EZR and SDC2

Number of citations of the paper that reports this interaction (PMID 10704377)
19

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		EZR	SDC2
Gene Name		ezrin	syndecan 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Uropod Extracellular Space Nucleolus Cytosol Actin Filament Plasma Membrane Microvillus Focal Adhesion Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Filopodium T-tubule Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Ciliary Basal Body Cell Body Microspike Membrane Raft Apical Part Of Cell Cell Tip Extracellular Vesicular Exosome Cell Periphery Astrocyte Projection Schwann Cell Microvillus	Golgi Lumen Plasma Membrane Integral Component Of Membrane Neuronal Cell Body Lysosomal Lumen Synapse
	Molecular Function	Protein Binding Protein Domain Specific Binding Poly(A) RNA Binding Cell Adhesion Molecule Binding Actin Filament Binding	Protein Binding PDZ Domain Binding
	Biological Process	Cytoskeletal Anchoring At Plasma Membrane Leukocyte Cell-cell Adhesion Axon Guidance Regulation Of Cell Shape Positive Regulation Of Gene Expression Membrane To Membrane Docking Microvillus Assembly Receptor Internalization Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Actin Filament Bundle Assembly Establishment Of Endothelial Barrier	Retinoid Metabolic Process Response To Hypoxia Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Axon Guidance Phototransduction, Visible Light Biological_process Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Response To Caffeine Wound Healing Small Molecule Metabolic Process Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis
Pathways		Axon guidance L1CAM interactions Netrin-1 signaling Recycling pathway of L1	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Axon guidance Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism EPHB-mediated forward signaling Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D EPH-Ephrin signaling A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Diseases associated with visual transduction Defective EXT1 causes exostoses 1, TRPS2 and CHDS Syndecan interactions MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		49 interactors: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CFTR CLIC5 CTNNB1 DLG1 EGFR FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MPP3 MSN NF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 S100P SCYL3 SDC2 SELL SELP SLC9A3R1 SLC9A3R2 SPN TBC1D10A TMEM8B TSC1 VCAM1 WFDC1 WWOX	26 interactors: BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF KAL1 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4
Entrez ID		7430	6383
HPRD ID		00475	00803
Ensembl ID		ENSG00000092820	ENSG00000169439
Uniprot IDs		P15311	E9PBI9 P34741
PDB IDs		1NI2
Enriched GO Terms of Interacting Partners?		Cell Adhesion Single Organismal Cell-cell Adhesion Movement Of Cell Or Subcellular Component Locomotion Cell Migration Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Motility Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Response To Organic Substance Leukocyte Migration Regulation Of Signaling Leukocyte Cell-cell Adhesion Organ Development Membrane To Membrane Docking Positive Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Cell-cell Adhesion Cell Differentiation Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Immune Response Regulation Of Phosphorylation Cell Activation Apoptotic Process Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Immune Response System Development Response To Growth Factor Cell Death Anatomical Structure Development Death Response To External Stimulus Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Multicellular Organismal Development Blood Coagulation Developmental Process Hemostasis Defense Response Response To Radiation Positive Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Stimulus Cell Development Regulation Of Body Fluid Levels	Regulation Of Body Fluid Levels Platelet Activation Wound Healing Response To Wounding Blood Coagulation Hemostasis Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Regulation Of Epithelial Cell Proliferation Cell Activation Regulation Of Angiogenesis Regulation Of Cell Migration Multicellular Organismal Development Regulation Of Epithelial Cell Migration Response To External Stimulus Regulation Of Cell Motility Regulation Of Cell Proliferation Response To Stimulus Regulation Of Locomotion Regulation Of Cellular Component Movement Locomotion Positive Regulation Of Signal Transduction System Development Developmental Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endothelial Cell Migration Anatomical Structure Development Chemotaxis Movement Of Cell Or Subcellular Component Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Regulation Of Wound Healing Regulation Of Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Stress Positive Regulation Of Endothelial Cell Migration Regulation Of Cellular Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cell Migration Cell Development Histone H3-T6 Phosphorylation
Tagcloud ?		actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf	affymetrix akt2 aroused bioinformatics ccng2 ccnu cdkn2c chemosensitivity ep300 excavate gbm id2 igfbp3 map2k2 mdm4 pdgfd perfected picked plethora prkca raf1 rbl1 rigorous semustine socs2 stmn1 tcf7l1 tubb unsatisfactory
Tagcloud (Difference) ?		actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 ntn1 polyp signatures slc9a2 vwf	affymetrix akt2 aroused bioinformatics ccng2 ccnu cdkn2c chemosensitivity ep300 excavate gbm id2 igfbp3 map2k2 mdm4 pdgfd perfected picked plethora prkca raf1 rbl1 rigorous semustine socs2 stmn1 tcf7l1 tubb unsatisfactory
Tagcloud (Intersection) ?