MARK3 and KSR1

Number of citations of the paper that reports this interaction (PubMedID 11741534)
0

Data Source:
HPRD (in vivo)

		MARK3	KSR1
Description		microtubule affinity regulating kinase 3	kinase suppressor of ras 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Cell Projection Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Ruffle Membrane Protein-containing Complex Cell Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Protein Phosphorylation Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus	MAPK Cascade Ras Protein Signal Transduction Regulation Of Cell Population Proliferation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Transcriptional and post-translational regulation of MITF-M expression and activity	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Fostamatinib
Diseases
GWAS		Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Cutaneous melanoma or hair colour ( 32341527) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Optic disc size ( 31809533) PR interval ( 32439900) Systolic blood pressure ( 30578418 30224653) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Systemic lupus erythematosus ( 28714469)
Interacting Genes		28 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CHGB CLASP1 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ SAAL1 SFN TCEA2 TTR VPS11 YWHAG YWHAZ	10 interacting genes: BRAP EPHB2 ITCH MAP2K1 MAPK1 MARK3 NME1 PJA2 RAF1 YWHAZ
Entrez ID		4140	8844
HPRD ID		04058	18980
Ensembl ID		ENSG00000075413	ENSG00000141068
Uniprot IDs		A0A7I2V2E3 A0A7I2V2N8 A0A7I2V3B9 A0A7I2V5G3 A0A7I2V639 A0A7I2YQF7 H0YNV4 P27448 Q86U11	A0A2R8Y5H9 Q8IVT5
PDB IDs		2QNJ 3FE3 7P1L 8UOH 8UOI 8UOJ 8UOK 8UOL	5VYK 7JUW 7JUX 7JUY 7JUZ 7JV0 7JV1 9AXH
Enriched GO Terms of Interacting Partners?		Protein Kinase C Inhibitor Activity Phosphoserine Residue Binding Main Axon Regulation Of Microtubule Polymerization Or Depolymerization Protein Sequestering Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Protein Kinase C Binding Regulation Of Phosphorylation Positive Regulation Of Intracellular Transport Dystroglycan Binding Protein Kinase Binding Tubulin Binding Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Phototransduction, Visible Light Regulation Of Cell Differentiation Microtubule	Transferase Activity Regulation Of MAPK Cascade ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway MAPK Cascade Schwann Cell Development Protein Modification Process Face Development ERBB2 Signaling Pathway Kinase Activity Thyroid Gland Development Protein Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Golgi Inheritance Negative Regulation Of Signal Transduction Thymus Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication ERK1 And ERK2 Cascade Regulation Of Cell Communication Regulation Of Signaling Protein Kinase Activity Glial Cell Development Trachea Formation ERBB Signaling Pathway Intracellular Signal Transduction Gland Development Bergmann Glial Cell Differentiation Myelination Axon Ensheathment Hematopoietic Or Lymphoid Organ Development Protein Metabolic Process Early Endosome Protein Serine Kinase Activity Negative Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Golgi Organization Pseudopodium ATP Binding Regulation Of Early Endosome To Late Endosome Transport Type B Pancreatic Cell Proliferation Regulation Of Defense Response Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Animal Organ Formation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Macromolecule Metabolic Process
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