MAP3K5 and TPD52L1

Number of citations of the paper that reports this interaction (PMID 14761963)
3

Data Source:
HPRD (in vivo)

		MAP3K5	TPD52L1
Gene Name		mitogen-activated protein kinase kinase kinase 5	tumor protein D52-like 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Protein Kinase Complex	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Kinase Binding Protein Phosphatase Binding Protein Homodimerization Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Response To Ischemia Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process JNK Cascade Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Viral Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Neuron Death Cellular Response To Reactive Nitrogen Species	G2/M Transition Of Mitotic Cell Cycle Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS
Protein-Protein Interactions		50 interactors: AKT1 AKT2 ARRB1 ARRB2 CDC25A CDKN1A CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 GADD45B GEMIN5 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L PDCD6 PPP3R1 PPP5C PTPN11 QARS RAF1 SFN TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TXN USP9X YWHAE YWHAH YWHAQ YWHAZ	13 interactors: ABL2 EIF3J GPR135 HDAC1 MAL2 MAP3K5 PAK6 TPD52 TPD52L2 TPD52L3 YAE1D1 YWHAB YWHAZ
Entrez ID		4217	7164
HPRD ID		03904	07236
Ensembl ID		ENSG00000197442	ENSG00000111907
Uniprot IDs		Q99683	E9PPQ1 F6V707 J3KNE7 Q16890
PDB IDs		2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Apoptotic Process Positive Regulation Of Transferase Activity Programmed Cell Death Positive Regulation Of Protein Modification Process Regulation Of Stress-activated MAPK Cascade Cell Death Death Regulation Of MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Response To Stress Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Regulation Of Apoptotic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Metabolic Process Cellular Response To Stimulus Response To Stimulus Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Programmed Cell Death Signal Transduction Signaling Positive Regulation Of Cell Death	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Apoptotic Process Signal Transduction By Phosphorylation Regulation Of Cell Death Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Activation Of MAPKK Activity Apoptotic Process Phosphorylation Programmed Cell Death Cell Death Death Regulation Of Mitochondrion Organization Positive Regulation Of MAPK Cascade Leukocyte Activation Immune System Process Regulation Of Cellular Process Positive Regulation Of Signal Transduction Immune Response Defense Response Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Golgi Reassembly Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Cell Death Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Dephosphorylation Histamine Secretion By Mast Cell Signaling Cell Communication Establishment Of Golgi Localization Positive Regulation Of Transport Positive Regulation Of Apoptotic Signaling Pathway Bergmann Glial Cell Differentiation Golgi Inheritance Regulation Of Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Localization Phosphate-containing Compound Metabolic Process Neurotrophin Signaling Pathway
Tagcloud ?		199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4	abcf2 adprtl1 amy2b arhgap4 atp6ap1 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 ngfrap1 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tra1 trf4 tuba4
Tagcloud (Difference) ?		199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4	abcf2 adprtl1 amy2b arhgap4 atp6ap1 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 ngfrap1 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tra1 trf4 tuba4
Tagcloud (Intersection) ?