EZR and SDC2

Number of citations of the paper that reports this interaction (PubMedID 10704377)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		EZR	SDC2
Description		ezrin	syndecan 2
Image
GO Annotations	Cellular Component	Fibrillar Center Ruffle Immunological Synapse Uropod Extracellular Space Cytoplasm Endosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Microvillus Brush Border Adherens Junction Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Protein-containing Complex Ciliary Basal Body Cell Projection Plasma Membrane Raft Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Membrane Extracellular Matrix Lysosomal Lumen
	Molecular Function	RNA Binding Actin Binding Protein Binding Microtubule Binding Cytoskeletal Protein Binding Protein Domain Specific Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding S100 Protein Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding Protein Kinase A Binding ATPase Binding Disordered Domain Specific Binding	Protein Binding PDZ Domain Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intestinal D-glucose Absorption Sphingosine-1-phosphate Receptor Signaling Pathway Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Positive Regulation Of Gene Expression Protein Kinase A Signaling Gland Morphogenesis Membrane To Membrane Docking Microvillus Assembly Actin Cytoskeleton Organization Astral Microtubule Organization Protein-containing Complex Localization Receptor Internalization Regulation Of Microvillus Length Negative Regulation Of Interleukin-2 Production Regulation Of Actin Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Multicellular Organism Growth Cortical Microtubule Organization Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Filopodium Assembly Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Establishment Of Centrosome Localization Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Protein Localization To Cell Cortex Postsynaptic Actin Cytoskeleton Organization Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Organelle Assembly Terminal Web Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of P38MAPK Cascade Positive Regulation Of Early Endosome To Late Endosome Transport	Nervous System Development Cell Migration Cell Differentiation Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis
Pathways		Netrin-1 signaling Recycling pathway of L1 Recycling pathway of L1 Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions
Drugs			Sargramostim
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Hair color ( 29662168) Refractive error ( 32231278)	Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)
Interacting Genes		57 interacting genes: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CEBPA CFTR CLIC5 CTNNB1 DLG1 EGFR ERBB3 FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MME MPP3 MSN NF2 NHERF1 NHERF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 RSPH1 S100P SCYL3 SDC2 SELL SELP SLC26A4-AS1 SPN SUMO2 TBC1D10A TMEM8B TSC1 USP1 VCAM1 VPS11 WFDC1 WWOX	29 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4 UBC
Entrez ID		7430	6383
HPRD ID		00475	00803
Ensembl ID		ENSG00000092820	ENSG00000169439
Uniprot IDs		P15311	E9PBI9 P34741
PDB IDs		1NI2 4RM8 4RM9 4RMA 7T1K 7T1L	6ITH
Enriched GO Terms of Interacting Partners?		Plasma Membrane Cell Adhesion Cell-cell Adhesion Focal Adhesion Leukocyte Cell-cell Adhesion Cell Migration Cell Motility Microvillus Regulation Of Intracellular Signal Transduction Lamellipodium Extracellular Exosome Membrane Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Adhesion Membrane To Membrane Docking Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Tethering Or Rolling Regulation Of Multicellular Organismal Process Response To Growth Factor Positive Regulation Of Transport Regulation Of Cell-cell Adhesion Filopodium Regulation Of Developmental Process Regulation Of Cell Migration Cell Projection Regulation Of Signal Transduction Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Localization Regulation Of Apoptotic Process Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Membrane Docking Cell Surface Cellular Developmental Process Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Regulation Of Programmed Cell Death Apical Plasma Membrane Integrin Binding Developmental Process Regulation Of Locomotion Cell-substrate Adhesion T Cell Activation Cell-matrix Adhesion Ruffle	Extracellular Space Regulation Of Multicellular Organismal Process Platelet Alpha Granule Lumen Extracellular Region Regulation Of Developmental Process Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Regulation Of MAPK Cascade Regulation Of Wound Healing Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial Cell Proliferation Regulation Of Multicellular Organismal Development Heparin Binding Signaling Receptor Binding Positive Regulation Of Gene Expression Extracellular Matrix Regulation Of Response To Wounding Basement Membrane Signal Transduction Regulation Of Endothelial Cell Migration Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Vasculature Development Response To Wounding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Migration Anatomical Structure Morphogenesis Plasma Membrane Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macrophage Differentiation Regulation Of Vesicle-mediated Transport Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Signal Transduction
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