MAP3K5 and FGFR4

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		MAP3K5	FGFR4
Description		mitogen-activated protein kinase kinase kinase 5	fibroblast growth factor receptor 4
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol External Side Of Plasma Membrane Protein-containing Complex Protein Kinase Complex IRE1-TRAF2-ASK1 Complex	Extracellular Region Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction Membrane Transport Vesicle Receptor Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Fibroblast Growth Factor Receptor Activity Protein Binding ATP Binding Heparin Binding Kinase Activity Transferase Activity Fibroblast Growth Factor Binding
	Biological Process	MAPK Cascade Immune System Process Response To Ischemia Apoptotic Process JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress P38MAPK Cascade Positive Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Neuron Apoptotic Process Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Endothelial Cell Apoptotic Process Cellular Senescence Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of P38MAPK Cascade Cellular Response To Reactive Nitrogen Species Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation	Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Lipid Metabolic Process Glucose Homeostasis Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Proteolysis Protein Autophosphorylation Phosphate Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Bile Acid Biosynthetic Process Response To Bile Acid Positive Regulation Of DNA Biosynthetic Process
Pathways		Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence	PI3K Cascade PIP3 activates AKT signaling betaKlotho-mediated ligand binding FGFR4 mutant receptor activation FGFR4 ligand binding and activation Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR4 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR4 signaling Signaling by FGFR4 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Heparin Ponatinib Lenvatinib Infigratinib Erdafitinib Pemigatinib Futibatinib
Diseases
GWAS		Eosinophil count ( 32888494) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)	A body shape index ( 34021172) Activated partial thromboplastin time ( 22703881) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 25282103 31562340 28552196) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hip shape (DXA scan) ( 30320955) Narrowest width of the femoral neck ( 30888730) Nonsyndromic cleft lip ( 31609978) Type 2 diabetes ( 30718926 32499647) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 26785701)
Interacting Genes		69 interacting genes: AKT1 ARRB2 AURKA BIRC2 CCND2 CDC25A CDC25C CDK4 CDK6 CDKN1A CDKN2A CIB1 CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 FGFR4 FZR1 GADD45B GEMIN5 GLIS2 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L NF2 PDCD6 PPP3R1 PPP5C PRMT1 PTPN11 QARS1 RAF1 SFN SIAH1 STK11 TEAD2 TERT TNFAIP3 TNFAIP8L1 TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TULP3 TXN UBE2I USP9X YWHAE YWHAH YWHAQ YWHAZ	82 interacting genes: ABCB5 AKT1 ANGPTL4 ARAF ARNT BECN1 BLID CASC3 CBLC CCND2 CCNE1 CD44 CDH2 CDK4 CDK6 CDKN2A CDKN2B CDKN2C DIRAS3 EPHA4 EPSTI1 ERBB2 ERRFI1 FGF1 FGF17 FGF18 FGF19 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FZR1 GLCE GLIS2 GRM1 HGF HIF1A IGF1R KDELR2 LATS2 LRATD2 MAP2K5 MAP2K6 MAP3K5 MAPK14 MDM4 MET MSH2 MTA3 MYC NF2 NSD3 OSGIN1 PDLIM2 PLCG1 PPP3CA PSMC3IP PTPN11 PTPN12 PTPN6 PTPRR RAF1 RASL10B RASSF1 RNF20 ROS1 SCGB3A1 SNCA STAT1 STAT3 STK11 TEAD2 TERT THRSP TP53 TSC1 TTYH2 WIF1
Entrez ID		4217	2264
HPRD ID		03904	00625
Ensembl ID		ENSG00000197442	ENSG00000160867
Uniprot IDs		A0A8V8TMH5 Q99683	B4DVP5 J3KPQ0 P22455
PDB IDs		2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE 5ULM 5UOR 5UOX 5UP3 5V19 5V24 5VIL 5VIO 6E2M 6E2N 6E2O 6EJL 6OYT 6OYW 6VRE 6XIH 7MU6 7MU7 8QGY	4QQ5 4QQC 4QQJ 4QQT 4QRC 4R6V 4TYE 4TYG 4TYI 4TYJ 4UXQ 4XCU 5JKG 5NUD 5NWZ 5XFF 5XFJ 6IUO 6IUP 6J6Y 6JPE 6JPJ 6NVG 6NVH 6NVI 6NVJ 6NVK 6V9C 6YI8 7DTZ 7F3M 7N1J 7TYD 7V29 7VJL 7WCT 7WCW 7WCX 7YBO 7YBP 7YBX 7YC1 7YC3 7YSW 8KH6 8KH7 8KH8 8KH9 8W5C 8XLQ
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Signal Transduction Cytosol Cytoplasm Positive Regulation Of MAPK Cascade Cellular Response To Stress Regulation Of Protein Metabolic Process MAPK Cascade Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Regulation Of Apoptotic Process Protein Kinase Binding Protein Modification Process Positive Regulation Of Protein Metabolic Process Transferase Activity Enzyme Binding Regulation Of Primary Metabolic Process Protein Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Positive Regulation Of Metabolic Process Protein Serine Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of JNK Cascade Kinase Activity Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Catalytic Activity Identical Protein Binding Negative Regulation Of Signal Transduction Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Protein Metabolic Process Regulation Of Innate Immune Response	Regulation Of Cell Population Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Epithelial Cell Proliferation Cell Differentiation Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Cellular Developmental Process Cell Population Proliferation Regulation Of Cell Cycle Regulation Of Locomotion Neurogenesis Intracellular Signal Transduction Negative Regulation Of Signaling Regulation Of Cell Motility Negative Regulation Of Cell Communication Growth Factor Activity Negative Regulation Of Signal Transduction Regulation Of Cell Migration Regulation Of Programmed Cell Death Fibroblast Growth Factor Receptor Binding Intracellular Signaling Cassette Animal Organ Development Regulation Of Apoptotic Process Developmental Process Regulation Of Developmental Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Positive Regulation Of Epithelial Cell Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle Phase Transition Protein Kinase Binding Epithelial Cell Proliferation Regulation Of Cell Differentiation Regulation Of ERK1 And ERK2 Cascade MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process
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