MAP3K5 and DUSP19

Number of citations of the paper that reports this interaction (PubMedID 11959862)
0

Data Source:
HPRD (in vitro, in vivo)

		MAP3K5	DUSP19
Description		mitogen-activated protein kinase kinase kinase 5	dual specificity phosphatase 19
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol External Side Of Plasma Membrane Protein-containing Complex Protein Kinase Complex IRE1-TRAF2-ASK1 Complex	Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity JUN Kinase Phosphatase Activity Hydrolase Activity Protein Kinase Activator Activity Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	MAPK Cascade Immune System Process Response To Ischemia Apoptotic Process JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress P38MAPK Cascade Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Neuron Apoptotic Process Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Endothelial Cell Apoptotic Process Cellular Senescence Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of P38MAPK Cascade Cellular Response To Reactive Nitrogen Species Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of JNK Cascade Negative Regulation Of JNK Cascade Positive Regulation Of JNK Cascade
Pathways		Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence
Drugs
Diseases
GWAS		Eosinophil count ( 32888494) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		69 interacting genes: AKT1 ARRB2 AURKA BIRC2 CCND2 CDC25A CDC25C CDK4 CDK6 CDKN1A CDKN2A CIB1 CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 FGFR4 FZR1 GADD45B GEMIN5 GLIS2 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L NF2 PDCD6 PPP3R1 PPP5C PRMT1 PTPN11 QARS1 RAF1 SFN SIAH1 STK11 TEAD2 TERT TNFAIP3 TNFAIP8L1 TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TULP3 TXN UBE2I USP9X YWHAE YWHAH YWHAQ YWHAZ	19 interacting genes: ACTB ALK EGFR EPHA2 EPHB6 ERBB2 ERBB3 ERBB4 FLT4 IGF1R INSR KDR LMTK2 MAP2K7 MAP3K5 MAPK9 PTK7 ROR1 ROR2
Entrez ID		4217	142679
HPRD ID		03904	13254
Ensembl ID		ENSG00000197442	ENSG00000162999
Uniprot IDs		A0A8V8TMH5 Q99683	Q8WTR2
PDB IDs		2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE 5ULM 5UOR 5UOX 5UP3 5V19 5V24 5VIL 5VIO 6E2M 6E2N 6E2O 6EJL 6OYT 6OYW 6VRE 6XIH 7MU6 7MU7 8QGY	3S4E 4D3P 4D3Q 4D3R
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Signal Transduction Cytosol Cytoplasm Positive Regulation Of MAPK Cascade Cellular Response To Stress Regulation Of Protein Metabolic Process MAPK Cascade Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Regulation Of Apoptotic Process Protein Kinase Binding Protein Modification Process Positive Regulation Of Protein Metabolic Process Transferase Activity Enzyme Binding Regulation Of Primary Metabolic Process Protein Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Metabolic Process Protein Serine Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of JNK Cascade Kinase Activity Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Catalytic Activity Identical Protein Binding Negative Regulation Of Signal Transduction Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Protein Metabolic Process Regulation Of Innate Immune Response	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Kinase Activity Receptor Complex Nucleotide Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Transferase Activity Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Protein Autophosphorylation Protein Phosphorylation Phosphorylation Positive Regulation Of Signal Transduction Growth Factor Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Coreceptor Activity Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of ERK1 And ERK2 Cascade Signal Transduction Regulation Of Signal Transduction Response To Growth Factor Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Axon Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Positive Regulation Of Phosphate Metabolic Process ERBB3:ERBB2 Complex ERBB Signaling Pathway Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Positive Regulation Of ERK1 And ERK2 Cascade
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