ) Age at first birth ( 34211149 ) Age at first sexual intercourse ( 34211149 ) Bipolar disorder ( 34002096 33263727 31043756 ) Diastolic blood pressure ( 30224653 ) Epilepsy ( 30531953 ) Factor VII activity ( 30642921 ) Febrile seizures ( 25344690 ) Febrile seizures (MMR vaccine-related) ( 25344690 ) Febrile seizures (MMR vaccine-unrelated) ( 25344690 ) Focal epilepsy ( 30531953 ) Generalized epilepsy ( 30531953 ) Periodontitis (DPAL) ( 24024966 ) Refractive error ( 32231278 ) Trunk fat mass ( 28552196 ) Urinary sodium excretion ( 31409800 )
Novel Interactors		1 novel interactors: TBK1	5 novel interactors: B4GAT1 BAZ2B GALNT13 PKP4 PLA2R1
Interacting Genes		37 interacting genes: APP ARL2BP BTBD1 CADM1 CCDC137 CRABP1 ERBIN EZR FAM171B FBXO7 GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A MCM2 MDH1 NOA1 PKNOX1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZNF655 ZPR1	5 interacting genes: ANK3 ARHGEF10L MPP3 RNF130 SCN4B
Entrez ID		4356	6326
HPRD ID		03069	03133
Ensembl ID		ENSG00000161647	ENSG00000136531
Uniprot IDs		D3DX46 Q13368	Q99250
PDB IDs		Not available	2KAV 4JPZ 4RLY 6BUT 6J8E
GO Terms Enriched among Interactors		None	Sodium Channel Regulator Activity Organelle Neuronal Action Potential Positive Regulation Of Sodium Ion Transport Intercalated Disc Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transport Maintenance Of Protein Location In Plasma Membrane Positive Regulation Of Podocyte Apoptotic Process Negative Regulation Of Arachidonate Secretion Positive Regulation Of Cell Communication By Electrical Coupling Action Potential Negative Regulation Of Icosanoid Secretion Oxidative Stress-induced Premature Senescence Transmembrane Transporter Binding Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Spectrin-associated Cytoskeleton Channel Activator Activity Regulation Of Membrane Depolarization During Action Potential Negative Regulation Of Voltage-gated Potassium Channel Activity Cellular Response To Magnesium Ion Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Monoatomic Ion Transport Adherens Junction Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Protein O-linked Glycosylation Protein Glycosylation Glycosyltransferase Activity Poly-N-acetyllactosamine Metabolic Process Glycosylation N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Poly-N-acetyllactosamine Biosynthetic Process Macromolecule Glycosylation Carbohydrate Binding Regulation Of Arachidonate Secretion Stress-induced Premature Senescence Phospholipase A2 Inhibitor Activity Positive Regulation Of Arachidonate Secretion Negative Regulation Of Fatty Acid Transport Cellular Response To Sterol Depletion SREBP Signaling Pathway