CD99 and UBE2H

Number of citations of the paper that reports this interaction (PubMedID 15388255)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CD99	UBE2H
Description		CD99 molecule (Xg blood group)	ubiquitin conjugating enzyme E2 H
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Focal Adhesion Membrane	Nucleus Cytosol
	Molecular Function	Protein Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Cell Adhesion Homotypic Cell-cell Adhesion T Cell Extravasation Positive Regulation Of Neutrophil Extravasation	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: ANXA2 ENTR1 FTH1 KPNB1 MTNR1A MTNR1B PPIA SGTA TRIP13 UBE2H UBQLN1 UBQLN4	71 interacting genes: BRAP CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GID4 GOLGA2 H2AC18 H2AC20 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MDM2 MKRN3 NEURL1 NEURL2 NHLRC1 POLL POLM PRKN PSME3 RAG1 RBX1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 STUB1 TLE5 TRAIP TRIM13 TRIM17 TRIM2 TRIM23 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 TRIM72 UBASH3B UBOX5 UBR2 UBR3
Entrez ID		4267	7328
HPRD ID		02434	03052
Ensembl ID		ENSG00000002586	ENSG00000186591
Uniprot IDs		A0A096LP69 P14209	A0A3B3IU20 A4D1L5 P62256
PDB IDs		7SFX	2Z5D 8PJN
Enriched GO Terms of Interacting Partners?		Melatonin Receptor Activity Autophagosome Regulation Of Protein Catabolic Process Regulation Of Proteolysis Ficolin-1-rich Granule Lumen Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Cellular Response To Stress Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Identical Protein Binding G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport AnxA2-p11 Complex PCSK9-AnxA2 Complex Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Intracellular Cholesterol Transport Ferritin Complex Ferroxidase Activity Iron Ion Sequestering Activity Protein-containing Complex Cell Adhesion Molecule Production Protein Peptidyl-prolyl Isomerization Negative Regulation Of Protein K48-linked Ubiquitination TRC Complex Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Proteolysis Involved In Protein Catabolic Process Meiotic Recombination Checkpoint Signaling Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Positive Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Transport Positive Regulation Of Plasma Membrane Repair Positive Regulation Of Intracellular Lipid Transport Regulation Of Protein Metabolic Process Mitotic Chromosome Movement Towards Spindle Pole Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep BAT3 Complex Binding Positive Regulation Of Proteasomal Protein Catabolic Process	Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Protein Metabolic Process Protein Polyubiquitination Metal Ion Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Macromolecule Catabolic Process Proteolysis Protein Catabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Protein Monoubiquitination Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination Autophagy Positive Regulation Of Catabolic Process Cytoplasm Endoplasmic Reticulum Mannose Trimming Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Protein Alpha-1,2-demannosylation Suppression Of Viral Release By Host Immune System Process Protein Deglycosylation Aggresome Assembly Innate Immune Response Positive Regulation Of Protein Catabolic Process ERAD Pathway Endoplasmic Reticulum Quality Control Compartment Cellular Response To Stress Protein K6-linked Ubiquitination Ubiquitin Binding Inclusion Body Assembly Response To Endoplasmic Reticulum Stress Positive Regulation Of Autophagy Aggresome Defense Response To Symbiont Defense Response To Other Organism
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