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MAP3K5 and EIF2AK2
Number of citations of the paper that reports this interaction (PubMedID
12473108
)
0
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vitro, in vivo)
MAP3K5
EIF2AK2
Description
mitogen-activated protein kinase kinase kinase 5
eukaryotic translation initiation factor 2 alpha kinase 2
Image
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum
Cytosol
External Side Of Plasma Membrane
Protein-containing Complex
Protein Kinase Complex
IRE1-TRAF2-ASK1 Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Ribosome
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Kinase Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Serine Kinase Activity
Nucleotide Binding
RNA Binding
Double-stranded RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Eukaryotic Translation Initiation Factor 2alpha Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Phosphatase Regulator Activity
Identical Protein Binding
Protein Serine Kinase Activity
Biological Process
MAPK Cascade
Immune System Process
Response To Ischemia
Apoptotic Process
JNK Cascade
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Cellular Response To Amino Acid Starvation
Response To Endoplasmic Reticulum Stress
Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
P38MAPK Cascade
Positive Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Positive Regulation Of MAPK Cascade
Innate Immune Response
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of JNK Cascade
Neuron Apoptotic Process
Stress-activated MAPK Cascade
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Hydrogen Peroxide
Cellular Response To Tumor Necrosis Factor
Endothelial Cell Apoptotic Process
Cellular Senescence
Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Positive Regulation Of P38MAPK Cascade
Cellular Response To Reactive Nitrogen Species
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Cytokine Production
Immune System Process
Translation
Translational Initiation
Regulation Of Translational Initiation
Protein Phosphorylation
Negative Regulation Of Cell Population Proliferation
Response To Virus
Negative Regulation Of Translation
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Chemokine Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Osteoblast Proliferation
Cellular Response To Amino Acid Starvation
Response To Interferon-alpha
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Antiviral Innate Immune Response
Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Regulation Of Hematopoietic Progenitor Cell Differentiation
Regulation Of Hematopoietic Stem Cell Proliferation
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Oxidative Stress Induced Senescence
Oxidative Stress Induced Senescence
ISG15 antiviral mechanism
Inhibition of PKR
SUMOylation of immune response proteins
Interferon alpha/beta signaling
Evasion by RSV of host interferon responses
PKR-mediated signaling
Drugs
Indomethacin
H-89
Fostamatinib
Diseases
GWAS
Eosinophil count (
32888494
)
HDL cholesterol (
30275531
)
HDL cholesterol levels (
32203549
)
Immature fraction of reticulocytes (
32888494
)
Monocyte count (
32888494
)
Neutrophil count (
32888494
)
White blood cell count (
32888494
)
Glucose homeostasis traits (
25524916
)
Platelet count (
32888494
)
Interacting Genes
69 interacting genes:
AKT1
ARRB2
AURKA
BIRC2
CCND2
CDC25A
CDC25C
CDK4
CDK6
CDKN1A
CDKN2A
CIB1
CREBBP
DAB2IP
DAXX
DMD
DUSP19
EIF2AK2
EP300
ERN1
FGFR4
FZR1
GADD45B
GEMIN5
GLIS2
GLRX
GSTM1
HSPA1A
IGF1R
JAK2
MAP2K4
MAP2K6
MAP2K7
MAP3K2
MAP3K3
MAP3K6
MAP3K7
MAPK8IP3
MBP
NEDD4
NEDD4L
NF2
PDCD6
PPP3R1
PPP5C
PRMT1
PTPN11
QARS1
RAF1
SFN
SIAH1
STK11
TEAD2
TERT
TNFAIP3
TNFAIP8L1
TNNT2
TPD52L1
TRAF2
TRAF5
TRAF6
TULP3
TXN
UBE2I
USP9X
YWHAE
YWHAH
YWHAQ
YWHAZ
131 interacting genes:
ADARB1
CAPRIN1
CASP3
CASP7
CASP8
CDC42
CHUK
DHX58
DICER1
DNAJC3
EDC4
EIF2A
EIF2S1
EIF6
ELF2
FTSJ3
H2AC20
H2AC4
HSP90AA1
HSPA1A
IKBKB
IL7R
ILF2
ILF3
JAK1
LINC00624
MAP2K6
MAP3K5
MAP3K7
MAVS
METAP2
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
NCK1
NEIL3
NFKBIA
NPM1
OGT
PA2G4
PDGFRB
PPP1CA
PPP1CC
PPP2R5A
PRKRA
PRKRIP1
PTGES3
RAC1
RPL18
SPIDR
STAT1
STAT3
STRBP
SUMO1
TAB2
TARBP2
THAP12
TIRAP
TP53
TYK2
UBE2I
ZNF346
Entrez ID
4217
5610
HPRD ID
03904
01468
Ensembl ID
ENSG00000197442
ENSG00000055332
Uniprot IDs
A0A8V8TMH5
Q99683
A0A7P0Z4M0
P19525
Q8IW76
PDB IDs
2CLQ
3VW6
4BF2
4BHN
4BIB
4BIC
4BID
4BIE
5ULM
5UOR
5UOX
5UP3
5V19
5V24
5VIL
5VIO
6E2M
6E2N
6E2O
6EJL
6OYT
6OYW
6VRE
6XIH
7MU6
7MU7
8QGY
1QU6
2A19
2A1A
3UIU
6D3K
6D3L
7OBK
7OBL
8BI7
8I9J
8IZN
Enriched GO Terms of Interacting Partners
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Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Intracellular Signaling Cassette
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of MAPK Cascade
Signal Transduction
Cytosol
Cytoplasm
Positive Regulation Of MAPK Cascade
Cellular Response To Stress
Regulation Of Protein Metabolic Process
MAPK Cascade
Regulation Of Programmed Cell Death
Regulation Of Protein Modification Process
Regulation Of Apoptotic Process
Protein Kinase Binding
Protein Modification Process
Positive Regulation Of Protein Metabolic Process
Transferase Activity
Enzyme Binding
Regulation Of Primary Metabolic Process
Protein Kinase Activity
Positive Regulation Of Macromolecule Metabolic Process
Apoptotic Process
Programmed Cell Death
Cell Death
Positive Regulation Of Metabolic Process
Protein Serine Kinase Activity
Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Population Proliferation
Regulation Of Metabolic Process
Regulation Of JNK Cascade
Kinase Activity
Apoptotic Signaling Pathway
Protein Serine/threonine Kinase Activity
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Catalytic Activity
Identical Protein Binding
Negative Regulation Of Signal Transduction
Regulation Of Cell Cycle
Regulation Of Protein Kinase Activity
Protein Metabolic Process
Regulation Of Innate Immune Response
RISC Complex
MiRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
MRNA 3'-UTR Binding
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Regulation Of Metabolic Process
Negative Regulation Of Translation
Extracellular Vesicle
Regulation Of Translation
Negative Regulation Of Cytokine Production
Negative Regulation Of Cell Migration
Regulation Of Cytokine Production
MRNA Destabilization
Positive Regulation Of MRNA Catabolic Process
Negative Regulation Of Cell Motility
RNA Destabilization
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Locomotion
Regulation Of Angiogenesis
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Angiogenesis
Negative Regulation Of Vasculature Development
Regulation Of Vasculature Development
Negative Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of MRNA Metabolic Process
Regulation Of MRNA Stability
Regulation Of Cell Migration
Regulation Of RNA Stability
Regulation Of Protein Metabolic Process
Negative Regulation Of Signal Transduction
Regulation Of Cell Motility
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Locomotion
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Developmental Process
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Tagcloud (Intersection)
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