MARK3 and DYNLL1

Number of citations of the paper that reports this interaction (PMID 14760703)
24

Data Source:
HPRD (in vitro)

		MARK3	DYNLL1
Gene Name		MAP/microtubule affinity-regulating kinase 3	dynein, light chain, LC8-type 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Extracellular Vesicular Exosome	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane COP9 Signalosome Membrane Extracellular Vesicular Exosome Primary Cilium Mitotic Spindle Ciliary Tip
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Motor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Protein Homodimerization Activity
	Biological Process	Protein Phosphorylation	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transport Apoptotic Process Organelle Organization Microtubule-based Process Female Gamete Generation Anatomical Structure Morphogenesis Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Regulation Of Catalytic Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways			Organelle biogenesis and maintenance Activation of BH3-only proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Intraflagellar transport Loss of proteins required for interphase microtubule organizationÂ from the centrosome Activation of BIM and translocation to mitochondria Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Programmed Cell Death Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-Protein Interactions		27 interactors: ANKRD7 ASB13 ATP6V0C CDC25C CHGB CPSF4 DYNLL1 FANCF HDAC7 KSR1 MAP2 MAPT MITF NOL11 PIM1 PKP2 PMPCB PNPLA2 PRKCQ SAAL1 SFN TCEA2 TTR VPS11 YWHAG YWHAQ YWHAZ	77 interactors: ACTB ACTC1 ACTG1 ALDOA AMBRA1 AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C14orf1 CA2 CACNB1 CCDC36 CLIP2 CS DAZ1 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DYNC1H1 DYNC1I1 EEF1A1 GAPDH GLUD1 GLUL GNB2L1 GPHN GRIN3A HIP1R HSPA8 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MTA1 MTR MYO10 MYO5A NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 PAK1 PAN2 PARD3 PAX6 PFKM PFKP PKIA PKIB PKIG POLH RAB4A RGS2 SHROOM3 TERT THAP8 TNFRSF14 TP53BP1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A
Entrez ID		4140	8655
HPRD ID		04058	03334
Ensembl ID		ENSG00000075413	ENSG00000088986
Uniprot IDs		P27448 Q86U11	P63167 Q6FGH9
PDB IDs		2QNJ 3FE3	1CMI 3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Apoptotic Process Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Programmed Cell Death Cell Death Death Organelle Organization Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Apoptotic Process Positive Regulation Of Transport Regulation Of Cellular Component Organization Regulation Of Cell Death Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Apoptotic Process Multicellular Organismal Development Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death System Development Intracellular Signal Transduction Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Substantia Nigra Development Protein Targeting Regulation Of Protein Localization Developmental Process Cellular Response To Insulin Stimulus Neural Nucleus Development Signaling Anatomical Structure Development Regulation Of Phosphorylation Protein Targeting To Mitochondrion Regulation Of Cellular Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Intracellular Protein Transport Cell Communication Negative Regulation Of Apoptotic Process Positive Regulation Of T-helper 2 Cell Activation	Nervous System Development Movement Of Cell Or Subcellular Component Cell Differentiation Developmental Process Regulation Of Cellular Component Organization Response To Organic Substance Regulation Of Cellular Localization Neuron Projection Morphogenesis Axonogenesis Cellular Response To Stimulus Synapse Organization Neuron Projection Development Neuron Development Regulation Of Cellular Protein Metabolic Process Response To Stimulus Neuron Differentiation Regulation Of Protein Metabolic Process Axon Development Cell Projection Morphogenesis Response To External Stimulus Anatomical Structure Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Cellular Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Protein Homooligomerization Cell Morphogenesis Axon Guidance Negative Regulation Of Phosphorylation Regulation Of Cellular Process Glycolytic Process Locomotion Cell Development Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Membrane Organization Regulation Of CAMP-dependent Protein Kinase Activity Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Generation Of Neurons System Development Response To Stress Regulation Of Protein Phosphorylation Multicellular Organismal Development Neuromuscular Junction Development Pyruvate Metabolic Process Actin Filament-based Process
Tagcloud ?		acrylamide amiloride bbmv benzoyl border brush cariporide dihydro guanidine guanidino hnhe1 ic50 isopro isopropyl lap1 methane methylsulphonyl micromol nhe nhe1 nhe2 nhe3 ok opossum propenyl pylidene rbnhe2 s3226 sulphonate	1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Difference) ?		acrylamide amiloride bbmv benzoyl border brush cariporide dihydro guanidine guanidino hnhe1 ic50 isopro isopropyl lap1 methane methylsulphonyl micromol nhe nhe1 nhe2 nhe3 ok opossum propenyl pylidene rbnhe2 s3226 sulphonate	1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Intersection) ?