MARK3 and FANCF

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		MARK3	FANCF
Description		microtubule affinity regulating kinase 3	FA complementation group F
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Cell Projection Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Protein Phosphorylation Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus	DNA Repair DNA Damage Response Interstrand Cross-link Repair
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Transcriptional and post-translational regulation of MITF-M expression and activity	Fanconi Anemia Pathway PKR-mediated signaling
Drugs		Fostamatinib
Diseases			Fanconi anemia
GWAS		Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Cutaneous melanoma or hair colour ( 32341527) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Optic disc size ( 31809533) PR interval ( 32439900) Systolic blood pressure ( 30578418 30224653) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)	Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465)
Interacting Genes		28 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CHGB CLASP1 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ SAAL1 SFN TCEA2 TTR VPS11 YWHAG YWHAZ	13 interacting genes: CTBP1 FAAP100 FAAP20 FANCA FANCB FANCC FANCE FANCG FANCL HES1 MARK3 OLFM2 TCP11
Entrez ID		4140	2188
HPRD ID		04058	04589
Ensembl ID		ENSG00000075413	ENSG00000183161
Uniprot IDs		A0A7I2V2E3 A0A7I2V2N8 A0A7I2V3B9 A0A7I2V5G3 A0A7I2V639 A0A7I2YQF7 H0YNV4 P27448 Q86U11	A3KME0 Q9NPI8
PDB IDs		2QNJ 3FE3 7P1L 8UOH 8UOI 8UOJ 8UOK 8UOL	2IQC 7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
Enriched GO Terms of Interacting Partners?		Protein Kinase C Inhibitor Activity Phosphoserine Residue Binding Main Axon Regulation Of Microtubule Polymerization Or Depolymerization Protein Sequestering Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Protein Kinase C Binding Regulation Of Phosphorylation Positive Regulation Of Intracellular Transport Dystroglycan Binding Protein Kinase Binding Tubulin Binding Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Phototransduction, Visible Light Regulation Of Cell Differentiation Microtubule	Fanconi Anaemia Nuclear Complex Interstrand Cross-link Repair DNA Repair Chromatin DNA Metabolic Process DNA Damage Response Cellular Response To Stress Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription Corepressor Binding Ovarian Follicle Development Negative Regulation Of Pancreatic A Cell Differentiation N-box Binding Negative Regulation Of Cell Fate Determination Positive Regulation Of Mitotic Cell Cycle, Embryonic Trochlear Nerve Development Macromolecule Metabolic Process Response To Stress Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Oculomotor Nerve Development Cajal-Retzius Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation Hindbrain Morphogenesis Renal Interstitial Fibroblast Development Nucleus Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Ureteric Bud Morphogenesis Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Amacrine Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Regulation Of Mitotic Cell Cycle, Embryonic HLH Domain Binding Metanephric Nephron Tubule Morphogenesis Midbrain-hindbrain Boundary Morphogenesis Stomach Neuroendocrine Cell Differentiation Response To Aroclor 1254 Regulation Of Forebrain Neuron Differentiation Ascending Aorta Morphogenesis Lateral Inhibition Comma-shaped Body Morphogenesis T Cell Antigen Processing And Presentation Regulation Of Sperm Capacitation Notch Signaling Pathway
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