MAP3K5 and NEDD4L

Number of citations of the paper that reports this interaction (PMID 19953087)
25

Data Source:
BioGRID (enzymatic study)

		MAP3K5	NEDD4L
Gene Name		mitogen-activated protein kinase kinase kinase 5	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Protein Kinase Complex	Intracellular Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Kinase Binding Protein Phosphatase Binding Protein Homodimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding Potassium Channel Regulator Activity Ligase Activity Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Sodium Channel Inhibitor Activity Ion Channel Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Response To Ischemia Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process JNK Cascade Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Viral Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Neuron Death Cellular Response To Reactive Nitrogen Species	Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of Membrane Depolarization Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Monoubiquitination Sodium Ion Transport Cellular Sodium Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Excretion Response To Salt Stress Response To Metal Ion Gene Expression Positive Regulation Of Sodium Ion Transport Viral Process Protein Ubiquitination Viral Life Cycle Water Homeostasis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Protein Catabolic Process Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Protein Catabolic Process Positive Regulation Of Endocytosis Transmembrane Transport Regulation Of Membrane Repolarization Protein K48-linked Ubiquitination Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Positive Regulation Of Cation Channel Activity Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Oxidative Stress Induced Senescence Cellular Senescence	Loss of Function of TGFBR2 in Cancer Antigen processing: Ubiquitination & Proteasome degradation HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV Life Cycle Budding and maturation of HIV virion Ion channel transport Generic Transcription Pathway Stimuli-sensing channels Class I MHC mediated antigen processing & presentation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Late Phase of HIV Life Cycle Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Insomnia (caffeine-induced) ( 22754043) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Response to amphetamines ( 22952603)
Protein-Protein Interactions		50 interactors: AKT1 AKT2 ARRB1 ARRB2 CDC25A CDKN1A CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 GADD45B GEMIN5 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L PDCD6 PPP3R1 PPP5C PTPN11 QARS RAF1 SFN TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TXN USP9X YWHAE YWHAH YWHAQ YWHAZ	126 interactors: AATF ABL1 ABL2 ACVR1B ACY3 ADAP2 AICDA AKT3 APEX2 ARHGDIA AURKC BBX BMPR1A BRAF C7orf50 CACNB1 CAMK1D CDC34 CDK3 CDK5 CLIC2 CUEDC1 CYBRD1 CYP26B1 DAPK3 DAZAP2 DDX54 DECR2 DMTN DYRK3 EFEMP2 FGF12 FKBP3 GORAB H1F0 HAX1 HGS IFRD2 IKBKB KCNAB1 KCNAB2 KCNAB3 KCNB1 KIF3B KIFC3 LAPTM5 MAGEB1 MAP2 MAP3K2 MAP3K3 MAP3K5 MAPKAPK3 MARK2 MERTK MINK1 MOB3A MRPL19 NDFIP2 NHP2 NR3C1 NSRP1 NTRK1 NUDT16L1 PBX1 PRKX PRR16 PRRG1 PSMD4 RANBP10 RASL10B RASL11B RNF11 RNF7 ROBO3 RPL30 RPS6KB2 SCAMP3 SCD SCN5A SCNN1A SCNN1B SCNN1G SENP2 SERPINF1 SGK1 SGK2 SIVA1 SLC7A7 SMAD2 SMAD3 SMAD7 SNCA SPAG8 SRMS STAC STK40 TAF1B TARBP2 TBC1D7 TCEAL2 TGFB1I1 TMA16 TMEM55A TRIM41 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 UBE2N VDAC2 WIBG WNK1 WNK4 YWHAG YWHAZ YY1 ZADH2 ZAK ZC3HAV1L ZDHHC3
Entrez ID		4217	23327
HPRD ID		03904	05903
Ensembl ID		ENSG00000197442	ENSG00000049759
Uniprot IDs		Q99683	B7Z2P9 B7Z6K0 F5H602 Q96PU5
PDB IDs		2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE	2LAJ 2LB2 2LTY 2NSQ 2ONI 3JVZ 3JW0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Apoptotic Process Positive Regulation Of Transferase Activity Programmed Cell Death Positive Regulation Of Protein Modification Process Regulation Of Stress-activated MAPK Cascade Cell Death Death Regulation Of MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Response To Stress Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Regulation Of Apoptotic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Metabolic Process Cellular Response To Stimulus Response To Stimulus Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Programmed Cell Death Signal Transduction Signaling Positive Regulation Of Cell Death	Cellular Protein Modification Process Protein Phosphorylation Intracellular Signal Transduction Response To Stimulus Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Signaling Regulation Of Signal Transduction Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Protein Polyubiquitination Response To Organic Substance Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Signal Transduction Response To Growth Factor Cellular Response To Organic Substance Protein K48-linked Ubiquitination Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Protein Phosphorylation Protein Autophosphorylation Phosphate-containing Compound Metabolic Process Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Transport Cellular Response To Growth Factor Stimulus Cellular Metabolic Process Immune System Process Protein Ubiquitination Regulation Of Cellular Process Positive Regulation Of Protein Ubiquitination Cell Death Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Death Regulation Of Cellular Component Movement
Tagcloud ?		199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4	2cl antihypertensive cotransporter defective demonstrating emerging enac exchanger highlight hypertension interactor interesting liddle ligase makes na ncc nephron nhe3 nkcc2 originally progress salt sensitive thiazide transporters ubiquitin ubiquitylates
Tagcloud (Difference) ?		199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4	2cl antihypertensive cotransporter defective demonstrating emerging enac exchanger highlight hypertension interactor interesting liddle ligase makes na ncc nephron nhe3 nkcc2 originally progress salt sensitive thiazide transporters ubiquitin ubiquitylates
Tagcloud (Intersection) ?