MAP3K5 and GLRX

Number of citations of the paper that reports this interaction (PubMedID 12244106)
0

Data Source:
HPRD (in vitro)

		MAP3K5	GLRX
Description		mitogen-activated protein kinase kinase kinase 5	glutaredoxin
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol External Side Of Plasma Membrane Protein-containing Complex Protein Kinase Complex IRE1-TRAF2-ASK1 Complex	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Disulfide Oxidoreductase Activity Glutathione Disulfide Oxidoreductase Activity Sodium Channel Regulator Activity
	Biological Process	MAPK Cascade Immune System Process Response To Ischemia Apoptotic Process JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress P38MAPK Cascade Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Neuron Apoptotic Process Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Endothelial Cell Apoptotic Process Cellular Senescence Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of P38MAPK Cascade Cellular Response To Reactive Nitrogen Species Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Nucleobase-containing Small Molecule Interconversion Positive Regulation Of Membrane Potential
Pathways		Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence	Interconversion of nucleotide di- and triphosphates
Drugs			Glutathione
Diseases
GWAS		Eosinophil count ( 32888494) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)	hemolysis of donated blood (oxidative) ( 34014839) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		69 interacting genes: AKT1 ARRB2 AURKA BIRC2 CCND2 CDC25A CDC25C CDK4 CDK6 CDKN1A CDKN2A CIB1 CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 FGFR4 FZR1 GADD45B GEMIN5 GLIS2 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L NF2 PDCD6 PPP3R1 PPP5C PRMT1 PTPN11 QARS1 RAF1 SFN SIAH1 STK11 TEAD2 TERT TNFAIP3 TNFAIP8L1 TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TULP3 TXN UBE2I USP9X YWHAE YWHAH YWHAQ YWHAZ	8 interacting genes: AQP5 CASP3 GOT2 MAP3K5 MMP23B NFIC PTPN1 TRIM62
Entrez ID		4217	2745
HPRD ID		03904	02707
Ensembl ID		ENSG00000197442	ENSG00000173221
Uniprot IDs		A0A8V8TMH5 Q99683	P35754
PDB IDs		2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE 5ULM 5UOR 5UOX 5UP3 5V19 5V24 5VIL 5VIO 6E2M 6E2N 6E2O 6EJL 6OYT 6OYW 6VRE 6XIH 7MU6 7MU7 8QGY	1B4Q 1JHB 4RQR
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Signal Transduction Cytosol Cytoplasm Positive Regulation Of MAPK Cascade Cellular Response To Stress Regulation Of Protein Metabolic Process MAPK Cascade Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Regulation Of Apoptotic Process Protein Kinase Binding Protein Modification Process Positive Regulation Of Protein Metabolic Process Transferase Activity Enzyme Binding Regulation Of Primary Metabolic Process Protein Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Metabolic Process Protein Serine Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of JNK Cascade Kinase Activity Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Catalytic Activity Identical Protein Binding Negative Regulation Of Signal Transduction Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Protein Metabolic Process Regulation Of Innate Immune Response	Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Reactive Nitrogen Species Cellular Response To Osmotic Stress Cellular Response To Chemical Stress Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Osmotic Stress Odontogenesis Response To Hydrogen Peroxide Phospholipase A2 Activator Activity L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of JNK Cascade Pancreatic Juice Secretion Positive Regulation Of Programmed Cell Death Anterior Neural Tube Closure Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Apoptotic Process Response To Tumor Necrosis Factor Cellular Response To Staurosporine Neuron Apoptotic Process Luteolysis Glial Cell Apoptotic Process Response To Reactive Oxygen Species L-aspartate Catabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Protein Kinase Complex IRE1-TRAF2-ASK1 Complex Regulation Of JNK Cascade Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Insulin Receptor Recycling Positive Regulation Of Antifungal Innate Immune Response Saliva Secretion Response To Anesthetic Intrinsic Apoptotic Signaling Pathway Sorting Endosome Endoplasmic Reticulum Death-inducing Signaling Complex Aspartate Metabolic Process Cellular Response To Stress Oxaloacetate Metabolic Process L-glutamate Catabolic Process Malate-aspartate Shuttle Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of IRE1-mediated Unfolded Protein Response Mitochondrial Crista Positive Regulation Of Pyroptotic Inflammatory Response
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