MPP3 and HSH2D

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MPP3	HSH2D
Description		MAGUK p55 scaffold protein 3	hematopoietic SH2 domain containing
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Adherens Junction Membrane Apical Plasma Membrane Anchoring Junction	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding PDZ Domain Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process		Negative Regulation Of B Cell Apoptotic Process Signal Transduction T Cell Activation Negative Regulation Of Mitochondrial Depolarization
Pathways
Drugs
Diseases
GWAS		HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		37 interacting genes: APP ARL2BP BTBD1 CADM1 CCDC137 CRABP1 ERBIN EZR FAM171B FBXO7 GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A MCM2 MDH1 NOA1 PKNOX1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZNF655 ZPR1	21 interacting genes: AR CNMD CRK EGFR ERBB2 ERBB3 ERBB4 FES GAB1 KIT LDHAL6B MET MPP3 OLIG1 PIK3R3 PINK1 PLPP6 RBP7 TNK2 TSC1 TSG101
Entrez ID		4356	84941
HPRD ID		03069	12219
Ensembl ID		ENSG00000161647	ENSG00000196684
Uniprot IDs		D3DX46 Q13368	Q96JZ2
PDB IDs			2CS0
Enriched GO Terms of Interacting Partners?			Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Cellular Developmental Process Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Ubiquitin Protein Ligase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Motility ERBB3:ERBB2 Complex Positive Regulation Of Phosphate Metabolic Process Animal Organ Development Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Epithelial Cell Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Protein Modification Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Phosphorylation Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Population Proliferation Regulation Of Phosphorylation Regulation Of Cell Migration Positive Regulation Of Phosphorylation ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Cell Population Proliferation
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