MPP3 and RRAGC

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		MPP3	RRAGC
Name		MAGUK p55 scaffold protein 3	Ras related GTP binding C
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Adherens Junction Membrane Apical Plasma Membrane Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane Gtr1-Gtr2 GTPase Complex FNIP-folliculin RagC/D GAP
	Molecular Function	Protein Binding PDZ Domain Binding	Nucleotide Binding Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-membrane Adaptor Activity Protein Heterodimerization Activity GTPase Binding Molecular Adaptor Activity Enzyme-substrate Adaptor Activity
	Biological Process	None	Autophagosome Assembly Cytoplasmic Translation DNA-templated Transcription Apoptotic Process Lysosome Organization Small GTPase-mediated Signal Transduction Intracellular Protein Localization RNA Splicing Cellular Response To Starvation Negative Regulation Of Autophagy SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Cellular Response To Nutrient Levels Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation TORC1 Signaling Response To Amino Acid Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Protein Localization To Membrane Negative Regulation Of Protein Localization To Nucleus Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		None	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
GWAS		HDL cholesterol levels ( 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 24097068 )	Beard thickness ( 26926045 )
Novel Interactors		1 novel interactors: TBK1	None recorded
Interacting Genes		37 interacting genes: APP ARL2BP BTBD1 CADM1 CCDC137 CRABP1 ERBIN EZR FAM171B FBXO7 GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A MCM2 MDH1 NOA1 PKNOX1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZNF655 ZPR1	7 interacting genes: ATXN1L DEPDC5 MPP3 NOL8 RRAGA RRAGB WNT2
Entrez ID		4356	64121
HPRD ID		03069	12198
Ensembl ID		ENSG00000161647	ENSG00000116954
Uniprot IDs		D3DX46 Q13368	B4DQ03 B4DQG4 Q9HB90
PDB IDs		Not available	3LLU 6CES 6EHR 6NZD 6S6A 6S6D 6SB0 6SB2 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
GO Terms Enriched among Interactors		None	Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling GATOR1 Complex Gtr1-Gtr2 GTPase Complex Positive Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of TOR Signaling Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome TORC1 Signaling Lysosomal Membrane Regulation Of Autophagy Guanyl Ribonucleotide Binding Cellular Response To Amino Acid Stimulus TOR Signaling Protein Localization To Vacuole Response To Nutrient Levels Lysosome Regulation Of Translational Initiation Negative Regulation Of Autophagy Response To Amino Acid Cytoplasmic Translation Lung Induction Protein Localization To Organelle POZ Domain Binding Positive Regulation Of Translation Cell Proliferation In Midbrain Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Branching Involved In Lung Morphogenesis Negative Regulation Of Translation Cellular Response To Methionine Atrial Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Response To Methionine Intracellular Protein Localization Iris Morphogenesis FNIP-folliculin RagC/D GAP Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Hematopoietic Stem Cell Proliferation Mammary Gland Epithelium Development Protein Localization To Nucleolus Wnt Signalosome Midbrain Dopaminergic Neuron Differentiation Cellular Response To Leucine Starvation GTPase Activity